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排序方式: 共有643条查询结果,搜索用时 281 毫秒
1.
Milena Jankovic Ivana Novakovic Dejan Nikolic Jasmina Mitrovic Maksic Slavko Brankovic Ivana Petronic Dragana Cirovic Sinisa Ducic Mirko Grajic Dragana Bogicevic 《International journal of molecular sciences》2021,22(9)
Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping they will become significant for diagnosis, therapy and prevention of DN. 相似文献
2.
Fabiana D'Isanto Federico Smeacetto Hans-Peter Martin Richard Sedlák Maksym Lisnichuk Andreas Chrysanthou Milena Salvo 《Ceramics International》2021,47(14):19774-19783
A silica-based glass-ceramic, with Y2Ti2O7 as the major crystalline phase, is designed, characterised and tested as an oxidation-protective coating for a titanium suboxide (TiOx) thermoelectric material at temperatures of up to 600 °C. The optimised sinter-crystallisation treatment temperatures are found to be 1300 °C and 855 °C for a duration of 30 min, and this treatment leads to a glass-ceramic with cubic Y2Ti2O7 and CaAl2Si2O8 as crystalline phases. An increase of ~270 °C in the dilatometric softening temperature is observed after devitrification of the parent glass, thus further extending its working temperature range.Excellent adhesion of the glass-ceramic coating to the thermoelectric material is maintained after exposure to a temperature of 600 °C for 120 h under oxidising conditions, thus confirming the effectiveness of the T1 glass-ceramic in protecting the TiOx material. 相似文献
3.
Celia Nieto Milena A. Vega Eva M. Martín del Valle 《International journal of molecular sciences》2021,22(6)
Ferroptosis is gaining followers as mechanism of selective killing cancer cells in a non-apoptotic manner, and novel nanosystems capable of inducing this iron-dependent death are being increasingly developed. Among them, polydopamine nanoparticles (PDA NPs) are arousing interest, since they have great capability of chelating iron. In this work, PDA NPs were loaded with Fe3+ at different pH values to assess the importance that the pH may have in determining their therapeutic activity and selectivity. In addition, doxorubicin was also loaded to the nanoparticles to achieve a synergist effect. The in vitro assays that were performed with the BT474 and HS5 cell lines showed that, when Fe3+ was adsorbed in PDA NPs at pH values close to which Fe(OH)3 begins to be formed, these nanoparticles had greater antitumor activity and selectivity despite having chelated a smaller amount of Fe3+. Otherwise, it was demonstrated that Fe3+ could be released in the late endo/lysosomes thanks to their acidic pH and their Ca2+ content, and that when Fe3+ was co-transported with doxorubicin, the therapeutic activity of PDA NPs was enhanced. Thus, reported PDA NPs loaded with both Fe3+ and doxorubicin may constitute a good approach to target breast tumors. 相似文献
4.
The surface texturing of ceramics is generally performed through acid-based etching and machining; however, laser texturing may be considered as a more precise, reproducible and eco-friendly process. Furthermore, laser ablation may be used to produce complex patterns on ceramic surfaces, thus offering new surface engineering opportunities. The studies so far conducted on this topic have mainly been application-driven, and since a wide variety of lasers have been used for surface texturing, it is difficult to have a comprehensive understanding of this technique applied to ceramics and ceramic composite materials. Laser texturing requires a great deal of knowledge of the material and the laser source parameters to optimise the process in order to obtain the expected results. It is therefore important to expand the research on the laser texturing of ceramics and CMCs in order to build a relevant amount of literature that can be used to identify the most appropriate parameters for each application. This review provides an overview of most of the technological aspects considered relevant for the laser surface texturing of ceramics and CMCs, and includes the fundamentals of laser-material interactions and a summary of the used equipment and parameters. Furthermore, most of the techniques related to the modifications of surface material induced by a laser are critically reviewed, and the new horizons that are opening up, in the context of the modification of surfaces to improve the performances of materials for several applications, are discussed. 相似文献
5.
Lucie Vitejnov Vclav Lika Arvind Kumar Jana Ke
kov Ondej Vy
ítal Jan Brha Jan Bene Yaroslav Kolinko Tereza Blassov Zbynk Tonar Michaela Brychtov Marie Karlíkov Jaroslav Racek Hynek Mírka Petr Hoek Daniel Lysk Milena Krlí
kov 《International journal of molecular sciences》2021,22(9)
In liver surgery, biliary obstruction can lead to secondary biliary cirrhosis, a life-threatening disease with liver transplantation as the only curative treatment option. Mesenchymal stromal cells (MSC) have been shown to improve liver function in both acute and chronic liver disease models. This study evaluated the effect of allogenic MSC transplantation in a large animal model of repeated biliary obstruction followed by partial hepatectomy. MSC transplantation supported the growth of regenerated liver tissue after 14 days (MSC group, n = 10: from 1087 ± 108 (0 h) to 1243 ± 92 mL (14 days); control group, n = 11: from 1080 ± 95 (0 h) to 1100 ± 105 mL (14 days), p = 0.016), with a lower volume fraction of hepatocytes in regenerated liver tissue compared to resected liver tissue (59.5 ± 10.2% vs. 70.2 ± 5.6%, p < 0.05). Volume fraction of connective tissue, blood vessels and bile vessels in regenerated liver tissue, serum levels of liver enzymes (AST, ALT, ALP and GGT) and liver metabolites (albumin, bilirubin, urea and creatinine), as well as plasma levels of IL-6, IL-8, TNF-α and TGF-β, were not affected by MSC transplantation. In our novel, large animal (pig) model of repeated biliary obstruction followed by partial hepatectomy, MSC transplantation promoted growth of liver tissue without any effect on liver function. This study underscores the importance of translating results between small and large animal models as well as the careful translation of results from animal model into human medicine. 相似文献
6.
Galin Ivanov Ertugrul Bilgucu Ivelina Ivanova Milena Dimitrova 《International Journal of Dairy Technology》2020,73(3):563-569
The present study aimed to investigate the effect of somatic cell count (SCC) of raw cow's milk on the volatile organic compound (VOC) profiles of yoghurt. Test yoghurt samples were produced from three batches of cow's milk with low, medium and high SCC, respectively. The VOCs were determined by gas chromatography–mass spectrometry (GC–MS) analysis. A lower diacetyl and acetoin content and a higher content of 2‐heptanone, and butanoic and hexanoic acids were established in the yoghurt samples from batches with high SCC of above 1 000 000 cells/cm3. The increased SCC of cow's milk had a negative effect on the volatile organic compound profiles of yoghurt. 相似文献
7.
Slobodan D. Dolić Dragana J. Jovanović Krisjanis Smits Biljana Babić Milena Marinović-Cincović Slavica Porobić Miroslav D. Dramićanin 《Ceramics International》2018,44(15):17953-17961
Monoclinic scheelite-type BiVO4 is currently considered as one of the most promising non-titania photocatalysts, wheras tetragonal zircon-type BiVO4 is still poorly understood. Herein, a new and simple synthetic approach was applied and nanostructured single-phase zircon-type BiVO4 was successfully prepared by a controllable ethylene-glycol colloidal route. In addition, nanostructured monoclinic scheelite-type BiVO4 powders were also fabricated through annealing of the as-prepared samples. A comparative study of the two BiVO4 polymorphs was conducted and it turned out that the novel synthetic approach had a significant impact on porosity and photocatalytic performance of zircon-structured BiVO4. All the prepared materials, as-prepared and annealed, were mesoporous, while measured values of specific surface area of some zircon-structured samples (~34?m2/g) were ~7 times higher than those reported thus far for this phase. Interestingly, for the first time, zircon-type BiVO4, previously considered to be a poor photocatalyst, exhibited a better overall performance in degradation of methyl orange compared to monoclinic scheelite-type BiVO4. Hence, it could be expected that the here-presented synthesis and observations will both arouse interest in scarcely studied tetragonal zircon-type BiVO4 and facilitate as well as speed up further research of its properties. 相似文献
8.
Milena Salvo Valentina Casalegno Manuela Suess Laura Gozzelino Christian Wilhelmi 《Ceramics International》2018,44(11):12081-12087
IR pulsed laser radiation in air was applied to Si3N4 and Invar to obtain reliable Si3N4/Si3N4 and Si3N4/Invar adhesive bonded components. The laser pre-treatment produced a homogeneous nanostructured oxide layer on the surfaces, which effectively increased the adhesion at the adhesive/adherends interface and led to cohesive failure in the joining material. The mechanical strength of Si3N4/ Si3N4 and Si3N4/Invar joined components was measured, with and without laser nanostructuring, before and after thermal cycling from room temperature to 50?K, and it resulted that the exposure to extremely low temperatures did not affect the mechanical integrity of the joints. It was also demonstrated that this laser pre-treatment did not alter the mechanical properties of the ceramic substrate. 相似文献
9.
Adamczyk-Cieślak Bogusława Koralnik Milena Kuziak Roman Majchrowicz Kamil Mizera Jarosław 《Metallurgical and Materials Transactions A》2021,52(12):5429-5442
Metallurgical and Materials Transactions A - This paper describes the development and characterisation of bainitic steel for rail applications based on carbide-free, low-alloy steel. The results... 相似文献
10.