Efficient Broadcasting in Mobile Ad Hoc Networks

This paper presents two efficient flooding algorithms based on 1-hop neighbor information. In the first part of the paper, we consider sender-based flooding algorithms, specifically the algorithm proposed by Liu et al. In their paper, Liu et al. propose a sender-based flooding algorithm that can achieve local optimality by selecting the minimum number of forwarding nodes in the lowest computational time complexity O(n logn), where n is the number of neighbors. We show that this optimality only holds for a subclass of sender-based algorithms. We propose an efficient sender-based flooding algorithm based on 1-hop neighbor information that reduces the time complexity of computing forwarding nodes to O(n). In Liu's algorithm, n nodes are selected to forward the message in the worst case, whereas in our proposed algorithm, the number of forwarding nodes in the worst case is 11. In the second part of the paper we propose a simple and highly efficient receiver-based flooding algorithm. When nodes are uniformly distributed, we prove that the probability of two neighbor nodes broadcasting the same messageneighbor nodes broadcasting the same message exponentially decreases when the distance between them decreases or when the node density increases. The analytical results are confirmed using simulation.     

Exact Method for the Error Probability Calculation of Three-Dimensional Signal Constellations

The contribution of this letter is the computation of exact symbol error probability (SEP) of three-dimensional (3-D) signal constellations over an additive white Gaussian noise (AWGN) channel. The originality of the proposed method is that it can be applied to any arbitrary 3-D constellation whose decision regions may not meet at right angles. We express the SEP in a triple integral form which is further simplified. The simplified form requires a single integral evaluation of standard "erf" function. Using the derived exact SEP formula, we plot SEP for a number of selected 3-D constellations. The SEP obtained using the proposed formula is validated by simulation results. It is also compared with the union bound approximation, an upper bound for SEP.     

Synthesis of biotin‐targeted chitosan/poly (methyl vinyl ether‐alt ‐maleic acid) copolymeric micelles for delivery of doxorubicin

Biotinylated chitosan/poly(methyl vinyl ether‐alt ‐maleic acid) (PMVEMA) copolymer was synthesised by an amide reaction in two steps. Structural characterisation was performed using ¹ HNMR and Fourier transform infra‐red (FTIR) spectra. Critical micelle concentration (CMC) of the copolymer was determined by pyrene as a fluorescent probe. Doxorubicin (DOX) was loaded in the micelles by the direct dissolution method. The effects of different variables including type of copolymer, copolymer concentration, stirring rate and stirring time were studied on the physicochemical properties of the micelles including: particle size, zeta potential, release efficiency and loading efficiency of nanoparticles using an irregular factorial design. The in vitro cytotoxicity of DOX‐loaded biotin‐targeted micelles was studied in HepG2 cells which over express biotin receptors by 3, 5‐[dimethylthiazol‐2‐yl]‐2, 5‐diphenyl tetrazolium bromide assay. The successful synthesis of the biotinylated copolymer of chitosan/PMVEMA was confirmed by FTIR and ¹ HNMR. The optimised micelles showed the CMC of 33 μg/ml, particle size of 247 ± 2 nm, zeta potential of +9.46 mV, polydispersity index of 0.22, drug‐loading efficiency of 71% and release efficiency of 84.5 ± 1.6%. The synthesised copolymer was not cytotoxic. The cytotoxicity of DOX‐loaded in targeted micelles on HepG2 cell line was about 2.2‐fold compared with free drug.Inspec keywords: biomedical materials, cellular biophysics, dissolving, drug delivery systems, drugs, electrokinetic effects, fluorescence, Fourier transform infrared spectra, particle size, polymer blends, spectrochemical analysis, toxicologyOther keywords: ¹ HNMR spectra, biotin‐targeted chitosan‐poly (methyl vinyl ether‐alt‐maleic acid) copolymeric micelles, doxorubicin delivery, amide reaction, structural characterisation, Fourier transform infrared spectra, pyrene, fluorescent probe, direct dissolution method, physicochemical properties, particle size, zeta potential, nanoparticles, irregular factorial design, in vitro cytotoxicity, DOX‐loaded biotin‐targeted micelles, 3, 5‐[dimethylthiazol‐2‐yl]‐2, 5‐diphenyl tetrazolium bromide assay, polydispersity index, drug‐loading efficiency, HepG2 cell line, voltage 9.46 mV