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排序方式: 共有455条查询结果,搜索用时 31 毫秒
1.
Mohammad Bani Ismail Peramaiyan Rajendran Hamad Mohammed AbuZahra Vishnu Priya Veeraraghavan 《International journal of molecular sciences》2021,22(8)
Doxorubicin increases endothelial permeability, hence increasing cardiomyocytes’ exposure to doxorubicin (DOX) and exposing myocytes to more immediate damage. Reactive oxygen species are major effector molecules of doxorubicin’s activity. Mangiferin (MGN) is a xanthone derivative that consists of C-glucosylxanthone with additional antioxidant properties. This particular study assessed the effects of MGN on DOX-induced cytotoxicity in human umbilical vein endothelial cells’ (HUVECs’) signaling networks. Mechanistically, MGN dramatically elevated Nrf2 expression at both the messenger RNA and protein levels through the upregulation of the PI3K/AKT pathway, leading to an increase in Nrf2-downstream genes. Cell apoptosis was assessed with a caspase-3 activity assay, transferase-mediated dUTP-fluorescein nick end labeling (TUNEL) staining was performed to assess DNA fragmentation, and protein expression was determined by Western blot analysis. DOX markedly increased the generation of reactive oxygen species, PARP, caspase-3, and TUNEL-positive cell numbers, but reduced the expression of Bcl-2 and antioxidants’ intracellular concentrations. These were effectively antagonized with MGN (20 μM), which led to HUVECs being protected against DOX-induced apoptosis, partly through the PI3K/AKT-mediated NRF2/HO-1 signaling pathway, which could theoretically protect the vessels from severe DOX toxicity. 相似文献
2.
A. Muthu Manokar M. Vimala D. Prince Winston D. R. Rajendran Ravishankar Sathyamurthy A. E. Kabeel 《亚洲传热研究》2020,49(8):4394-4409
In this paper, an experimental study of the conventional solar still (CSS), the conventional solar still with glass cooling (CSSGC), the conventional solar still with basin heating (CSSBH), and the conventional solar still with glass cooling and basin heating (CSSGCBH) was carried out on the basis of the distilled water production, the energy efficiency (EnE), the exergy efficiency (ExE), and economic analysis. The CSSGC and CSSBH contain Peltier modules for cooling the glass and heating the basin. The evaporative heat transfer coefficient for all the experimental stills was calculated. The values of daily distilled water production from the CSSGCBH, CSSBH, CSSGC, and CSS were 4.56, 3.79, 2.49, and 1.89 kg/m2, respectively. The daily distilled yield of the CSSBH and CSSGCBH were increased by 58.55% and 50.13%, respectively, as compared with the CSS. Moreover, the daily EnE and ExE of the CSSGCBH were 27.03% and 3.5%, respectively, whereas the EnE and ExE of the CSS were 10.88% and 1.3%, respectively. Furthermore, the cost of distilled water production was found to be 0.26, 0.35, 0.53, and 0.64 $/day for the CSS, CSSGC, CSSBH, and CSSGCBH, respectively, if the selling price of the distilled water was Rs10. 相似文献
3.
Rajendran Babhu Vignesh Mathur Gopalakrishnan Sethuraman 《Journal of Coatings Technology and Research》2014,11(4):545-554
Protection of aluminum metal and its alloys from corrosion is a key requirement for many engineering applications. Nowadays, sol–gel coating technology is recognized as the ideal replacement for chromate conversion coatings. The present work makes use of 3-glycidoxypropyltrimethoxysilane (GPTMS) as a precursor for sol–gel coating. GPTMS was subjected to hydrolysis and subsequent condensation reaction to get a three-dimensional network and methylthiourea (MTU) was incorporated into the sol–gel matrix. MTU-doped GPTMS-based sol–gel coatings were applied over aluminum metal by dip coating method. The resultant coating was studied by FTIR, XRD and SEM. MTU-doped GPTMS-based sol–gel coatings increased the hydrophobic nature of the coating and were stable up to a temperature of 450°C. The protective nature of the coatings was evaluated in a 1% NaCl environment using electrochemical impedance and polarization studies. The study has revealed that doping of MTU enhanced the protection ability of doped GPTMS-based sol–gel coating to a significant extent. 相似文献
4.
5.
Rajendran Vaiyapuri Barnaby W Greenland Howard M Colquhoun Joanne M Elliott Wayne Hayes 《Polymer International》2014,63(6):933-942
Efforts to further extend the range of applications of polymer based materials have resulted in the recent production of healable polymers that can regain their strength after damage. Within this field of healable materials, supramolecular polymers have been subject to extensive investigation. By virtue of their reversible non‐covalent interactions, cracks and fractures in such polymers can be readily and repeatedly healed in order to regain key physical properties. However, many supramolecular polymers are relatively weak and elastomeric in nature, which renders them unsuitable for high strength structural applications. To overcome these deficiencies, preliminary studies have shown that it is possible to reinforce supramolecular polymers with microscale and nanoscale fillers to afford composites that are not only stronger and stiffer compared with the polymers alone but also retain their healing abilities. In this minireview we discuss the evolution of these supramolecular composites and their advantages over more conventional, covalent polymeric materials. © 2014 Society of Chemical Industry 相似文献
6.
Aditya Telang P. Deepak Salil Joshi Prasad Deshpande Ranjana Rajendran 《Data mining and knowledge discovery》2014,28(5-6):1480-1502
The last decade has witnessed an unprecedented growth in availability of data having spatio-temporal characteristics. Given the scale and richness of such data, finding spatio-temporal patterns that demonstrate significantly different behavior from their neighbors could be of interest for various application scenarios such as—weather modeling, analyzing spread of disease outbreaks, monitoring traffic congestions, and so on. In this paper, we propose an automated approach of exploring and discovering such anomalous patterns irrespective of the underlying domain from which the data is recovered. Our approach differs significantly from traditional methods of spatial outlier detection, and employs two phases—(i) discovering homogeneous regions, and (ii) evaluating these regions as anomalies based on their statistical difference from a generalized neighborhood. We evaluate the quality of our approach and distinguish it from existing techniques via an extensive experimental evaluation. 相似文献
7.
Avelin Diana A. Sundarakantham K. Mercy Shalinie S. Rajendran L. 《International Journal of Network Management》2014,24(5):402-414
Home agent is a key component of MIPv6 functionality that comprises binding cache to hold the mobile nodes current point of attachment to the Internet. This paper is concerned with binding cache support for home agents within MIPv6 network. Existing binding cache of home agent supports weak cache consistency by using fixed contract length for Binding Refresh Request, which functions reasonably well in normal situations. However, maintaining a strong binding cache consistency in home agent as a crucial exceptional handling mechanism has become more demanding for the following objectives: (i) to adapt increasingly frequent change of care‐of address due to mobile nodes movement detection update; (ii) to provide fine‐grain controls to balance the binding cache load distributions for better delivery services; and (iii) to reduce the overhead allowances around the binding cache. In this paper, we have first verified the effectiveness of Binding Refresh Request contract length, and on the basis of that, two dynamic contract algorithms are suggested to reduce the storage and communication overhead allowances in binding cache. We have also compared our technique with the existing fixed Binding Refresh Request contract length, and our simulation results reveals that the proposed approach provides an effective performance to reduce overhead within the network. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
8.
Dhineshbabu Nattanmai Raman Karunakaran Gopalu Suriyaprabha Rangaraj Manivasakan Palanisamy Rajendran Venkatachalam 《纳微快报(英文)》2014,6(1):46-54
Nano-Micro Letters - Magnesia (MgO) nanoparticles were produced from magnesite ore (MgCO3) using ball mill. The crystalline size, morphology and specific SSA were characterized by X-ray diffraction... 相似文献
9.
Akila Swaminathan Sree Rama Chaitanya Sridhara Swaraj Sinha Shunmugam Nagarajan Uma Maheswari Balaguru Jamila H Siamwala Saranya Rajendran Uttara Saran Suvro Chatterjee 《Journal of food science》2012,77(12):H273-H279
Abstract: Recent evidence has demonstrated that nitrites play an important role in the cardiovascular system. Fennel (Foneiculum vulgare) seeds are often used as mouth fresheners after a meal in both the Indian sub‐continent and around the world. The present study aims to quantify the nitrite and nitrates in fennel seeds as well as elucidating the effect of fennel derived‐nitrites on vascular functions. Results from our study show that fennel seeds contain significantly higher amount of nitrites when compared to other commonly used post‐meal seeds. Furthermore our study confirmed the functional effects of fennel derived‐nitrites using in vitro and ex vivo models that describe the promotion of angiogenesis, cell migration, and vasorelaxation. We also showed that chewing fennel seeds enhanced nitrite content of saliva. Thus our study indicates the potential role of fennel derived‐nitrites on the vascular system. Practical Application: This study is focused on determining the effect of fennel‐derived nitrites on angiogenesis (the formation of new blood vessels from pre‐existing ones), cell migration, and vasorelaxation (dilation of blood vessels) thereby preserving cardiovascular health. 相似文献
10.
Influence of shallow and deep cryogenic treatment on the residual state of stress of 4140 steel 总被引:1,自引:0,他引:1
D. Senthilkumar I. Rajendran M. Pellizzari 《Journal of Materials Processing Technology》2011,211(3):396-401
The present research work studies the effect of cryogenic treatment on the residual stress state in 4140 steel. Two kinds of cryogenic treatment, namely shallow (SCT, −80 °C × 5 h) and deep cryogenic treatment (DCT, −196 °C × 24 h) were carried out between quenching and tempering in conventional heat treatment process. The results evidenced an increase in the compressive residual stress in steel are subjected to cryogenic treatment before tempering. X-ray diffractometry revealed that residual stresses are relieved during tempering, according to the redistribution of carbon in martensite and the precipitation of transition carbides. While conventional heat treatment (CHT) and shallow cryogenic treatment (SCT) promote a tensile state of residual stress, DCT shows a compressive residual stress. 相似文献