Lysophosphatidic acid (lysoPtdOH) levels have previously been reported to decrease in rodents with short-term fasting. We investigated whether a 16 h fast would change expression of autotaxin, the predominant phospholipase D responsible for adipose-derived lysoPtdOH synthesis, or any of the lysophosphatidic acid receptors (1–6) in four white adipose tissue (WAT) depots and interscapular brown adipose tissue (BAT) in male C57Bl/6J mice fed ad libitum, or fasted for 16 h. Aside from small inductions of Lpar1 in epididymal WAT and Lpar2 in epididymal and inguinal WAT, no significant changes were observed in expression of the Lpar family members, or autotaxin in perirenal, retroperitoneal, epididymal, or inguinal WAT or BAT with fasting. Comparison of the relative expression of Lpar1-6 in various depots showed that Lpar6 was the predominant Lpar in both WAT and BAT, and suggests that further work on the adipose-specific role of Lpar6 is warranted. 相似文献
Wave absorbers are considered to be fundamental building blocks for the manipulation of light. Almost all optical systems exploit absorbers to realize some functions. A highly tunable wide-band THz absorber is presented herein. Utilizing a dual-bias scheme with a single graphene layer leads to greater freedom to control the absorption response, while a conventional periodic array of graphene ribbons and a layer of graphene sheet are also exploited. Also, a circuit model representation for all the constituent parts of the proposed absorber is developed with an evolved design methodology. According to the simulation results, wide-band absorption from 3.5 to 6 THz is achieved.
Deriving the optimal policies of hydropower multi-reservoir systems is a nonlinear and high-dimensional problem which makes it difficult to achieve the global or near global optimal solution. In order to optimally solve the problem effectively, development of optimization methods with the purpose of optimizing reservoir operation is indispensable as well as inevitable. This paper introduces an enhanced differential evolution (EDE) algorithm to enhance the exploration and exploitation abilities of the original differential evolution (DE) algorithm. The EDE algorithm is first applied to minimize two benchmark functions (Ackley and Shifted Schwefel). In addition, a real world two-reservoir hydropower optimization problem and a large scale benchmark problem, namely ten-reservoir problem, were considered to indicate the effectiveness of the EDE. The performance of the EDE was compared with the original DE to solve the three optimization problems. The results demonstrate that the EDE would have a powerful global ability and faster convergence than the original DE to solve the two benchmark functions. In the 10-reservoir optimization problem, the EDE proved to be much more functional to reach optimal or near optimal solution and to be effective in terms of convergence rate, standard deviation, the best, average and worst values of objective function than the original DE. Also, In the case of two-reservoir system, the best values of the objective function obtained 93.86 and 101.09 for EDE and DE respectively. Based on the results, it can be stated that the most important reason to improve the performance of the EDE algorithm is the promotion of local and global search abilities of the DE algorithm using the number of novel operators. Also, the results of these three problems corroborated the superior performance, the high efficiency and robustness of the EDE to optimize complex and large scale multi-reservoir operation problems. 相似文献
In this paper, we consider the problem of flocking and shape‐orientation control of multi‐agent systems with inter‐agent and obstacle collision avoidance. We first consider the problem of forcing a set of autonomous agents to form a desired formation shape and orientation while avoiding inter‐agent collision and collision with convex obstacles, and following a trajectory known to only one of the agents, namely the leader of the formation. Then we build upon the solution given to this problem and solve the problem of guaranteeing obstacle collision avoidance by changing the size and the orientation of the formation. Changing the size and the orientation of the formation is helpful when the agents want to go through a narrow passage while the existing size or orientation of the formation does not allow this. We also propose collision avoidance algorithms that temporarily change the shape of the formation to avoid collision with stationary or moving nonconvex obstacles. Simulation results are presented to show the performance of the proposed control laws. 相似文献
The precision of a closed‐loop controller system designed for an uncertain plant depends strongly upon the maximum extent to which it is possible to track the trend of time‐varying parameters of the plant. The aim of this study is to describe a new parameter estimation algorithm that is able to follow fast‐varying parameters in closed‐loop systems. The short‐time linear quadratic form (STLQF) estimation algorithm introduced in this paper is a technique for tracking time‐varying parameters based on short‐time analysis of the regressing variables in order to minimize locally a linear quadratic form cost function. The established cost function produces a linear combination of errors with several delays. To meet this objective, mathematical development of the STLQF estimation algorithm is described. To implement the STLQF algorithm, the algorithm is applied to a planar mobile robot with fast‐varying parameters of inertia and viscous and coulomb frictions. Next, performance of the proposed algorithm is assessed against noise effects and variation in the type of parameters. 相似文献
This paper proposes a new single-phase direct step-up ac–ac converter by modifying the p-type impedance source. It provides a high boost factor as well as high efficiency, while only six parts are required to design it, involving just two bidirectional power switches. A safe commutation method has been applied to power switches to make the converter snubber-free and high efficient. Input and output harmonic filters are no longer required since input and output currents variate continuously with small ripple and low total harmonic distortion (THD). The proposed topology only modulates the output voltage amplitude, not the phase and frequency, so the output frequency is identical to the input frequency and constant. Thus, it can be utilized in step-up conversion applications, like inductive power transmission from low ac voltage sources. Input and output have the same ground, which is a good protective feature. In this paper, the operating principle of the converter is demonstrated. Experimental results have been represented to evaluate the performance of the converter. For this purpose, an experimental prototype has been fabricated. Results are investigated and compared with other previous step-up ac–ac converters. Results confirm the theory, operating principle, and performance of the converter. 相似文献
In most countries, the main step in the process of power system restoration, following a complete/partial blackout, is energization of primary restorative transmission lines. Artificial neural network (ANN) is employed for performing a nonlinear input–output mapping in this work, in order to estimate the temporary overvoltages (TOVs) due to transmission lines energization. In the proposed methodology, Levenberg–Marquardt second order method is used to train the multilayer perceptron. Proposed ANN is trained with equivalent circuit parameters of the network as input parameters, trained ANN has therefore satisfactory generalization capability. Both single and three-phase line energizations are analyzed. The simulated results for 39-bus New England test system, indicate that the proposed technique can estimate the peak values and duration of switching overvoltages with acceptable accuracy. 相似文献
At universities where students enjoy flexibility in selecting courses, the Registrar’s office aims to generate an appropriate
exam timetable for numerous courses and large number of students. An appropriate, real-world exam timetable should show fairness
towards all students, respecting the following constraints: (a) eliminating or minimizing the number of simultaneous exams;
(b) minimizing the number of consecutive exams; (c) minimizing the number of students with two or three exams per day (d) eliminating
the possibility of more than three exams per day (e) exams should fit in rooms with predefined capacity; and (f) the number
of exam periods is limited. These constraints are conflicting, which makes exam timetabling intractable. Hence, solving this
problem in realistic time requires the use of heuristic approaches. In this work, we develop an evolutionary heuristic technique
based on the scatter search approach for finding good suboptimal solutions for exam timetabling. This approach is based on
maintaining and evolving a population of solutions. We evaluate our suggested technique on real-world university data and
compare our results with the registrar’s manual timetable in addition to the timetables of other heuristic optimization algorithms.
The experimental results show that our adapted scatter search technique generates better timetables than those produced by
the registrar, manually, and by other meta-heuristics. 相似文献