Sensitiveness of Porous Silicon‐Based Nano‐Energetic Films

Nanoporous silicon (pSi) films on a silicon wafer were loaded with sodium perchlorate and perfluoropolyether (PFPE) oxidizing agents. Sensitiveness to impact, friction and electrostatic discharge (ESD) of the resulting energetic thin films were investigated. It was observed that pSi loaded with perchlorate was sensitive at the lowest limit of detection for the available equipment (<4.9 J impact energy, <5 N friction force, and <45 mJ ESD spark energy). When loaded with PFPE the material was very sensitive to impact (<4.9 J), moderately sensitive to ESD (between 45 and 100 mJ) and insensitive to friction (>360 N). pSi loaded with either perchlorate or PFPE displayed behavior during sensitiveness testing similar to other primary explosive materials.     

Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery

The critical role of mitochondria in programmed cell death leads to the design of mitochondriotropic agents as a strategy in regulating apoptosis. For anticancer therapy, stimulation of proapoptotic mitochondrial events in tumor cells and their suppression in surrounding normal cells represents a promising paradigm for new therapies. Different approaches targeting regulation of components of mitochondrial antioxidant system such as Mn-SOD demonstrated significant antitumor efficiency, particularly in combination therapy. This review is focused on a newly discovered early stage of mitochondria-dependent apoptosis - oxidative lipid signaling involving a mitochondria-specific phospholipid cardiolipin (CL). Cytochrome c (cyt c) acts as a CL-specific peroxidase very early in apoptosis. At this stage, the hostile events are still secluded within the mitochondria and do not reach the cytosolic targets. CL oxidation process is required for the release of pro-apoptotic factors into the cytosol. Manipulation of cyt c interactions with CL, inhibition of peroxidase activity, and prevention of CL peroxidation are prime targets for the discovery of anti-apoptotic drugs acting before the "point-of-no-return" in the fulfillment of the cell death program. Therefore, mitochondria-targeted disruptors and inhibitors of cyt c/CL peroxidase complexes and suppression of CL peroxidation represent new strategies in anti-apoptotic drug discovery.     

Psychotherapy as a personal relationship: A social psychological perspective.

Shows how theory and research on personal relationships can increase understanding of the therapy relationship. The article focuses on a social exchange approach to satisfaction and commitment to therapy, responsiveness in the therapy relationship, and the development of the therapy relationship (gradual or accelerated). By examining how therapy is a professional relationship and how it is similar to other personal relationships, therapists and clients may be encouraged to acknowledge the personal elements in the therapy relationship. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Peroxidase-catalyzed oxidation of β-carotene in HL-60 cells and in model systems: Involvement of phenoxyl radicals

Recent studies provide extensive evidence for the importance of carotenoids in protecting against oxidative stress associated with a number of diseases. In particular, reactions of carotenoids with phenoxyl radicals generated by peroxidasecatalyzed one-electron metabolism of phenolic compounds may represent an important antioxidant function of carotenoids. To further our understanding of the antioxidant mechanisms of carotenoids, we used in the present work two different phenolic compounds, phenol and a polar homologue of vitamin E (2,2,5,7,8-pentamethyl-6-hydroxychromane, PMC), as representatives of two different types of phenols to study reactions of their respective phenoxyl radicals with carotenoids in cells and in model systems. We found that phenoxyl radicals of PMC did not oxidize β-carotene in either HL-60 cells or in model systems with horseradish peroxidase (HRP)/H₂O₂. In contrast, the phenoxyl radicals generated from phenol (by native myeloperoxidase in HL-60 cells or HRP/H₂O₂ in model systems) effectively oxidized β-carotene and other carotenoids (canthaxanthin, lutein, lycopene). One-electron reduction of the phenoxyl radical by ascorbate (assayed by electron spin resonance-detectable formation of semidehydroascorbyl radicals) prevented HRP/H₂O₂-induced oxidation of β-carotene. PMC, but not phenol, protected β-carotene against oxidation induced by a lipid-soluble azo-initiator of peroxyl radicals. No adducts of peroxidase/phenol/H₂O₂-induced β-carotene oxidation intermediates with phenol were detected by high-performance liquid chromatography-mass spectrometry analysis of the reaction mixture. Since carotenoids are essential constituents of the antioxidant defenses in cells and biological fluids, their depletion through the reaction with phenoxyl radicals formed from endogenous, nutritional and environmental phenolics, as well as phenolic drugs, may be an important factor in the development of oxidative stress.     

Synthesis of Metal-containing Polymers via Ring Opening Metathesis Polymerization (ROMP). Part I. Polymers Containing Main Group Metals

Synthesis of a broad range of diverse polymers containing main group metals by the new ROMP approach starting from metal-functionalized cyclic monomers and taking advantage of both classical and well-defined W-, Mo- and Ru-based metathesis catalytic systems is critically surveyed. Emphasis is laid upon Si-containing ring-opening metathesis polymers, popular due to the easy accessibility of the corresponding monomers and the valuable properties of the obtained polymers. Also highlighted is the production of modern advanced materials based on metal-containing polymers as well as some of their multifarious applications. Future opportunities for this field are finally outlined.     

Neuroticism and disclosure reciprocity.

49 male undergraduates identified as either "normal" or "neurotic" by their scores on the Maudsley Personality Inventory were exposed to a confederate who disclosed either intimate or superficial information about himself, as part of an "impression formation" study. Normal males reciprocated disclosure at a level of intimacy similar to the confederates, but neurotics disclosed at a moderate level regardless of whether the confederate's initial disclosure was intimate or superficial. Results suggest that neuroticism may be related to inappropriate or nonnormative disclosure, rather than characteristically high or low levels of disclosure. (26 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of bus size and operation to crash occurrences

This paper evaluates roadway and operational factors considered to influence crashes involving buses. Factors evaluated included those related to bus sizes and operation services. Negative binomial (NB) and multinomial logit (MNL) models were used in linearizing and quantifying these factors with respect to crash frequency and injury severities, respectively. The results showed that position of the bus travel lane, presence or absence of on-street shoulder parking, posted speed limit, lane width, median width, number of lanes per direction and number of vehicles per lane has a higher influence on bus crashes compared to other roadway and traffic factors. Wider lanes and medians were found to reduce probability of bus crashes while more lanes and higher volume per lane were found to increase the likelihood of occurrences of bus-related crashes. Roadways with higher posted speed limits excluding freeways were found to have high probability of crashes compared to low speed limit roadways. Buses traveling on the inner lanes and making left turns were found to have higher probability of crashes compared to those traveling on the right most lanes. The same factors were found to influence injury severity though with varying magnitudes compared to crash frequency.     

Biodegradation of Single‐Walled Carbon Nanotubes by Eosinophil Peroxidase

Eosinophil peroxidase (EPO) is one of the major oxidant‐producing enzymes during inflammatory states in the human lung. The degradation of single‐walled carbon nanotubes (SWCNTs) upon incubation with human EPO and H₂O₂ is reported. Biodegradation of SWCNTs is higher in the presence of NaBr, but neither EPO alone nor H₂O₂ alone caused the degradation of nanotubes. Molecular modeling reveals two binding sites for SWCNTs on EPO, one located at the proximal side (same side as the catalytic site) and the other on the distal side of EPO. The oxidized groups on SWCNTs in both cases are stabilized by electrostatic interactions with positively charged residues. Biodegradation of SWCNTs can also be executed in an ex vivo culture system using primary murine eosinophils stimulated to undergo degranulation. Biodegradation is proven by a range of methods including transmission electron microscopy, UV‐visible‐NIR spectroscopy, Raman spectroscopy, and confocal Raman imaging. Thus, human EPO (in vitro) and ex vivo activated eosinophils mediate biodegradation of SWCNTs: an observation that is relevant to pulmonary responses to these materials.     

2D Eddy current sensor array

This paper presents the design and development of a two-dimensional eddy current sensor array and the improved response of the array using a super-resolution algorithm. A computational model of the array is derived using dyadic Green's function and volume integral method. This application was realized for detecting fatigue cracks, introduced in AISI 304 samples by subjecting them to cyclical loading.