全文获取类型
收费全文 | 18477篇 |
免费 | 1281篇 |
国内免费 | 72篇 |
学科分类
医药卫生 | 19830篇 |
出版年
2023年 | 200篇 |
2022年 | 196篇 |
2021年 | 727篇 |
2020年 | 505篇 |
2019年 | 641篇 |
2018年 | 721篇 |
2017年 | 495篇 |
2016年 | 559篇 |
2015年 | 629篇 |
2014年 | 842篇 |
2013年 | 1050篇 |
2012年 | 1494篇 |
2011年 | 1627篇 |
2010年 | 843篇 |
2009年 | 681篇 |
2008年 | 1164篇 |
2007年 | 1166篇 |
2006年 | 961篇 |
2005年 | 934篇 |
2004年 | 759篇 |
2003年 | 725篇 |
2002年 | 630篇 |
2001年 | 202篇 |
2000年 | 173篇 |
1999年 | 153篇 |
1998年 | 93篇 |
1997年 | 87篇 |
1996年 | 77篇 |
1995年 | 67篇 |
1994年 | 54篇 |
1993年 | 58篇 |
1992年 | 74篇 |
1991年 | 96篇 |
1990年 | 76篇 |
1989年 | 64篇 |
1988年 | 59篇 |
1987年 | 65篇 |
1986年 | 60篇 |
1985年 | 64篇 |
1984年 | 62篇 |
1983年 | 65篇 |
1982年 | 52篇 |
1981年 | 48篇 |
1980年 | 55篇 |
1979年 | 30篇 |
1978年 | 27篇 |
1977年 | 27篇 |
1975年 | 24篇 |
1973年 | 29篇 |
1970年 | 24篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Nicla La Verde Agostino Riva Maria Silvia Cona Arianna Gabrieli Monica Cattaneo Cinzia Fasola Giuseppe Lipari Claudia De Stradis Valentina Favorito Benedetta Lombardi Stocchetti Davide Chizzoniti Alice Covizzi Eliana Rulli Francesca Galli Lorenzo Ruggieri Anna Gambaro Sabrina Ferrario Davide Dalu Maciej S. Tarkowski 《International journal of cancer. Journal international du cancer》2023,152(4):661-671
Previous studies on the immunogenicity of SARS-CoV-2 mRNA vaccines showed a reduced seroconversion in cancer patients. The aim of our study is to evaluate the immunogenicity of two doses of mRNA vaccines in solid cancer patients with or without a previous exposure to the virus. This is a single-institution, prospective, nonrandomized study. Patients in active treatment and a control cohort of healthy people received two doses of BNT162b2 (Comirnaty, BioNTech/Pfizer, The United States) or mRNA-1273 (Spikevax, Moderna). Vaccine was administered before starting anticancer therapy or on the first day of the treatment cycle. SARS-CoV-2 antibody levels against S1, RBD (to evaluate vaccine response) and N proteins (to evaluate previous infection) were measured in plasma before the first dose and 30 days after the second one. From January to June 2021, 195 consecutive cancer patients and 20 healthy controls were enrolled. Thirty-one cancer patients had a previous exposure to SARS-CoV-2. Cancer patients previously exposed to the virus had significantly higher median levels of anti-S1 and anti-RBD IgG, compared to healthy controls (P = .0349) and to cancer patients without a previous infection (P < .001). Vaccine type (anti-S1: P < .0001; anti-RBD: P = .0045), comorbidities (anti-S1: P = .0274; anti-RBD: P = .0048) and the use of G-CSF (anti-S1: P = .0151) negatively affected the antibody response. Conversely, previous exposure to SARS-CoV-2 significantly enhanced the response to vaccination (anti-S1: P < .0001; anti-RBD: P = .0026). Vaccine immunogenicity in cancer patients with a previous exposure to SARS-CoV-2 seems comparable to that of healthy subjects. On the other hand, clinical variables of immune frailty negatively affect humoral immune response to vaccination. 相似文献
2.
Tiago Ribeiro Leal Larissa Chaves Morais de Lima rick Tssio Barbosa Neves Maria Jacinta Arêa Leo Lopes Araújo Arruda Matheus Frana Perazzo Saul Martins Paiva Júnia Maria Serra-Negra Fernanda de Morais Ferreira Ana Flvia Granville-Garcia 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2022,32(1):22-30
3.
4.
Penelas Alice Gonçalves da Silva Eduardo Moreira Fedozzi Julia Mattos Alves Amanda Cypriano Orem Paulo Roberto Barros Poskus Laiza Tatiana Feitosa Victor Pinheiro Guimarães José Guilherme Antunes 《Odontology / the Society of the Nippon Dental University》2022,110(3):569-576
Odontology - This study aimed at evaluating the influence of glass-fiber post (GFP) relining with composites of different opacities on resin cement layer thickness (CLT), bond strength (BS) to root... 相似文献
5.
Yu-Tzu Chan Alan C.-Y. Lai Ruey-Jen Lin Ya-Hui Wang Yi-Ting Wang Wen-Wei Chang Hsin-Yi Wu Yu-Ju Lin Wen-Ying Chang Jen-Chine Wu Jyh-Cherng Yu Yu-Ju Chen Alice L. Yu 《International journal of cancer. Journal international du cancer》2020,146(6):1674-1685
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non-BCSCs of three patient-derived xenografts of ER−/PR+ breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations. Comparative phosphoproteomics revealed greater GPER-mediated PKA/BAD signaling in BCSCs. Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics. Transfection with a dominant-negative mutant BAD (Ser118Ala) led to reduced cell survival. Taken together, GPER and its downstream signaling play a key role in maintaining the stemness of BCSCs, suggesting that GPER is a potential therapeutic target for eradicating BCSCs. 相似文献
6.
Recent years have seen tremendous advances in treating acute myeloid leukemia (AML), largely because of progress in understanding the genetic basis of the disease. The US Food and Drug Administration approved 7 agents for AML in the last 2 years: the first new drugs in decades. In this review, the authors discuss these new approvals in the backdrop of an overall strategy for treating AML today. Treating AML in the modern era requires: 1) access to and use of upfront genetic and cytogenetic testing, not only to describe prognosis but also to help identify the best available therapy; 2) effectively working new therapies into a conventional backbone of treatment, including transplantation; and 3) continued commitment to clinical trials designed to capitalize on advances in genetics and immunology to foster the next wave of drug approvals. 相似文献
7.
de Morais Pollyana C. V. Gama Allyne F. Fernandes Gabrielle M. Oliveira Andre H. B. Lima Marcielly F. B. dos Santos Felipe R. Martins Davi A. Nascimento Ronaldo F. Cavalcante Rivelino M. 《Bulletin of environmental contamination and toxicology》2019,102(1):66-76
Bulletin of Environmental Contamination and Toxicology - This work describes the development of an analytical protocol combining cleanup by liquid–solid extraction and GC–MS for the... 相似文献
8.
9.
10.
Alice Carvalhais Joana Araújo Renato Natal Jorge Kari Bø 《Journal of Science and Medicine in Sport》2019,22(2):140-144