2015年世博会卡里塔斯展馆及埃内尔展馆 意大利米兰

正Piuarch建筑师事务所负责设计了2015年米兰世博会埃内尔(意大利国家电力公司)展馆及卡里塔斯展馆。为了将客户想表达的含义与价值观更好地传达给观众,Piuarch选择了一种特殊的建筑语言来体现两个展馆的特点。埃内尔展馆沿东西大街而建,占地900平方米。设计体现出智能电网这一概念,传达出以智能科技优化世博会整体用电的理念。     

Twenty-five years of total antioxidant capacity measurement of foods and biological fluids: merits and limitations

This review summarises 25 years of investigations on antioxidants research in foods and biological fluids and critically analyses the merits and limitations of using the total antioxidant capacity (TAC) measurement in the metabolomic era. An enormous bulk of knowledge was produced regarding the antioxidant capacity of foods and large TAC databases were developed. A direct link between a food TAC value and any health benefit is erroneous and has led to several cases of consumer deception. However, the striking epidemiological evidence associating a high dietary TAC with some disease prevention and the availability of well-constructed TAC databases deserve attention and must be taken into account to establish the usefulness of measuring TAC in both foods and biological samples. The in vivo TAC measurement, usually performed in plasma, is influenced by many external factors, such as dietary habits, as well as environmental and behavioural factors, which are integrated towards homeostatic control by fine physiological mechanisms with high inter-individual variability. Therefore, plasma TAC cannot be considered as a unique biomarker of individual antioxidant status. However, the combined evaluation of plasma TAC with known markers of disease, individual metabolism, inflammation and genetics, as well as with markers of gut microbiota composition and activity, may lead to the identification of populations that are more responsive to food/diet TAC. In this framework, the appropriate use of TAC measurement both in food and in vivo can still provide support for the interpretation of complex phenomena and be a tool for sample screening when making a quick decision toward in-depth research investigations. © 2018 Society of Chemical Industry     

Can regional policies shape migration flows?

Our empirical analysis focuses on the effect of regional policies on migration attraction factors in Europe. We employ a regression discontinuity design to assess the causal relationship between the reception of large amounts of public funds and migration flows in the EU-15 regions. In highly-subsidised regions, we find a large increase in the share of foreign citizens from less-developed countries when compared to low-subsidised regions with similar pre-treatment characteristics. The analysis shows that such an increase is due to the positive impact of the European regional policy on job market opportunities as well as the improvement of public goods supply.     

On the sensitivity of reactive tabu search to its meta-parameters

In this paper, we assess the sensitivity of reactive tabu search to its meta-parameters. Based on a thorough experimental analysis of reactive tabu search applications to the quadratic assignment and the maximum clique problem, we show that its performance is relatively insensitive to its meta-parameters. This is particularly evident when compared to the sensitivity of tabu search to its parameters: tabu search is rather penalized if used with sub-optimal parameter settings. Reactive tabu search does not strongly pay its high parameter robustness in terms of performance, although it does not improve the peak performance of tabu search.     

Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains

Chloroquine is commonly used in the treatment and prevention of malaria, but Plasmodium falciparum, the main species responsible for malaria‐related deaths, has developed resistance against this drug. Twenty‐seven novel chloroquine (CQ) analogues characterized by a side chain terminated with a bulky basic head group, i.e., octahydro‐2H‐quinolizine and 1,2,3,4,5,6‐hexahydro‐1,5‐methano‐8H‐pyrido[1,2‐a][1,5]diazocin‐8‐one, were synthesized and tested for activity against D‐10 (CQ‐susceptible) and W‐2 (CQ‐resistant) strains of P. falciparum. Most compounds were found to be active against both strains with nanomolar or sub‐micromolar IC₅₀ values. Eleven compounds were found to be 2.7‐ to 13.4‐fold more potent than CQ against the W‐2 strain; among them, four cytisine derivatives appear to be of particular interest, as they combine high potency with low cytotoxicity against two human cell lines (HMEC‐1 and HepG2) along with easier synthetic accessibility. Replacement of the 4‐NH group with a sulfur bridge maintained antiplasmodial activity at a lower level, but produced an improvement in the resistance factor. These compounds warrant further investigation as potential drugs for use in the fight against malaria.     

Nutritional aspects of gluten‐free products

In recent years, gluten‐free (GF) goods have become popular, fuelling a growing market, as they not only cater to individuals with medical needs but also to consumers who seek a GF diet. In their development, it is pivotal to pay attention to nutritional quality. This review aims to provide some insights on the nutritional quality of GF products, focusing on major concerns and the strategies to overcome them. In order to mimic the viscoelastic properties of gluten, a large number of flours and starches and other ingredients have been used. Therefore the different mixtures of these ingredients bring a wide difference in the nutritional composition of GF foods with respect to gluten‐containing counterparts. Several GF foodstuffs contain more fat, including saturated, and salt but fewer minerals and vitamins than their equivalents with gluten. The increased fibre content and improved technological processes have positively affected the glycaemic responses from these goods. However, in order to improve their nutritional quality, wholemeal GF cereals and pseudocereals with high nutritive value should replace the low‐nutritional GF flours and consequently the technological processes would be optimized. The improvement of the nutritional quality of GF products, and in turn that of the GF diet, should also be aimed at lowering the risk of later chronic degenerative disorders, especially for infants and young children. © 2015 Society of Chemical Industry     

Stringency of regulation and innovation in waste management: an empirical analysis on EU countries

The transformation of waste into a valuable resource is a key process towards sustainable development and green growth and therefore represents a major concern for policy-makers. Technological innovation plays a crucial role in waste management and therefore understanding the way in which regulation may spur innovation in this domain constitute is crucial. This article aims at testing the weak version of the Porter hypothesis in waste management, by analysing the dynamic relationship between the stringency of environmental regulation and innovation in a European cross-country setting. Results confirm that the stringency of regulation positively affects innovation, but the effect is non-linear, suggesting the existence of an optimal cap to the stringency of regulation. Furthermore, the overall environmental conditions of the country, as well as the presence of highly polluting sectors hinder the development of environmental innovations.     

Effect of warm forming conditions on AZ31B flow behaviour and microstructural characteristics

The paper presents the mechanical and microstructural characterization of the magnesium alloy AZ31B through tests conducted at elevated temperature on a dedicated uni-axial tensile set-up. The samples are heated in-situ through induction heating and their actual deformation is recorded in-line through the Aramis? system. Results from the tests in terms of flow stress, plastic properties and anisotropic coefficients are presented and commented. Additionally, the microstructural analysis on deformed samples in terms of grain size and recrystallized fraction is shown, in order to identify the fundamental mechanisms of dynamic recrystallization and grain growth and to correlate them with the testing parameters. The study provides the best combination of process parameters that can assure, at the same time, good formability and sound microstructure in the warm forming temperature range.     

HCI and education: a blended design experience

Teaching HCI in an undergraduate course for computer scientists is often a challenging experience, because the skills that characterize HCI are different from scientific and computational thinking that are the focus of most subjects of the curriculum. Often HCI teaching is organized as a set of lectures that are useful to learn concepts, but don’t increase the design skills of the students. This work reports the results of an educational experience where both learners and teachers were actively involved in a process of knowledge construction and design. This process usually happens in other domains, such as architecture or industrial design, but is not part of most computer science curricula. We chose as project a challenging theme: the design of eco-feedback interfaces that inform people about the consequences of their actions for the environment and help to take decisions for lowering energy consumption. Eco-feedback interfaces are also representative of the gap between the products available on the market and the results of scientific studies, evidenced also by a recent workshop about HCI education. The workshop evidenced a number of pitfalls in HCI education that in our educational experience we tried to overcome with appropriate methodologies. An additional challenging task was the attempt to organize all the design activities taking advantage of a platform for remote learning, stressing its limits. The paper will discuss all these issues, evidencing where the applied methodologies gave good results and where they need further improvements, with the final goal of giving useful advices for HCI educational experiences to come.