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排序方式: 共有1778条查询结果,搜索用时 31 毫秒
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Anna Stasiowicz Natalia Rosiak Ewa Tykarska Maciej Kozak Jacek Jenczyk Piotr Szulc Joanna Kobus-Cisowska Kornelia Lewandowska Anita Paziska Wojciech Paziski Judyta Cielecka-Piontek 《International journal of molecular sciences》2021,22(8)
Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood–brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase). 相似文献
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Stawarz Sylwester Witek Natalia Kucharczyk Wojciech Bakar Mohamed Stawarz Magdalena 《International Journal of Mechanics and Materials in Design》2019,15(3):585-599
International Journal of Mechanics and Materials in Design - The present work investigates the ablative and thermal properties of an epoxy resin which was modified with titanium dioxide... 相似文献
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Pyrolysis experiments were performed in high vacuum and under reduced air pressure (100 Pa). The volatile products of pure cellulose and cellulose containing various amounts of flame retardant 2,2′-oxybis (5,5-dimethyl-1,3,2-dioxaphosphorinane-2,2′-disulfide), i.e., Sandoflam 5060 of Sandoz AG, were studied by means of gas chromatography in combination with mass spectroscopy. The volatile products were characterized with infrared spectroscopy. The studied revealed that the incorporation of the flame retardant enhanced the water release and shifted the onset of this reaction to lower temperature. On the basis of these findings an explanation for the mechanism of flame retardancy in generated cellulose fibers modified with this particular flame retardant is attempted. From experiments with different residual air pressure the influence of oxygen on the primary processes of the pyrolytic degradation of cellulose is being discussed. 相似文献
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High-speed air breathing propulsion systems have many attractive military and civil applications. The high propulsive efficiency of these systems allows the exploitation of speed, distance, and bigger payloads, or any combination of the three. The severe operating conditions of these systems require particular attention to overall thermal management of the engine/air-frame. Fuel-cooling the engine structure is a viable way of maintaining thermal balance over a range of flight conditions. Air Force applications have focused on using endothermic hydrocarbon fuels to address this issue because of their compatibility with the military operations. Recent ground tests of scramjet engines have demonstrated adequate performance utilizing state-of-the-art technology in materials. This progress has paved the way for an expendable flight test vehicle in the near future. In order to take full advantage of the capabilities of this propulsion system, advances in fuel-cooled structures, high temperature un-cooled materials, and increased heat capacity of hydrocarbon fuels will be needed to enable expendable systems to reach higher Mach numbers. An additional benefit would be realized in future reusable systems. 相似文献
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Natalia Andronova 《Polymer》2005,46(18):6746-6755
The synthesis and characterization of degradable polymeric networks for biomedical applications was performed. Cross-linked films of poly(ε-caprolactone) (PCL) and poly(1,5-dioxepan-2-one) (PDXO) having various mole fractions of monomers and different cross-link densities were successfully prepared using 2,2′-bis-(ε-caprolactone-4-yl) propane (BCP) as cross-linking agent. Reaction parameters were carefully examined to optimise the film-forming conditions. Networks obtained were elastomeric materials, easy to cast and remove from the mould. Effect of CL content and cross-link density on the final properties of the polymer network was evaluated. High CL content or degree of cross-linking led to increase in Young's modulus and decrease in elongation at break. An increase in crystalline domains in films having a higher CL content was observed by optical microscopy. A greater thermal stability was observed in films having a high CL content. The hydrophilicity of the materials could be tailored by changing the CL content. The surface of the films became rougher with higher CL content. 相似文献
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A novel approach is presented to calculate the sensitivities of the scattering parameters of microwave filters obtained with the full‐wave mode‐matching (MM) technique. Using only the MM simulation of the original network, the sensitivities of the scattering parameters with respect to all designable parameters are obtained. The adjoint network method (ANM) is applied to the generalized scattering matrices of the different filter components. This guarantees good accuracy of the calculated sensitivities. The implementation details are discussed for N‐resonator ridge waveguide filters. Excellent agreement is obtained between the sensitivities calculated using ANM and those obtained using the expensive central differences. © 2006 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2006. 相似文献
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Bruce K. Fink Roy L. McCullough John W. Gillespie 《Polymer Engineering and Science》1992,32(5):357-369
For joining and repair of continuous fiber thermoplastic composites, induction heating has been viewed a strong candidate. Induction heating employs an applied alternating magnetic field, which induces a rotational emf in a grid of conductive carbon fibers, which are then used to carry resulting currents. In continuous carbon fiber crossply composites the available paths for “eddy current” loops are along the network of conductive carbon fibers. For this to occur, an electrical transfer must take place between crossing fibers in adjacent plies. Tests involving variable thicknesses of interply neat film layers have been performed to provide insight into the mechanisms taking place. These tests indicate that the primary mechanism for heating in such laminates is dielectric losses in the polymeric region between fibers in adjacent planes that form the conductive loop. Therefore, heating is not uniform in such composites despite a uniform magnetic flux. Heating patterns were viewed using liquid crystal materials and E-type thermocouples. Several factors leading to nonhomogeneous thermal distributions have been considered, including current density effects, internal emf cancellation, and rotational field effects. Global and local considerations are addressed, a localized model is proposed, and the corresponding theory is developed qualifying the early results. Additional testing has supported the theory. 相似文献