全文获取类型
收费全文 | 2695篇 |
免费 | 196篇 |
国内免费 | 6篇 |
学科分类
医药卫生 | 2897篇 |
出版年
2023年 | 23篇 |
2022年 | 17篇 |
2021年 | 73篇 |
2020年 | 70篇 |
2019年 | 86篇 |
2018年 | 98篇 |
2017年 | 72篇 |
2016年 | 75篇 |
2015年 | 91篇 |
2014年 | 132篇 |
2013年 | 151篇 |
2012年 | 232篇 |
2011年 | 228篇 |
2010年 | 126篇 |
2009年 | 98篇 |
2008年 | 224篇 |
2007年 | 235篇 |
2006年 | 183篇 |
2005年 | 170篇 |
2004年 | 140篇 |
2003年 | 125篇 |
2002年 | 115篇 |
2001年 | 12篇 |
2000年 | 2篇 |
1999年 | 21篇 |
1998年 | 14篇 |
1997年 | 13篇 |
1996年 | 25篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 7篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1979年 | 1篇 |
1975年 | 1篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1970年 | 1篇 |
排序方式: 共有2897条查询结果,搜索用时 15 毫秒
1.
Leonie Konczalla Daniel R. Perez Nadine Wenzel Gerrit Wolters-Eisfeld Clarissa Klemp Johanna Lüddeke Annika Wolski Dirk Landschulze Chris Meier Anika Buchholz Dichao Yao Bianca T. Hofmann Julia K. Graß Sarah L. Spriestersbach Katharina Grupp Udo Schumacher Christian Betzel Svetlana Kapis Theresa Nuguid Pablo Steinberg Klaus Püschel Guido Sauter Maximillian Bockhorn Faik G. Uzunoglu Jakob R. Izbicki Cenap Güngör Alexander T. El Gammal 《International journal of cancer. Journal international du cancer》2020,146(6):1618-1630
MALT1 is a key mediator of NF-κB signaling and a main driver of B-cell lymphomas. Remarkably, MALT1 is expressed in the majority of pancreatic ductal adenocarcinomas (PDACs) as well, but absent from normal exocrine pancreatic tissue. Following, MALT1 shows off to be a specific target in cancer cells of PDAC without affecting regular pancreatic cells. Therefore, we studied the impact of pharmacological MALT1 inhibition in pancreatic cancer and showed promising effects on tumor progression. Mepazine (Mep), a phenothiazine derivative, is a known potent MALT1 inhibitor. Newly, we described that biperiden (Bip) is a potent MALT1 inhibitor with even less pharmacological side effects. Thus, Bip is a promising drug leading to reduced proliferation and increased apoptosis in PDAC cells in vitro and in vivo. By compromising MALT1 activity, nuclear translocation of c-Rel is prevented. c-Rel is critical for NF-κB-dependent inhibition of apoptosis. Hence, off-label use of Bip or Mep represents a promising new therapeutic approach to PDAC treatment. Regularly, the Anticholinergicum Bip is used to treat neurological side effects of Phenothiazines, like extrapyramidal symptoms. 相似文献
2.
3.
4.
Elena V. Preobrazhenskaya Aglaya G. Iyevleva Amina M. Suleymanova Vladislav I. Tiurin Natalia V. Mitiushkina Ilya V. Bizin Alexandr O. Ivanstov Olga A. Gorustovich Kseniya V. Shelekhova Denis Y. Kachanov Svetlana R. Varfolomeeva Vitaliy Y. Roschin Anna N. Kazakova Dmitriy V. Litvinov Tatiana V. Shamanskaya Nikita A. Savelov Evgeny N. Suspitsin Evgeny N. Imyanitov 《Pediatric blood & cancer》2020,67(5)
5.
6.
Arutiunian Vardan Lopukhina Anastasiya Minnigulova Alina Shlyakhova Anastasia Davydova Elizaveta Pereverzeva Darya Sorokin Alexander Tyushkevich Svetlana Mamokhina Uliana Danilina Kamilla Dragoy Olga 《Journal of autism and developmental disorders》2022,52(2):584-599
Journal of Autism and Developmental Disorders - The purpose of the present research was to comprehensively assess the language abilities of Russian primary-school-aged children with Autism Spectrum... 相似文献
7.
Artemov Sergey A. Belyaev Alexander N. Bushukina Olga S. Khrushchalina Svetlana A. Kostin Sergey V. Lyapin Andrey A. Ryabochkina Polina A. Taratynova Alina D. 《Lasers in medical science》2020,35(4):867-875
Lasers in Medical Science - Finding optimal parameters of endovenous laser coagulation using the radiation with a wavelength of 1910 nm. In vivo experiments have been carried out on the... 相似文献
8.
9.
Ayesha Baig Svetlana L. Avlasevich Dorothea K. Torous Jeffrey C. Bemis Lawrence J. Saubermann David P. Lovell James T. MacGregor Stephen D. Dertinger 《Environmental and molecular mutagenesis》2020,61(9):901-909
The etiology of distal site cancers in inflammatory bowel disease (IBD) is not well understood and requires further study. We investigated whether pediatric IBD patients' blood cells exhibit elevated levels of genomic damage by measuring the frequency of mutant phenotype (CD59-/CD55-) reticulocytes (MUT RET) as a reporter of PIG-A mutation, and the frequency of micronucleated reticulocytes (MN-RET) as an indicator of chromosomal damage. IBD patients (n = 18 new-onset disease, 46 established disease) were compared to age-matched controls (constipation or irritable bowel syndrome patients from the same clinic, n = 30) and young healthy adults age 19–24 (n = 25). IBD patients showed no indication of elevated MUT RET relative to controls (mean ± SD = 3.1 ± 2.3 × 10−6 vs. 3.6 ± 5.6 x 10−6, respectively). In contrast, 59 IBD patients where %MN-RET measurements were obtained, 10 exceeded the upper bound 90% tolerance interval derived from control subjects (i.e., 0.42%). Furthermore, each of the 10 IBD patients with elevated MN-RET had established disease (10/42), none were new-onset (0/17) (p = .049). Interestingly, each of the subjects with increased chromosomal damage was receiving anti-TNF based monotherapy at the time blood was collected (10/10, 100%), whereas this therapy was less common (20/32, 63%) among patients that exhibited ≤0.42% MN-RET (p = .040). The results clearly indicate the need for further work to understand whether the results presented herein are reproducible and if so, to elucidate the causative factor(s) responsible for elevated MN-RET frequencies in some IBD patients. 相似文献
10.
Dorothea K. Torous Svetlana L. Avlasevich Mona G. Khattab Ayesha Baig Lawrence J. Saubermann Yuhchyau Chen Jeffrey C. Bemis David P. Lovell Vernon E. Walker James T. MacGregor Stephen D. Dertinger 《Environmental and molecular mutagenesis》2020,61(8):807-819
We previously described flow cytometry-based methods for scoring the incidence of micronucleated reticulocytes (MN-RET) and PIG-A mutant phenotype reticulocytes (MUT RET) in rodent and human blood samples. The current report describes important methodological improvements for human blood analyses, including immunomagnetic enrichment of CD71-positive reticulocytes prior to MN-RET scoring, and procedures for storing frozen blood for later PIG-A analysis. Technical replicate variability in MN-RET and MUT RET frequencies based on blood specimens from 14 subjects, intra-subject variability based on serial blood draws from 6 subjects, and inter-subject variation based on up to 344 subjects age 0 to 73 years were quantified. Inter-subject variation explained most of the variability observed for both endpoints (≥77%), with much lower intra-subject and technical replicate variability. The relatively large degree of inter-subject variation is apparent from mean and standard deviation values for MN-RET (0.15 ± 0.10%) and MUT RET (4.7 ± 5.0 per million, after omission of two extreme outliers). The influences of age and sex on inter-subject variation were investigated, and neither factor affected MN-RET whereas both influenced MUT RET frequency. The lowest MUT RET values were observed for subjects <11 years old, and males had moderately higher frequencies than females. These results indicate that MN-RET and MUT RET are automation-compatible biomarkers of genotoxicity that bridge species of toxicological interest to include human populations. These data will be useful for appropriately designing future human studies that include these biomarkers of genotoxicity, and highlight the need for additional work aimed at identifying the sources of inter-individual variability reported herein. 相似文献