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In order to explore this type of ~(99m)Tc-GH and N_2S_2 ligands exchange reaction as a common method for the preparation of ~(99m)Tc-N_2S_2 complexes, detailed kinetic study of ligand exchange reaction between ~(99m)Tc-GH and ECD was carried out. This paper presents preliminary results from the study at different ligand concentrations and pH values. The ligand exchange reaction is a second order reaction. Its rate constant being pH dependent were determined as: k_(pH2)=1.11×104 l.mol~(-1). min~(-1), k_(pH5)=1.34×10~4 l.mol~(-1) min~(-1), kpH6=2.24×10~4 l. mol~(-1).min~(-1). 相似文献
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研究显示了^99mTc-EC的化学量对小鼠肾放射量浓聚有很大的影响,只有当鼠接受1.25mg/kg剂量时肾的放射量最高,肾/肝达3.2。它的小鼠毒性和与血浆蛋白的结合率均低。14例健康志愿者肾显像表明^99mTc-EC是一种有用的锝标记肾功能显像剂。 相似文献