用放射自显影术观察~(14)C脒基硫脲在动物体内的分布和代谢

本文介绍用整体、显微、层析放射自显影技术观察~(14)C-ASU在小白鼠体内吸收分布与排出,揭示~(14)C-ASU在小鼠体内半小时吸收达到高峰并全身分布。~(14)C-ASU化合物在体内仍以原来形式存在,不直接参与体内代谢作用,说明它在体内累积中毒的可能性小。     

THE METABOLISM OF TITANIUM AND OTHER ELEMENTS IN WISTER RATS

The concentrations of Ti and Ca, P, K, Fe, Cu and Zn in blood samples were determined by PIXE after a single intravenous and a single oral dosing with titanium- ascorbate (Ti- Vc) in Wister rats. Following the intravenous injection with 50 mg Ti- Vc/kg body weight, the absorption, distribution and clearance in blood could be described by an exponential equation of three terms. After gavaged with 500 mg Ti-Vc/kg body weight, at 1.5 h the content of Ti reached the highest level. The concentration of Ca was increasing, with the absorption, distribution and clearance of Ti in blood. The contents of Fe and K were decreasing. And the contents of Cu and Zn were significantly fluctuating. The effect of Ti on animal growth could be explained by the fact that Ti- Vc supplementation could promote the absorption of Ca.