全文获取类型
收费全文 | 880篇 |
免费 | 11篇 |
国内免费 | 1篇 |
学科分类
工业技术 | 892篇 |
出版年
2023年 | 4篇 |
2021年 | 7篇 |
2020年 | 4篇 |
2019年 | 8篇 |
2018年 | 11篇 |
2017年 | 7篇 |
2016年 | 11篇 |
2015年 | 9篇 |
2014年 | 6篇 |
2013年 | 38篇 |
2012年 | 27篇 |
2011年 | 28篇 |
2010年 | 21篇 |
2009年 | 21篇 |
2008年 | 36篇 |
2007年 | 28篇 |
2006年 | 37篇 |
2005年 | 34篇 |
2004年 | 25篇 |
2003年 | 28篇 |
2002年 | 20篇 |
2001年 | 18篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 100篇 |
1997年 | 59篇 |
1996年 | 51篇 |
1995年 | 31篇 |
1994年 | 30篇 |
1993年 | 26篇 |
1992年 | 5篇 |
1991年 | 9篇 |
1990年 | 8篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1987年 | 11篇 |
1986年 | 9篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 10篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 6篇 |
1977年 | 7篇 |
1976年 | 11篇 |
1972年 | 2篇 |
1970年 | 3篇 |
1969年 | 2篇 |
排序方式: 共有892条查询结果,搜索用时 15 毫秒
1.
Abidur Rahman Makoto Kobayashi Kotaro Sugimoto Yuta Endo Manabu Kojima Shigenori Furukawa Takafumi Watanabe Shu Soeda Yuko Hashimoto Keiya Fujimori Hideki Chiba 《International journal of molecular sciences》2021,22(7)
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Methods: We generated a monoclonal Ab (mAb) against human/mouse CLDN12 and verified its specificity. By performing immunohistochemical staining and semiquantification, we evaluated the relationship between CLDN12 expression and clinicopathological parameters in tissues from 138 cases of cervical cancer. Results: Western blot and immunohistochemical analyses revealed that the established mAb selectively recognized the CLDN12 protein. Twenty six of the 138 cases (18.8%) showed low CLDN12 expression, and the disease-specific survival (DSS) and recurrence-free survival rates were significantly decreased compared with those in the high CLDN12 expression group. We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively). Conclusions: It can be concluded that a reduced CLDN12 expression predicts a poor outcome for cervical cancer. The novel anti-CLDN12 mAb could be a valuable tool to evaluate the biological relevance of the CLDN12 expression in diverse cancer types and other diseases. 相似文献
2.
Mie Kurosawa Yosuke Shikama Masae Furukawa Rieko Arakaki Naozumi Ishimaru Kenji Matsushita 《International journal of molecular sciences》2021,22(5)
Immunosenescence is characterized by age-associated changes in immunological functions. Although age- and autoimmune-related sialadenitis cause dry mouth (xerostomia), the roles of immunosenescence and cellular senescence in the pathogenesis of sialadenitis remain unknown. We demonstrated that acquired immune cells rather than innate immune cells infiltrated the salivary glands (SG) of aged mice. An analysis of isolated epithelial cells from SG revealed that the expression levels of the chemokine CXCL13 were elevated in aged mice. Senescence-associated T cells (SA-Ts), which secrete large amounts of atypical pro-inflammatory cytokines, are involved in the pathogenesis of metabolic disorders and autoimmune diseases. The present results showed that SA-Ts and B cells, which express the CXCL13 receptor CXCR5, accumulated in the SG of aged mice, particularly females. CD4+ T cells derived from aged mice exhibited stronger in vitro migratory activity toward CXCL13 than those from young mice. In a mouse model of Sjögren’s syndrome (SS), SA-Ts also accumulated in SG, presumably via CXCL12-CXCR4 signaling. Collectively, the present results indicate that SA-Ts accumulate in SG, contribute to the pathogenesis of age- and SS-related sialadenitis by up-regulating chemokines in epithelial cells, and have potential as therapeutic targets for the treatment of xerostomia caused by these types of sialadenitis. 相似文献
3.
Md Sazzadur Rahman MD Nahin Islam Shiblee Kumkum Ahmed Ajit Khosla Jun Ogawa Masaru Kawakami Hidemitsu Furukawa 《大分子材料与工程》2020,305(9)
In this work, 3D printable gel polymer electrolytes (GPEs) based on N,N‐dimethylacrylamide (DMAAm) and polyvinylidene fluoride (PVDF) in lithium chloride containing ethylene glycol solution are synthesized and their physicochemical properties are investigated. 3D printing is carried out with a customized stereolithography type 3D gel printer named “Soft and Wet Intelligent Matter‐Easy Realizer” and free forming GPE samples having variable shapes and sizes are obtained. Printed PVDF/PDMAAm‐based GPEs exhibit tunable mechanical properties and favorable thermal stability. Electrochemical proprieties of the printed GPEs are carried out via impedance spectroscopy in the temperature range of 25–90 °C by varying PVDF content. Ionic conductivity as high as 6.5 × 10?4 S cm?1 is achieved at room temperature for GPE containing low PVDF content (5 wt%) and conductivity of the GPEs is increased as temperature rises. 相似文献
4.
5.
Noriyuki Wada Jyoji Hanai Mikiya Furukawa Kazuo Kojima 《Journal of the American Ceramic Society》2019,102(8):4621-4631
To make a Mn2+-doped red glass phosphor that can be excited with ultraviolet (UV) light of light-emitting diodes (LEDs), 60P2O5-35ZnO-5Al2O3-8MnO-xCu2O glasses (x = 0-1.00) were prepared by a melt-quenching method at 1200-1400°C for 30-180 minutes in atmospheric air, and the redox of Mn and Cu as well as fluorescence properties were investigated. The Mn2+ ion was not reduced and oxidized in the melting, quenching, and annealing processes. The valence of Cu in the glasses changed in the order of 0, 1+, and 2+ with the increase in the amount of Cu2O and in the melting temperature and time. In this study, a 60P2O5-35ZnO-5Al2O3-8MnO-0.10Cu2O glass melted at 1250°C for 90 minutes, having the highest Cu+ concentration, showed the strongest Mn2+ red fluorescence under the UV light at 275 nm. This strong Mn2+ red fluorescence has been caused by the energy transfer from excited Cu+ ions to Mn2+ ions. 相似文献
6.
7.
Jonathan Hodges Tamer Attia Janindu Arukgoda Changkoo Kang Mickey Cowden Luan Doan Ravindra Ranasinghe Karim Abdelatty Gamini Dissanayake Tomonari Furukawa 《野外机器人技术杂志》2019,36(1):183-203
This paper presents a generalized multistage bayesian framework to enable an autonomous robot to complete high‐precision operations on a static target in a large field. The proposed framework consists of two multistage approaches, capable of dealing with the complexity of high‐precision operation in a large field to detect and localize the target. In the multistage localization, locations of the robot and the target are estimated sequentially when the target is far away from the robot, whereas these locations are estimated simultaneously when the target is close. A level of confidence (LOC) for each detection criterion of a sensor and the associated probability of detection (POD) of the sensor are defined to make the target detectable with different LOCs at varying distances. Differential entropies of the robot and target are used as a precision metric for evaluating the performance of the proposed approach. The proposed multistage observation and localization approaches were applied to scenarios using an unmanned ground vehicle (UGV) and an unmanned aerial vehicle (UAV). Results with the UGV in simulated environments and then real environments show the effectiveness of the proposed approaches to real‐world problems. A successful demonstration using the UAV is also presented. 相似文献
8.
9.
Li Zhang Jiachun Yang Yongguang Ma Zhigang Li Takao Fujii Wenjie Zhang Nishiyama Takashi Kenji Furukawa 《Journal of Bioscience and Bioengineering》2010,110(1):72-78
The feasibility of applying a polyethylene (PE) sponge as a biomass carrier in an anaerobic ammonium oxidation (anammox) reactor and its nitrogen removal performance were also investigated. Experiments were carried out in an up-flow column reactor with synthetic inorganic wastewater. Experimental results indicate that reactor containing PE sponge biomass carriers showed a high nitrogen removal capability and exhibited stable performance. In addition, the reactor with 8 strips PE sponge as biomass carrier exhibited greater adaptation capacity compared to that with 6 strips and could achieve a high TN removal rate within a very short period. The ratio of NO2-N removal and NO3-N production to NH4-N removal for the reactor was 1.26:0.21. Furthermore, to investigate the bacterial composition of the mature community, 16S rRNA sequences were amplified by PCR and analyses were conducted using DNA databases. Results showed that a new kind of anammox microorganism (Kumadai-1) was the dominant species in the reactor when using PE sponge as a biomass carrier. 相似文献
10.
Shizue Furukawa Mikimasa Iwata Kazuo Adachi Tadashi Amakawa 《Electrical Engineering in Japan》2010,170(2):46-52
We investigated by numerical analysis the dependence of vaporization behavior of aluminum particles injected into transferred type arc plasma on injection conditions in synthesis of aluminum nitride ultra fine particles. On the basis of calculation results, we chose one proper injection condition where aluminum particles vaporized more. © 2009 Wiley Periodicals, Inc. Electr Eng Jpn, 170(2): 46–52, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20852 相似文献