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排序方式: 共有407条查询结果,搜索用时 46 毫秒
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Annamaria Mascolo Pasquale Maria Berrino Pietro Gareri Alberto Castagna Annalisa Capuano Ciro Manzo Liberato Berrino 《Inflammopharmacology》2018,26(5):1141-1149
Little is known about the development of psychosis during hydroxychloroquine (HCQ) treatment, especially in elderly patients affected by rheumatic diseases, with multiple comorbidities and treatments. To summarize the available evidence on HCQ-induced psychosis in elders, we performed a literature review. Additionally, individual case safety reports sent to the European Pharmacovigilance database (EudraVigilance) with HCQ as suspected drug and related to adverse events belonging to the System Organ Class ‘Psychiatric disorders’ were shown. Over the years, evidence was published about the risk of neuropsychiatric clinical manifestations during HCQ treatment for rheumatic diseases, but few of them were related to elderly patients. These adverse events can include less severe clinical manifestations such as affect lability and nervousness or more severe conditions such as actual psychosis and suicidal tendencies, which frequency are actually unknown. The presence of risk factors in these patients may precipitate HCQ-induced psychosis and their precocious detection could be associated with a risk minimization. Among predisposing risk factors, there are the co-exposure to interacting drugs, alcohol intake, familial history of psychiatric diseases, female gender, and the concomitant use of low-dose glucocorticoids. In some cases it was possible to reverse psychotic behaviour with the antipsychotic treatment or with HCQ suspension. 相似文献
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Mily Constanza Moreno Ramos Ligyana Korki de Candido Taine Costa Anna Caroline Leite Bruna Figueiredo Manzo Elysângela Dittz Duarte Denise Harrison Mariana Bueno 《Journal of neonatal nursing : JNN》2019,25(1):26-31
Objective
To identify the type and frequency of stressful and painful procedures, the use of pharmacological and non-pharmacological strategies; to identify relationships between demographic and clinical variables with frequency of procedures and pain management.Design
A prospective longitudinal study was conducted in neonatal intensive care units (NICU) of two hospitals in the city of Belo Horizonte, Brazil. 140 newborns admitted to the NICU between June 2014 and January 2015 were included.Results
A total of 21,291 procedures were documented, 18,131 (85.2%) stressful procedures and 3,160 (14.8%) invasive skin-breaking painful procedures. Each day of hospitalization increased by 10.9 the number of stressful procedures and by 2.2 the number of painful procedures. Furthermore, for each day of hospitalization, non-pharmacological strategies registered increased by 3.4% and pharmacological strategies, increased by 9.3%.Conclusion
Neonates underwent a high number of stressful and painful procedures and with infrequent use of pharmacological and non-pharmacological strategies during the entire hospitalization. 相似文献5.
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Lombardo F Salzano G Crisafulli G Valenzise M Zirilli G Manzo V Aversa T De Luca F 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2009,19(1):35-38
Background and aimPrevious studies on menarcheal age (MA) in type 1 diabetes mellitus (T1DM) have shown conflicting results about the effects of DM, but most lack a control group. The present study design is peculiar in that it covers a study population of 73 intensively treated menarcheal adolescents with premenarcheal onset of T1DM (Group A), whose MA was compared with that recorded in three control populations: the first one consisting of 280 healthy adolescents, the second one consisting of 20 T1DM adolescents with postmenarcheal DM onset (Group B) and the third one represented by the respective mothers.Methods and resultsMA of Group A patients was significantly delayed when compared with the respective mothers, healthy controls and Group B patients. By contrast MA of Group B girls was superimposable to the one of both their respective mothers and healthy controls. In Group A MA was strongly related (p < 0.0005) to HbA1c at the time of menarche and to average HbA1c concentrations during the last years before menarche. In Group A no relationship between patients' and mothers' MAs was found, whilst such a correlation was significant in Group B.Conclusions(a) MA is significantly delayed in girls with premenarcheal presentation of T1DM, even if intensively treated; (b) menarcheal retardation is more severe in the patients with suboptimal metabolic control at the time of menarche; and (c) MA in premenarcheal presenting T1DM is irrespective of maternal MA, age and HbA1c concentrations at DM presentation, body mass index and daily insulin dose at menarche. 相似文献
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Bugatti S Manzo A Bombardieri M Vitolo B Humby F Kelly S Montecucco C Pitzalis C 《Current rheumatology reports》2011,13(5):440-448
Rheumatoid arthritis is characterized by multiple pathobiological processes and heterogeneous clinical phenotypes. Not surprisingly,
the inflamed synovium harbors an equally complex pathology. This includes variability in infiltrating and resident cell populations,
spatial arrangements, and cell–cell interactions, as well as gene expression profiles. Remarkable progress in our understanding
of the many facets of tissue heterogeneity has been facilitated by the increasing availability of patients’ material and the
development of advanced research technologies. The next challenge is to capitalize on the large amount of data generated to
elucidate the specific pathogenic pathways disparately activated in different patients and/or different phases of the disease.
When tissue pathology can be reliably explored through noninvasive circulating biomarkers, then the circle will be closed.
We attempt to highlight key advances in the understanding of synovial tissue heterogeneity in rheumatoid arthritis and summarize
novel perspectives in synovial biomarker discovery in relation to peripheral blood. 相似文献
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Ingegnoli F Manzo A Fantini F Caporali R Montecucco C Pipitone N Pitzalis C 《Reumatismo》2002,54(1):12-18
Chemokines play a central role in the pathogenesis of rheumatoid arthritis (RA) synovitis which is characterised by new blood vessel formation, thickening of the lining layer and infiltration of immune cells. The inflammatory infiltrate is generated by a series of events which include the recruitment of leukocytes from the blood stream into the tissue, their local retention and activation to effector cells. All these processes are finely regulated by the interplay of different cell adhesion molecules (CAMs) and chemoattractant factors called chemokines (CK). CK are a superfamily of small proteins that play a crucial role in immune and inflammatory reactions. These chemoattractant cytokines share structural similarities including four conserved cysteine residues which form disulphide bonds in the tertiary structure of the proteins. CK mediate their effects by binding specific receptors (CK-R) characterised by a domain structure which spans the cell membrane seven times and signal through heterotrimeric GPT-binding proteins. Activation of the CK network results in an amplification of the inflammatory cascade and consequently in the progressive destruction of RA joints. The recognition of the central role of CK in inflammation has paved the way to the development of new agents capable of interfering with CK and CK-R. This review will focus in particular on the role of CK in regulating leukocyte trafficking in RA joints. 相似文献
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