Internet of Cultural Things: Current Research,Challenges and Opportunities

Driven by the visions of the Internet of Things (IoT), Artificial Intelligence (AI), and 5G communications, the Internet of Cultural Things (IoCT) realize the comprehensive interconnection among cultural products, cultural services, cultural resources, and cultural platforms, bringing individuals with richer humanistic experience, increasing economic benefits for the cultural sector, and promoting the development of cultural heritage protection and education. At present, IoCT has received widespread attention in both industry and academia. To explore new research opportunities and assist users in constructing suitable IoCT systems for specific applications, this survey provides a comprehensive overview of the IoCT components and key technologies. A comparison study of representative IoCT systems is presented according to their applicability. A general platform architecture of IoCT is proposed to link cultural objects with the internet and human. Finally, open issues for research challenges and future opportunities of IoCT are also studied in this paper.     

Achieving C/CuO microfiber composites with efficient microwave absorbing performance at low thickness

Journal of Materials Science: Materials in Electronics - The carbon fibers with low density still face significant microwave absorbing application issues due to their high dielectric constant....     

Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins

Protein therapy, wherein therapeutic proteins are delivered to treat disorders, is considered the safest and most direct approach for treating diseases. However, its applications are highly limited by the paucity of efficient strategies for delivering proteins and the rapid clearance of therapeutic proteins in vivo after their administration. Here, we demonstrate a novel strategy that can significantly prolong the circulation time of therapeutic proteins as well as minimize their immunogenicity. This is achieved by encapsulating individual protein molecules with a thin layer of crosslinked phosphorylcholine polymer that resists protein adsorption. Through extensive cellular studies, we demonstrate that the crosslinked phosphorylcholine polymer shell effectively prevents the encapsulated protein from being phagocytosed by macrophages, which play an essential role in the clearance of nanoparticles in vivo. Moreover, the polymer shell prevents the encapsulated protein from being identified by immune cells. As a result, immune responses against the therapeutic protein are effectively suppressed. This work describes a feasible method to prolong the circulation time and reduce the immunogenicity of therapeutic proteins, which may promote the development and application of novel protein therapies in the treatment of diverse diseases.

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气垫干燥器内纸幅跑偏的分析及处理

气垫干燥器是利用热能干燥纸幅的设备,用来除去纸张中压榨或其他机械装置不能或很难脱去水份。在传统的纸张和纸板生产工艺中通常使用烘缸组来进一步提高纸张干度,在现今世界上的大中型浆板生产企业则是用气垫干燥器代替烘缸组达到提高浆幅干度的效果。分析纸幅在气垫内的跑偏处理方法。     

变信赖域序列凸规划RLV再入轨迹在线重构

针对可重复使用运载器（RLV）的再入轨迹重构问题,提出一种基于变信赖域序列凸规划的RLV再入轨迹快速求解方法. 首先,通过离散化及对非凸约束的线性化处理,将RLV的非凸轨迹优化问题转换为凸优化问题,然后通过序列凸规划方法对凸优化问题进行求解. 在序列凸规划求解过程的初始迭代中,采用预测校正算法对初值猜测轨迹进行设计,确定轨迹求解的终端时间;在后续迭代过程中,设计基于优化性能指标的信赖域更新策略,提升算法的收敛性能. 在轨迹快速求解方法的基础上,考虑RLV再入过程中可能发生的突发事件,如实际轨迹大幅度偏离参考轨迹或目标点变更,基于变化的初值约束及终端约束在线重构轨迹,并结合重构轨迹和LQR（Linear quadratic regulator）方法设计再入制导律实现对重构轨迹的有效跟踪. 最后,将此设计方法与Gauss伪谱法及传统序列凸规划算法进行仿真对比验证. 仿真结果表明:变信赖域序列凸规划方法相较于伪谱法和传统的序列凸规划方法在轨迹求解实时性及收敛性方面有较大的提升,具备应用于轨迹在线重构的能力,此外,所提出的轨迹在线重构方法具备良好的鲁棒性以及抗扰性.     

基于矿物组分和成岩作用的致密砂岩储层脆性评价方法 ——以鄂尔多斯盆地东北部某区块为例

致密砂岩储层脆性评价对指导压裂施工等具有重要意义。针对目前岩石脆性评价中存在的脆性矿物不明确以及忽略成岩作用对岩石脆性影响的问题,首先根据鄂尔多斯盆地东北部某区块26块岩心样品的薄片、岩心资料和地层条件下的三轴压缩应力实验结果,系统地分析各矿物组分与岩石脆性的关系,明确石英和长石为研究区主要的脆性矿物;其次基于脆性指数与主要脆性矿物具有2种不同的相关关系,明确成岩作用、孔隙发育程度及类型差异对岩石脆性指数的影响;进而综合岩石中成岩矿物对孔隙发育程度及成岩作用的指示作用,利用石英和岩屑含量与长石含量的比值作为成岩作用的分类指标,将研究区致密砂岩储层分为Ⅰ类和Ⅱ类成岩作用储层;最终提出基于矿物组分和成岩作用的致密砂岩储层脆性评价方法,建立相应的脆性指数评价模型。利用该方法对鄂尔多斯盆地某致密气井的致密砂岩储层进行脆性评价,结果表明,基于矿物组分和成岩作用的脆性指数评价模型可以得到更为准确的致密砂岩储层脆性指数,为高脆性有利压裂目的层的识别及增产方案设计提供参数依据。     

海洋环境自动监测的重要手段——小型多参数海洋环境监测浮标

文章简要概述了小型多参数海洋环境监测浮标的结构形式和解决的关键技术以及技术创新点，介绍了其主要功能和达到的技术指标。并对该研究成果的成果转化和应用前景进行了分析和预测。     

Dual‐Locking Nanoparticles Disrupt the PD‐1/PD‐L1 Pathway for Efficient Cancer Immunotherapy

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated (Cas) enzyme, Cas13a, holds great promise in cancer treatment due to its potential for selective destruction of tumor cells via collateral effects after target recognition. However, these collateral effects do not specifically target tumor cells and may cause safety issues when administered systemically. Herein, a dual‐locking nanoparticle (DLNP) that can restrict CRISPR/Cas13a activation to tumor tissues is described. DLNP has a core–shell structure, in which the CRISPR/Cas13a system (plasmid DNA, pDNA) is encapsulated inside the core with a dual‐responsive polymer layer. This polymer layer endows the DLNP with enhanced stability during blood circulation or in normal tissues and facilitates cellular internalization of the CRISPR/Cas13a system and activation of gene editing upon entry into tumor tissue. After carefully screening and optimizing the CRISPR RNA (crRNA) sequence that targets programmed death‐ligand 1 (PD‐L1), DLNP demonstrates the effective activation of T‐cell‐mediated antitumor immunity and the reshaping of immunosuppressive tumor microenvironment (TME) in B16F10‐bearing mice, resulting in significantly enhanced antitumor effect and improved survival rate. Further development by replacing the specific crRNA of target genes can potentially make DLNP a universal platform for the rapid development of safe and efficient cancer immunotherapies.     

Eradication of Multidrug‐Resistant Staphylococcal Infections by Light‐Activatable Micellar Nanocarriers in a Murine Model

Bacterial infections are mostly due to bacteria in their biofilm mode‐of‐growth, making them recalcitrant to antibiotic penetration. In addition, the number of bacterial strains intrinsically resistant to available antibiotics is alarmingly growing. This study reports that micellar nanocarriers with a poly(ethylene glycol) shell fully penetrate staphylococcal biofilms due to their biological invisibility. However, when the shell is complemented with poly(β‐amino ester), these mixed‐shell micelles become positively charged in the low pH environment of a biofilm, allowing not only their penetration but also their accumulation in biofilms without being washed out, as do single‐shell micelles lacking the pH‐adaptive feature. Accordingly, bacterial killing of multidrug resistant staphylococcal biofilms exposed to protoporphyrin IX‐loaded mixed‐shell micelles and after light‐activation is superior compared with single‐shell micelles. Subcutaneous infections in mice, induced with vancomycin‐resistant, bioluminescent staphylococci can be eradicated by daily injection of photoactivatable protoporphyrin IX‐loaded, mixed‐shell micelles in the bloodstream and light‐activation at the infected site. Micelles, which are not degraded by bacterial enzymes in the biofilm, are degraded in the liver and spleen and cleared from the body through the kidneys. Thus, adaptive micellar nanocarriers loaded with light‐activatable antimicrobials constitute a much‐needed alternative to current antibiotic therapies.