Short-term power sources for tokamaks and other physical experiments

The Compass-D tokamak is being planned to move from UKAEA Culham (England) be and reinstalled in IPP Prague (Czech Republic). An overview of Compass-D energetics is described in short. The new power sources have to be designed. Alternative solutions of power sources have been investigated. Ignitrons and mechanical breakers can be replaced by modern high-power semiconductors. With respect to the need of accumulated energy, new technologies of energy storage - supercapacitors and high-speed flywheels, not applied up to now in similar fusion projects, are characterized in comparison with traditional ones - capacitors and big motor-flywheel generators. It is shown that these technologies enhance possibilities in arrangement of power supplies for tokamaks as well as for other high-power demanding experiments with pulse length from fraction to tens of seconds.     

A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin

Doxorubicin is a commonly used antineoplastic agent in the treatment of many types of cancer. Little is known about the interactions of doxorubicin with cardiac biomolecules. Serious cardiotoxicity including dilated cardiomyopathy often resulting in a fatal congestive heart failure may occur as a consequence of chemotherapy with doxorubicin. The purpose of this study was to determine the effect of exposure to doxorubicin on the changes in major amino acids in tissue of cardiac muscle (proline, taurine, glutamic acid, arginine, aspartic acid, leucine, glycine, valine, alanine, isoleucine, threonine, lysine and serine). An in vitro interaction study was performed as a comparison of amino acid profiles in heart tissue before and after application of doxorubicin. We found that doxorubicin directly influences myocardial amino acid representation even at low concentrations. In addition, we performed an interaction study that resulted in the determination of breaking points for each of analyzed amino acids. Lysine, arginine, β-alanine, valine and serine were determined as the most sensitive amino acids. Additionally we compared amino acid profiles of myocardium before and after exposure to doxorubicin. The amount of amino acids after interaction with doxorubicin was significantly reduced (p = 0.05). This fact points at an ability of doxorubicin to induce changes in quantitative composition of amino acids in myocardium. Moreover, this confirms that the interactions between doxorubicin and amino acids may act as another factor most likely responsible for adverse effects of doxorubicin on myocardium.     

In-line catalytic derivatization method for selective detection of chlorinated aromatics with a hyphenated gas chromatography/laser mass spectrometry technique: a concept for comprehensive detection of isomeric ensembles

The combination of gas chromatography (GC) and laser-based resonance-enhanced multiphoton ionization-time-of-flight mass spectrometry (REMPI-TOFMS) represents a three-dimensional analytical method, using the gas chromatographic retention time, the wavelength of the ionization laser for REMPI, and the molecular mass as analytical parameters. In this work, a novel analytical scheme for detection of chlorinated aromatic compounds, including isomeric ensembles, by GC/REMPI-TOFMS is presented. The concept uses an in-line hydrodechlorination catalyst for post- or precolumn derivatization of chlorinated aromatic compounds. The chlorinated aromatics are quantitatively reduced, forming their respective aromatic skeletons. These aromatic skeletons are detected selectively by REMPI-TOFMS. The first results for substance class selective detection of chlorinated benzene isomers are given, and potential applications in the field of the analysis of compounds such as polychlorinated dibenzo-p-dioxins and -furans are discussed.     

Holzinger, A.: Basiswissen Multimedia Bd. 1: Technik. Zahlir Abb., 284 S. ISBN 3-8023-1856-0; Bd. 2: Lernen. Zahlr. Abb., 290 S. ISBN 3-8023-1857-0; Bd. 3: Design. Zahlr. Abb., 280 S. ISBN 3-8023-1858-0. Vogl, Würzburg, 2000. DM 59,-, ATS 431,- (je Band)

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Holzinger, A.: Basiswissen Multimedia Bd. 1: Technik. Zahlir Abb., 284 S. ISBN 3-8023-1856-0; Bd. 2: Lernen. Zahlr. Abb., 290 S. ISBN 3-8023-1857-0; Bd. 3: Design. Zahlr. Abb., 280 S. ISBN 3-8023-1858-0. Vogl, Würzburg, 2000. DM 59,-, ATS 431,- (je Band)     

Integrated simulation method for investment decisions of micro production systems

From a production logistics point of view, micro production systems need special methods due to their special requirements and characteristics. In this paper a new approach for the assessment of different investment scenarios during the planning period with integrated cost simulation is presented. In particular, the use of single-purpose and multi-purpose machines and the cost effectiveness of function integration are examined. Thereby alternative machine pool configurations and optimal costs can be analysed, determined and taken into consideration for investment decisions.