颞下颌关节骨关节炎与关节内紊乱关系的研究

目的 :探讨颞颌关节骨关节炎 (TMJOA)与颞颌关节内紊乱 (TMJID)的关系。方法 :利用MRI金标准 ,对 44例颞颌关节紊乱病患者 88侧关节完成开闭口T1加权成像 ,观察盘突关系和骨改变。结果 :88个关节中40 .9% ( 3 6/88)表现为TMJID ,13 .6% ( 12 /88)表现为TMJOA ,骨改变的分布情况 :正常盘突关系 (NDCR)关节中 2个 ,破坏和骨赘各 1个 ;可复性关节盘前移位 (ADDR)关节中 3个全部表现为骨破坏 ;不可复性关节盘前移位 (AD DWR)关节中 7个 ,表现为髁状突变平 3个 ;表现为破坏、骨赘、硬化和短小各 1个 ,统计学分析发现TMJOA与TMJID具有显著相关性。结论 :TMJOA的发生与关节结构紊乱显著相关。由于TMJOA可独立于TMJID之外而单独存在 ,目前将TMJOA看作是与TMJID密切相关的另一类疾病较为合适。     

氙光低周波加封闭治疗腰腿痛的临床观察

我们对门诊就诊５２例腰腿痛病人，男３０人，女２２人，随机分为三组进行了对比观察。患者分组１（超短波组）、组２（Ｘｅｎｏｎ氙光低周波治疗组）和组３（氙光低周波加椎旁或硬膜外腔封闭组）。对于上述各组以ＶｉｓｕａｌＡｎａｌｏｇＳｃａｌｅ（ＶＡＳ）测痛法以疼痛为主要指标、快适度以舒适轻松程度为主要指标，就治疗前后自觉症状的改变进行了评价及统计学处理。结果表明：组３优于组２，组２优于组１，都具有显著性差异。本组结果提示日本医广公司生产的５５０／型氙光低周波治疗仪加激素类药物行椎旁或硬膜外腔封闭具有良好的协同作用，治疗效果显著。使ＶＡＳ痛苦度明显降低，同时治疗后还具有良好的舒适感，是治疗腰腿痛的好方法。     

British Society for Immunology/United Kingdom Primary Immunodeficiency Network consensus statement on managing non-infectious complications of common variable immunodeficiency disorders

Common variable immunodeficiency (CVID) represents a heterogeneous group of rare disorders. There is considerable morbidity and mortality as a result of non-infectious complications, and this presents clinicians with management challenges. Clinical guidelines to support the management of CVID are urgently required. The UK Primary Immunodeficiency Network and the British Society for Immunology funded a joint project to address this. A modified Delphi Survey was conducted for the assessment, diagnosis and treatment of the non-infectious blood, respiratory, gut and liver complications of CVID. A steering group of 10 consultant immunologists and one nurse specialist developed and reviewed the survey statements and agreed the final recommendations. In total, 22 recommendations and three areas for research were developed.     

硒和维生素E对大鼠心肌单胺类物质和单胺氧化酶的影响

本文观察了硒（Ｓｅ）和维生素Ｅ（ＶＥ）对大鼠心肌去甲肾上腺素（ＮＥ）、多巴胺（ＤＡ）、５羟色胺（５－ＨＴ）含量和单胺氧化酶Ａ（ＭＡＯ－Ａ）、单胺氧化酶Ｂ（ＭＡＯ－Ｂ）活性的影响，发现经低Ｓｅ、低ＶＥ饲料喂养１０周，并且处死前经２次冰浴刺激的大鼠心肌ＮＥ含量明显增高，ＭＡＯ－Ａ活性降低，ＭＡＯ－Ｂ活性增加，通过补充饲料中Ｓｅ和ＶＥ，对上述指标有不同程度的改善，并以联合补充Ｓｅ和ＶＥ效果最佳。本研究结     

过量氟化物对软骨基质糖胺多糖,蛋白多糖代谢的影响

在偏食和过量氟喂养条件下，实验大鼠软骨组织ＰＧ、ＧＡＧ代谢受到严重干扰，表现为肋软骨基质中ＰＧ聚合体含量明显降低，低聚合的ＰＧ含量明显增加，ＰＧ单体分子量明显降低。同时观察到软骨基南中ＧＡＧ含量的明显升高，这些结果一致地表明，过量氟化物引起动物慢性中毒辣时软骨组织ＰＧ合成代谢受到抑制而其分解代谢增强     

Development of a high-performance liquid chromatographic assay for G418 sulfate (Geneticin).

We have developed a chromatographic assay with high sensitivity and specificity to quantify G418 sulfate (Geneticin), an antibiotic used routinely in molecular genetics experiments for selecting eukaryotic transformants. With this method, G418 in tissues and plasma samples can be quantitated without the confounding factors often associated with biological assays. After removal of proteins in homogenized tissue or plasma samples with methanol (2:1, vol/vol), the amino group of G418 was derivatized with 1-fluoro-2,4-dinitrobenzene (DNFB) to form the UV-visible G418-DNFB product. The DNFB-derivatized G418 was separated on a reversed-phase C18 column with an acetonitrile and water gradient as the mobile phase. Under these assay conditions, the detection limit for G418 sulfate in buffer, plasma, and tissues was recorded at 78 ng/ml and the linearity was recorded for concentrations up to 100 micrograms/ml. The data obtained from this analysis indicate that this assay can be used for the quantitative determination of G418 sulfate in plasma and tissue samples.     

关于设立医疗损害赔付基金的建议和思考

依据医学界在治疗疾病过程中医源性疾病和医源性损害不可能完全避免性，为保证医疗消费公平、公正，防止医疗纠纷不断升级的势头，提出“设立医疗损害赔付基金”的建议。医疗损害赔付基金的来源应由医务人员、医疗机构及医药产品的生产、销售企业共同承担，基金的赔付应实行有限补偿、部分损害陪付、特殊病种拒付及损害和责任分享等原则。文章同时就赔付程序及有关细节问题提出相关建议。