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排序方式: 共有233条查询结果,搜索用时 109 毫秒
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Isabelle Duroux-Richard Jimena Cuenca Clara Ponsolles Alejandro Badilla Pi?eiro Fernando Gonzalez Christine Roubert Roser Areny Rosa Chea Jacqueline Pefaur Yves-Marie Pers Fernando E. Figueroa Christian Jorgensen Maroun Khoury Florence Apparailly 《International journal of molecular sciences》2015,16(8):16953-16965
MicroRNAs control the differentiation and function of B cells, which are considered key elements in the pathogenesis of systemic lupus erythematosus (SLE). However, a common micro(mi)RNA signature has not emerged since published data includes patients of variable ethnic background, type of disease, and organ involvement, as well as heterogeneous cell populations. Here, we aimed at identifying a miRNA signature of purified B cells from renal and non-renal severe SLE patients of Latin American background, a population known to express severe disease. Genome-wide miRNA expression analyses were performed on naive and memory B cells and revealed two categories of miRNA signatures. The first signature represents B cell subset-specific miRNAs deregulated in SLE: 11 and six miRNAs discriminating naive and memory B cells of SLE patients from healthy controls (HC), respectively. Whether the miRNA was up or down-regulated in memory B cells as compared with naive B cells in HC, this difference was abolished in SLE patients, and vice versa. The second signature identifies six miRNAs associated with specific pathologic features affecting renal outcome, providing a further understanding for SLE pathogenesis. Overall, the present work provided promising biomarkers in molecular diagnostics for disease severity as well as potential new targets for therapeutic intervention in SLE. 相似文献
3.
Jean Claude Assaf Andr El Khoury Ali Chokr Nicolas Louka Ali Atoui 《International Journal of Dairy Technology》2019,72(2):248-256
This study aimed to develop a new method for detoxification of milk from aflatoxin M1 (AFM1) by using Lactobacillus rhamnosus GG biofilm. After inoculation of milk contaminated with AFM1 into L. rhamnosus GG biofilm, the unbound AFM1 was extracted and quantified by HPLC. The stability of the formed AFM1/biofilm complex using different AFM1 contamination levels of milk was also studied. We found that the percentages of bound AFM1 by L. rhamnosus GG biofilm reached up to 60.74%. While no significant difference in milk proteins content was observed after AFM1 binding, some changes in total dry matter and fat content were noticed. 相似文献
4.
Initial moisture and pre-wetting method influence on the water absorption of recycled concrete aggregates (RCA) have been studied experimentally. For this purpose, RCA were pre-wetted by three methods: soaking under partial vacuum (simulating long term wetting), soaking under atmospheric pressure, and spraying (simulating short term wetting). The results show that the same initial amount of water in two samples of RCA do not lead to the same total amount of water absorbed by RCA during 5–120 min. The latter depends on the way they have been pre-wetted (either long term or short term). It is suggested that this phenomenon is related to the accessibility filled pores in the different pre-wetting methods. So, the pre-wetting history of RCA could change the amount of total water absorbed by the RCA up to 1%. When mixing and casting concrete are produced with RCA, the corresponding error in the determination of the effective water should have adverse effects on the fresh and hardened concrete characteristics. In this study real applications on mixtures of recycled concrete have been carried out, where the influence of initial moisture content and pre-wetting history of RCA on fresh recycled concrete properties (slump) have been investigated. 相似文献
5.
Oula El Korhani Doumit Zaouk Sophie Cerneaux Randa Khoury Antonio Khoury David Cornu 《Nanoscale research letters》2013,8(1):121
Hydrothermal carbonization (HTC) process of beer wastes (Almaza Brewery) yields a biochar and homogeneous carbon-based nanoparticles (NPs). The NPs have been used to prepare carbon membrane on commercial alumina support. Water filtration experiments evidenced the quasi-dense behavior of the membrane with no measurable water flux below an applied nitrogen pressure of 6 bar. Gas permeation tests were conducted and gave remarkable results, namely (1) the existence of a limit temperature of utilization of the membrane, which was below 100°C in our experimental conditions, (2) an evolution of the microstructure of the carbon membrane with the operating temperature that yielded to improved performances in gas separation, (3) the temperature-dependent gas permeance should follow a Knudsen diffusion mechanism, and (4) He permeance was increasing with the applied pressure, whereas N2 and CO2 permeances remained stable in the same conditions. These results yielded an enhancement of both the He/N2 and He/CO2 permselectivities with the applied pressure. These promising results made biomass-sourced HTC-processed carbon membranes encouraging candidates as ultralow-cost and sustainable membranes for gas separation applications. 相似文献
6.
Weidong Huang Raymes Khoury Tim Dawborn Bohan Huang Maolin Huang Xiaodi Huang 《中国科学:信息科学(英文版)》2013,56(5):1-15
Large wikis such as Wikipedia attract large numbers of editors continuously editing content. It is difficult to observe what editing activity goes on at any given moment, what editing patterns can be observed, and which are the currently active editors and articles. We introduce the design and implementation of an information visualization tool for data streams of recent changes in wikis that aims to address this difficulty. We also show examples of our visualizations from English Wikipedia, and present several patterns of editing activity that we have visually identified using our tool. We have evaluated our tool’s usability, accuracy and speed of task performance in comparison with Wikipedia’s recent changes page, and have obtained qualitative feedback from users on the pros and cons of our tool. We also present a review of the related literature. 相似文献
7.
Ian A. Wright Rhiannon Khoury Michelle M. Ryan Nakia Belmer Jason K. Reynolds 《Urban Water Journal》2018,15(1):61-67
This study investigated the effects of urban concrete materials, of different particle sizes, immersed in water through a laboratory-based experiment. Water was sourced from a high conservation-value wetland (Blue Mountains upland swamp). Prior to the experiment, wetland water was dilute (32.5 μS/cm), acidic (pH 5.3) and had detectable major ion concentrations of only sodium and chloride. Water was exposed to three treatments of different concrete fragment sizes (whole, crushed and fine). All treatments increased conductivity and pH and also resulted in modified ionic composition where calcium, potassium, hydroxide, carbonate and sulphate were recorded at much high levels. The extent and speed of water chemistry changes was linked to the particle size of the concrete. The results of this study support the hypothesis that concrete can be an environmentally hazardous material influencing water quality in urban catchments. 相似文献
8.
Hermier J.-P. Bramati A. Khoury A.Z. Josse V. Giacobino E. Schnitzer P. Michalzik R. Ebeling K.J. 《Quantum Electronics, IEEE Journal of》2001,37(1):87-91
We demonstrate the possibility of generating intensity squeezed light with free-running or injected multimode vertical-cavity surface-emitting laser. Sub-shot-noise operation results from very strong anticorrelations between the transverse modes. The influence of the active media diameter on the amount of squeezing is analyzed 相似文献
9.
Constant temperature creep of unsealed pure cement paste, gravel and lightweight concretes obtained under constant uniaxial compressive load are reported for temperatures between 140°C and 724°C. The work suggests that it is possible, within certain limits, to uncouple the time, stress and temperature functions of constant high temperature creep, which can be represented mathematically by a simple multiple of the three functions. The time functions of all three mixes were best represented by a power law with an exponent slightly influenced by temperature. It is suggested that the temperature function may not be sufficiently described by the Arrhenius relation during first heating. The temperature function indicated a sharp increase in creep for gravel concrete above 350°C caused by break-up of the aggregate. However, the sharp increase in creep for both lightweight concrete and cement paste above 600°C is seated in the cement paste and appears to be a function of “current” temperature. A rheological criterion therefore limits the structural usefulness of Portland cement concretes to temperatures below 600°C. Similarities in constant high temperature creep behaviour with other materials have been noted. 相似文献
10.
Khoury S. Kabalan K.Y. El-Hajj A. Rayes A. 《Antennas and Propagation Magazine, IEEE》1997,39(3):40-43
This paper presents the work carried out at the American University of Beirut on electromagnetic radiation and scattering, using the characteristic-modes theory. Several problems of various two-dimensional and three-dimensional geometrics have been considered: slots in a plane, slots in a conducting cylinder, a parallel plate-fed slot antenna, an aperture-fed waveguide, a rectangular aperture in a perfectly conducting plane, a cavity-backed aperture. The characteristic modes for each geometry were first computed, and the convergence of the solution was tested for all these problems. A combined characteristic-modes formulation, for the problem of electromagnetic coupling to conducting objects behind arbitrary apertures in a conducting plane, has been developed and used to solve many of these problems 相似文献