全文获取类型
收费全文 | 1872篇 |
免费 | 98篇 |
国内免费 | 5篇 |
学科分类
工业技术 | 1975篇 |
出版年
2023年 | 10篇 |
2022年 | 7篇 |
2021年 | 26篇 |
2020年 | 33篇 |
2019年 | 39篇 |
2018年 | 60篇 |
2017年 | 43篇 |
2016年 | 49篇 |
2015年 | 45篇 |
2014年 | 69篇 |
2013年 | 113篇 |
2012年 | 118篇 |
2011年 | 132篇 |
2010年 | 112篇 |
2009年 | 117篇 |
2008年 | 107篇 |
2007年 | 88篇 |
2006年 | 86篇 |
2005年 | 59篇 |
2004年 | 63篇 |
2003年 | 45篇 |
2002年 | 47篇 |
2001年 | 34篇 |
2000年 | 24篇 |
1999年 | 39篇 |
1998年 | 84篇 |
1997年 | 70篇 |
1996年 | 46篇 |
1995年 | 46篇 |
1994年 | 26篇 |
1993年 | 26篇 |
1992年 | 11篇 |
1991年 | 12篇 |
1990年 | 5篇 |
1989年 | 14篇 |
1988年 | 8篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 7篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1976年 | 7篇 |
1973年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有1975条查询结果,搜索用时 281 毫秒
1.
Juliano Henrique Borges Daniel Minutti de Oliveira Sofia Helena Valente de Lemos-Marini Bruno Geloneze Ezequiel Moreira Gonçalves Gil Guerra-Júnior 《Lipids》2021,56(1):101-110
We aimed to compare detailed fat distribution and lipid profile between young adults with congenital adrenal hyperplasia due to 21-hydroxylase enzyme deficiency and a control group. We also verified independent associations of treatment duration and daily hydrocortisone dose equivalent (HDE) with lipid profile within patients. This case–control study included 23 patients (7 male and 16 female) matched by an age range of young adults (18–31 years) with 20 control subjects (8 male and 12 female). Dual energy X-ray absorptiometry was used to measure the fat distribution. Male patients demonstrated elevated indices of fat mass for total (7.7 ± 2.1 vs. 4.5 ± 1.3 kg/m2, p = 0.003), trunk (4.0 ± 1.2 vs. 2.2 ± 0.8 kg/m2, p = 0.005), android (0.63 ± 0.24 vs. 0.32 ± 0.15 kg/m2, p = 0.008), gynoid (1.34 ± 0.43 vs. 0.74 ± 0.24 kg/m2, p = 0.005), arm (0.65 ± 0.16 vs. 0.39 ± 0.10 kg/m2, p = 0.009), and leg regions (2.7 ± 0.8 vs. 1.6 ± 0.4 kg/m2, p = 0.005) than the control group, but not in females. However, female patients demonstrated elevated ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (1.90 ± 0.46 vs. 1.39 ± 0.47, p = 0.009) than the control group, but not in males. Total fat mass was inversely correlated with total testosterone (r = −0.64, p = 0.014) and positively correlated with leptin in males (r = 0.75, p = 0.002). An elevated daily HDE (β = 0.43, p = 0.038 and β = 0.47, p = 0.033) and trunk to total fat mass ratio (β = 0.46, p = 0.025, and β = 0.45, p = 0.037) were independently correlated with impaired lipid profile markers. Although there is no altered lipid profile, male patients demonstrated an increased fat distribution. However, female patients presented with an impaired lipid profile marker but demonstrated close values of normal fat distribution. Interestingly, the dose of glucocorticoid therapy can have some role in the lipid mechanisms. 相似文献
2.
3.
Maria Jos G. Fernandes Renato B. Pereira David M. Pereira A. Gil Fortes Elisabete M. S. Castanheira M. Sameiro T. Gonalves 《International journal of molecular sciences》2020,21(23)
Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a propyl chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were later subjected to epoxidation conditions to give the corresponding oxiranes. All derivatives were evaluated against their effect upon the viability of insect cell line Sf9 (Spodoptera frugiperda), demonstrating that structural changes elicit marked effects in terms of potency. In addition, the most promising molecules were evaluated for their impact in cell morphology, caspase-like activity, and potential toxicity towards human cells. Some molecules stood out in terms of toxicity towards insect cells, with morphological assessment of treated cells showing chromatin condensation and fragmentation, which are compatible with the occurrence of programmed cell death, later confirmed by evaluation of caspase-like activity. These findings point out the potential use of eugenol derivatives as semisynthetic insecticides from plant natural products. 相似文献
4.
A.B. Haugen A. Geffroy A. Kaiser V. Gil 《Journal of the European Ceramic Society》2018,38(9):3279-3285
The gas permeability of Y0.03Zr0.97O2 (3Y-TZP) porous supports from thermoplastic feedstocks has been improved by adding MgO as a non-pyrolyzable pore former. Common pyrolyzable pore formers such as graphite often produce tortuous and narrow pore channels with low gas permeability, limiting the performance of oxygen transport membranes or other membranes relying on gas transport to the active membrane surface. Thermoplastic feedstocks for extrusion of tubular 3Y-TZP supports were prepared with four different amounts of pyrolyzable pore formers and/or MgO as non-pyrolyzable pore former. The MgO was removed after sintering by leaching in acetic acid. With this technique we obtained porosities above 70 vol% and gas permeabilities above 3?10?14?m2. Compared to samples with only pyrolyzable pore formers, the non-pyrolyzable pore former increases the gas permeability and reduces the tortuosity. 相似文献
5.
Gil Costa Machado Esther García-Tuñón Robert V. Bell Mauro Alini Eduardo Saiz Marianna Peroglio 《Journal of the European Ceramic Society》2018,38(3):949-961
Calcium phosphates (CaP) have been the subject of several studies that often lack a systematic approach to understanding how their properties affect biological response. CaP particles functionalised with a pH-responsive polymer (BCS) were used to prepare microporous substrates (porosity between 70 and 75% and pore sizes of 5–20 μm) through the aggregation of oil-in-water emulsions by controlling solid loading, emulsification energy, pH, drying and sintering conditions. The combined effect of surface roughness (roughness amplitude, Ra between 0.9–1.7 μm) and chemistry (varying Hydroxyapatite/β-Tricalcium phosphate ratio) on human mesenchymal stem cells was evaluated. HA substrates stimulated higher cell adhesion and proliferation (especially with lower Ra), but cell area increased with β-TCP content. The effect of surface roughness depended of chemistry: HA promoted higher mineralising activity when Ra ~ 1.5 μm, whereas β-TCP substrates stimulated a more osteogenic profile when Ra ~ 1.7 μm. A novel templating method to fabricate microporous CaP substrates was developed, opening possibilities for bone substitutes with controlled features. 相似文献
6.
7.
8.
Shmuel Borenstain Gil Bar-Haim Keren Goldshtein Gili Cohen-Taguri 《Color research and application》2020,45(6):1153-1169
Investigation of ink formulation options with the purpose to obtain color-gamut-optimal set of Cyan Magenta and Yellow CMY inks is reported. Implementation of the thickness dependent Kubelka-Munk model on multiple ink layers having different and well-defined thicknesses, provides characteristic absorption and scattering (K, S ) spectra of the ink ingredients. These data enable accurate computation of the reflectance spectrum and thus the L*a*b* color coordinates for any given ink thickness or substrate. Pigment materials investigated are quinacridone as magenta, copper-phthalocyanine as cyan, and arylide yellow. Scaling the peak of the absorption band to the number of molecules per unit area for the specific pigments studied in this article provides the molar extinction coefficients, 1.21 × 104 , 4.7 × 104 , and 3.3 × 104 cm2/millimole respectively, regardless of the different ink formulations used, in accord with Avogadro's principle. Having a set of three pairs of K, S spectra is used to compute the color gamut of any CMY color combination in the L*a*b* space as a function of ink layer thickness and formulation. Using an iterative algorithm, a color-gamut-optimal set of CMY inks is obtained. 相似文献
9.
10.
Daniel Boon Loong Teh Akshaya Bansal Chou Chai Tan Boon Toh Robert Alan Jappy Tucker Gil Gerald Lasam Gammad Yanzhuang Yeo Zhendong Lei Xiang Zheng Fengyuan Yang John S. Ho Nagarjun Bolem Bing Cheng Wu Muthu Kumar Gnanasammandhan Lissa Hooi Gavin Stewart Dawe Camilo Libedinsky Wei-Yi Ong Barry Halliwell Edward Kai-Hua Chow Kah-Leong Lim Yong Zhang Brian K. Kennedy 《Advanced materials (Deerfield Beach, Fla.)》2020,32(29):2001459
Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA-approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5-aminolevulinic acid (5-ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR-based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep-tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep-tissue light delivery. 相似文献