全文获取类型
收费全文 | 4660篇 |
免费 | 145篇 |
国内免费 | 34篇 |
学科分类
工业技术 | 4839篇 |
出版年
2023年 | 36篇 |
2022年 | 43篇 |
2021年 | 103篇 |
2020年 | 78篇 |
2019年 | 50篇 |
2018年 | 73篇 |
2017年 | 62篇 |
2016年 | 67篇 |
2015年 | 66篇 |
2014年 | 88篇 |
2013年 | 144篇 |
2012年 | 131篇 |
2011年 | 158篇 |
2010年 | 126篇 |
2009年 | 109篇 |
2008年 | 134篇 |
2007年 | 109篇 |
2006年 | 125篇 |
2005年 | 90篇 |
2004年 | 91篇 |
2003年 | 100篇 |
2002年 | 98篇 |
2001年 | 65篇 |
2000年 | 64篇 |
1999年 | 66篇 |
1998年 | 156篇 |
1997年 | 91篇 |
1996年 | 88篇 |
1995年 | 71篇 |
1994年 | 83篇 |
1993年 | 55篇 |
1921年 | 34篇 |
1919年 | 35篇 |
1917年 | 48篇 |
1916年 | 78篇 |
1915年 | 88篇 |
1914年 | 54篇 |
1913年 | 61篇 |
1912年 | 82篇 |
1911年 | 84篇 |
1910年 | 94篇 |
1909年 | 97篇 |
1908年 | 102篇 |
1907年 | 101篇 |
1906年 | 94篇 |
1905年 | 118篇 |
1904年 | 150篇 |
1903年 | 94篇 |
1902年 | 65篇 |
1901年 | 74篇 |
排序方式: 共有4839条查询结果,搜索用时 343 毫秒
1.
Abidur Rahman Makoto Kobayashi Kotaro Sugimoto Yuta Endo Manabu Kojima Shigenori Furukawa Takafumi Watanabe Shu Soeda Yuko Hashimoto Keiya Fujimori Hideki Chiba 《International journal of molecular sciences》2021,22(7)
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Methods: We generated a monoclonal Ab (mAb) against human/mouse CLDN12 and verified its specificity. By performing immunohistochemical staining and semiquantification, we evaluated the relationship between CLDN12 expression and clinicopathological parameters in tissues from 138 cases of cervical cancer. Results: Western blot and immunohistochemical analyses revealed that the established mAb selectively recognized the CLDN12 protein. Twenty six of the 138 cases (18.8%) showed low CLDN12 expression, and the disease-specific survival (DSS) and recurrence-free survival rates were significantly decreased compared with those in the high CLDN12 expression group. We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively). Conclusions: It can be concluded that a reduced CLDN12 expression predicts a poor outcome for cervical cancer. The novel anti-CLDN12 mAb could be a valuable tool to evaluate the biological relevance of the CLDN12 expression in diverse cancer types and other diseases. 相似文献
2.
Noriyuki Wada Jyoji Hanai Mikiya Furukawa Kazuo Kojima 《Journal of the American Ceramic Society》2019,102(8):4621-4631
To make a Mn2+-doped red glass phosphor that can be excited with ultraviolet (UV) light of light-emitting diodes (LEDs), 60P2O5-35ZnO-5Al2O3-8MnO-xCu2O glasses (x = 0-1.00) were prepared by a melt-quenching method at 1200-1400°C for 30-180 minutes in atmospheric air, and the redox of Mn and Cu as well as fluorescence properties were investigated. The Mn2+ ion was not reduced and oxidized in the melting, quenching, and annealing processes. The valence of Cu in the glasses changed in the order of 0, 1+, and 2+ with the increase in the amount of Cu2O and in the melting temperature and time. In this study, a 60P2O5-35ZnO-5Al2O3-8MnO-0.10Cu2O glass melted at 1250°C for 90 minutes, having the highest Cu+ concentration, showed the strongest Mn2+ red fluorescence under the UV light at 275 nm. This strong Mn2+ red fluorescence has been caused by the energy transfer from excited Cu+ ions to Mn2+ ions. 相似文献
3.
Mie Kurosawa Yosuke Shikama Masae Furukawa Rieko Arakaki Naozumi Ishimaru Kenji Matsushita 《International journal of molecular sciences》2021,22(5)
Immunosenescence is characterized by age-associated changes in immunological functions. Although age- and autoimmune-related sialadenitis cause dry mouth (xerostomia), the roles of immunosenescence and cellular senescence in the pathogenesis of sialadenitis remain unknown. We demonstrated that acquired immune cells rather than innate immune cells infiltrated the salivary glands (SG) of aged mice. An analysis of isolated epithelial cells from SG revealed that the expression levels of the chemokine CXCL13 were elevated in aged mice. Senescence-associated T cells (SA-Ts), which secrete large amounts of atypical pro-inflammatory cytokines, are involved in the pathogenesis of metabolic disorders and autoimmune diseases. The present results showed that SA-Ts and B cells, which express the CXCL13 receptor CXCR5, accumulated in the SG of aged mice, particularly females. CD4+ T cells derived from aged mice exhibited stronger in vitro migratory activity toward CXCL13 than those from young mice. In a mouse model of Sjögren’s syndrome (SS), SA-Ts also accumulated in SG, presumably via CXCL12-CXCR4 signaling. Collectively, the present results indicate that SA-Ts accumulate in SG, contribute to the pathogenesis of age- and SS-related sialadenitis by up-regulating chemokines in epithelial cells, and have potential as therapeutic targets for the treatment of xerostomia caused by these types of sialadenitis. 相似文献
4.
Ajit Sharma Doan Van Thuan Thanh-Dong Pham Mai Hung Thanh Tung Nguyen Thi Thanh Truc Dai-Viet N. Vo 《化学工程与技术》2020,43(4):752-761
FeO-doped TiO2 nanoparticle photocatalysts were immobilized onto the surface of fibrous activated carbon (ACF) via a sol-gel process. As an adsorbent and photocatalyst, FeO-TiO2 on immobilized ACFs (FeO-TiO2/ACF) greatly improved the photocatalysis rate of hydrogen production as compared with pure TiO2 and ACF-TiO2 under UV irradiation and visible light. The addition of ACFs surface significantly reduced the photogenerated pairs of electrons-hole recombination, thereby promoting the photocatalysis action of doped photo-metal oxides of FeO-TiO2. Co-doping of FeO onto the lattice of the TiO2 approach can improve the absorption activity of visible light through photo-metal oxide of TiO2 and further enhance hydrogen production under visible light. The photocatalytic fabrics (FeO-TiO2/ACF) were effortlessly split out from the experimental solution for re-utilization and exhibited high stability even after five complete regeneration cycles. 相似文献
5.
6.
Tanabe A. Nakahara Y. Furukawa A. Mogami T. 《Solid-State Circuits, IEEE Journal of》2003,38(1):107-113
A redundant multivalued logic is proposed for high-speed communication ICs. In this logic, serial binary data are received and converted into parallel redundant multivalued data. Then they are restored into parallel binary data. Because of the multivalued data conversion, this logic makes it possible to achieve higher operating speeds than that of a conventional binary logic. Using this logic, a 1:4 demultiplexer (DEMUX, serial-parallel converter) IC was fabricated using a 0.18-/spl mu/m CMOS process. The IC achieved an operating speed of 10 Gb/s with a supply voltage of only 1.3 V and with power consumption of 38 mW. This logic may achieve CMOS communication ICs with an operating speed several times greater than 10 Gb/s. 相似文献
7.
8.
一、SQL简介 如果说七十年代关系数据库还处于研制实验阶段,那么到了八十年代大量关系数据库商用产品的面市几乎占据了整个数据库市场,其中的原因在于它们使用了统一的语言界面,那就是,SQL成为了关系数据库的通用语言。 1974年.IBM公司San Jose研究实验室的D.D.Chamberlin在开发SEQUEL-XRM原型时提出了SE-QUEL(Structured English Query Language),1976年又修改成为SEQUEL/2.也就是目前的SQL(StructuredQuer Language)。SEQUEL/2主要成形于IBM的Sys-tem R原型中[2],并在原有基础上大加扩展,其后逐渐完善并最终成为一种完备的结构化数据库查询语言。 相似文献
9.
中国珠宝销售的可持续发展 总被引:2,自引:1,他引:1
通过对改革开放20多年来中国珠宝业发展的回顾与分析, 认为在激烈的市场竞争中, 珠宝业要达到可持续发展必须具备6个要素: (1)敬业精神; (2)信用意识; (3)创新意识和创新能力; (4)激励机制和团队精神; (5)资本营运和资源整合能力; (6)关系营销技巧. 相似文献
10.
The state of the art of debugging is examined. A debugged process model that serves as the basis of a general debugging framework is described. The relationship of the model to traditional debugging processes and support tools is discussed. A minimal set of requirements for a general debugging framework is described in terms of both the theory behind debugging methodologies and the support tools. An execution monitor, Eden, that serves as a debugging tool within this general framework is described 相似文献