Herbivorous Caterpillars and the Green Leaf Volatile (GLV) Quandary

Several herbivorous caterpillars contain effectors in their oral secretions that alter the emission of green leaf volatiles (GLVs) produced by the plants upon which the caterpillars are feeding. These effectors include an isomerase, a fatty acid dehydratase (FHD), and a heat-stable hexenal trapping (HALT) molecule. GLVs serve as signaling compounds in plant-insect interactions and inter-and intra-plant communication. However, it is not known whether these GLV-altering effectors are common among herbivorous caterpillars, or the evolutionary context of these effectors in relation to GLV emission by host plants in response to feeding damage. Here, we examined the distribution and activity of the isomerase, FHD, and HALT effectors across 10 species spanning 7 lepidopteran families. Six of the 10 species possessed all three effectors in their oral secretions. Activity from the HALT and FHD effectors was observed in all examined caterpillar species, while activity from the isomerase effector varied in some species and was absent in others. There was no discernable pattern in effector activity based on evolutionary divergence, since individual species within a family did not possess similar mechanisms to alter GLV emission. These data, demonstrating the GLV-altering effectors acting at different steps in the GLV biosynthetic pathway and present in the examined caterpillar species at different combinations with different activities, highlight the importance of these effectors in changing the emission of these compounds during caterpillar herbivory. Understanding the prevalence and roles of GLV-altering effectors and GLV emission itself will open new research areas in the dynamics of plant-insect interactions.

     

Separation of He/N2/CH4 ternary mixtures by a triple-reflux pressure swing adsorption process

Conventional pressure swing adsorption (PSA) processes can only produce one high purity product in a single stage, whereas the state-of-art dual-reflux PSA (DR-PSA) can produce two high purity products simultaneously. However, multicomponent gas separation is often required in the industry, targeting at recovering several valued products at the same time. In this study, we propose a novel adsorption process, namely triple-reflux PSA (TR-PSA), to separate three components simultaneously. A middle product outlet and a middle reflux stream were introduced to the adsorption columns of a conventional DR-PSA process to separate ternary mixtures of nitrogen, methane, and helium. Nonisothermal dynamic models were built to investigate the impacts of operating parameters particularly the location of the middle reflux/product stream and the middle reflux flow rates. Results showed that the TR-PSA process successfully separated ternary mixtures obtaining three enriched products simultaneously in a single stage, yielding a separation performance comparable to that of the double-stage DR-PSA with significantly lower capital and energy cost.     

A New SiF–Dipropargyl Glycerol Scaffold as a Versatile Prosthetic Group to Design Dimeric Radioligands: Synthesis of the [18F]BMPPSiF Tracer to Image Serotonin Receptors

A novel SiX–dipropargyl glycerol scaffold (X: H, F, or ¹⁸F) was developed as a versatile prosthetic group that provides technical advantages for the preparation of dimeric radioligands based on silicon fluoride acceptor pre‐ or post‐labeling with fluorine‐18. Rapid conjugation with the prosthetic group takes place in microwave‐assisted click conjugation under mild conditions. Thus, a bivalent homodimeric SiX–dipropargyl glycerol derivatized radioligand, [¹⁸F]BMPPSiF, with enhanced affinity was developed by using click conjugation. High uptake of the radioligand was demonstrated in 5‐HT_1A receptor‐rich regions in the brain with positron emission tomography. Molecular docking studies (rigid protein–flexible ligand) of BMPPSiF and known antagonists (WAY‐100635, MPPF, and MefWAY) with monomeric, dimeric, and multimeric 5‐HT_1A receptor models were performed, with the highest G score obtained for docked BMPPSiF: ?6.766 as compared with all three antagonists on the monomeric model. Multimeric induced‐fit docking was also performed to visualize the comparable mode of binding under in vivo conditions, and a notably improved G score of ?8.455 was observed for BMPPSiF. These data directly correlate the high binding potential of BMPPSiF with the bivalent binding mode obtained in the biological studies. The present study warrants wide application of the SiX–dipropargyl glycerol prosthetic group in the development of ligands for imaging with enhanced affinity markers for specific targeting based on peptides, nucleosides, and lipids.     

Automated generation of program translation and verification tools using annotated grammars

Automatically generating program translators from source and target language specifications is a non-trivial problem. In this paper we focus on the problem of automating the process of building translators between operations languages, a family of DSLs used to program satellite operations procedures. We exploit their similarities to semi-automatically build transformation tools between these DSLs. The input to our method is a collection of annotated context-free grammars. To simplify the overall translation process even more, we also propose an intermediate representation common to all operations languages. Finally, we discuss how to enrich our annotated grammars model with more advanced semantic annotations to provide a verification system for the translation process. We validate our approach by semi-automatically deriving translators between some real world operations languages, using the prototype tool which we implemented for that purpose.     

Ester-functionalized poly(3-alkylthiophene) copolymers: Synthesis,physicochemical characterization and performance in bulk heterojunction organic solar cells

The introduction of functional moieties in the donor polymer (side chains) offers a potential pathway toward selective modification of the nanomorphology of conjugated polymer:fullerene active layer blends applied in bulk heterojunction organic photovoltaics, pursuing morphology control and solar cell stability. For this purpose, two types of poly(3-alkylthiophene) random copolymers, incorporating different amounts (10/30/50%) of ester-functionalized side chains, were efficiently synthesized using the Rieke method. The solar cell performance of the functionalized copolymers was evaluated and compared to the pristine P3HT:PCBM system. It was observed that the physicochemical and opto-electronic characteristics of the polythiophene donor material can be modified to a certain extent via copolymerization without (too much) jeopardizing the OPV efficiency, as far as the functionalized side chains are introduced in a moderate ratio (<30%) and that preference is given to side chains with a small molar volume. A range of complementary techniques – UV–Vis spectroscopy, (modulated temperature) differential scanning calorimetry, transmission electron microscopy and X-ray diffraction analysis – indicated that variations in polymer crystallinity, while maintaining a high level of regioregularity, are probably the main factor responsible for the observed differences.     

建立中国的规划文化辩证体系——荷兰经验的启发

引言 荷兰的国土面积约为41500 km2,其中约20%是水域.全国总人口数约为1600万,人口密度约为每平方公里484人,可以算是世界上人口密度较高的国家之一.荷兰有一个悠久的传统:人们坚信未来不是自然产生的,而是可以经由规划而创造的.     

Inelastic Plate Buckling

Current models to determine the local buckling stress of inelastic plates under in-plane loading are based on plastic deformation theory and semirational or empirical relationships. A successful J2 flow theory describing inelastic local buckling of initially perfect plates needs to avoid two well-known pitfalls known as the “inelastic column buckling paradox” and the “plastic buckling paradox.” While the former problem, which found its origin in 1895 in Engesser’s double modulus approach, was resolved by Shanley in the late 1940s, a convincing solution of the plastic buckling paradox has not yet been presented. This paper proposes a modification to the J2 flow theory which hinges on the determination of the shear stiffness from second-order considerations. A differential equation is derived which describes the incremental plate deformations at the inelastic local buckling load. The differential equation is studied for two cases of boundary conditions: a plate simply supported along four edges and a plate simply supported along three edges with one longitudinal edge free.     

The Multifaceted Role of Serotonin in Intestinal Homeostasis

The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with conserved production in prokaryotes and eukaryotes and a wide range of functions. In the gastrointestinal tract, enterochromaffin cells are the most important source for 5-HT production. Some intestinal bacterial species are also able to produce 5-HT. Besides its role as a neurotransmitter, 5-HT acts on immune cells to regulate their activation. Several lines of evidence indicate that intestinal 5-HT signaling is altered in patients with inflammatory bowel disease. In this review, we discuss the current knowledge on the production, secretion, and signaling of 5-HT in the intestine. We present an inventory of intestinal immune and epithelial cells that respond to 5-HT and describe the effects of these signaling processes on intestinal homeostasis. Further, we detail the mechanisms by which 5-HT could affect inflammatory bowel disease course and describe the effects of interventions that target intestinal 5-HT signaling.     

钢铁工业环境控制的现状及远景展望

刚刚迈进21世纪,往昔的国际或国内市场正在飞速发展为一个全球市场。环境保护也日益被人们看作是一个全球问题,即使在90年代早期Brundlandt委员会断言,人类有能力持续发展,当今和后代的需求都可以得到满足。钢铁工业愿意为持续发展作出自己的贡献。下面的报告将向我们展示环境保护在钢     

Evaluation-based closed-loop errors using principal component analysis and self-organisation map with an application to a pickling process

Closed-loop control is a basic technology in control engineering. Its role is to avoid the tracking error between set points and real variables. The evaluation of plant performance can be based on multivariate statistical process control connected to closed-loop errors behaviour. Due to its practicality, this approach has found many applications in several industries. This paper suggests a combined use of principal component analysis (PCA) and self-organisation map (SOM) algorithms to evaluate the process on the basis of closed-loop errors dynamic. Generally, it is possible to evaluate a product quality in the basis of the dynamic changes of the closed-loop control errors. In this paper, a new method based on the analysis of the control errors is proposed; it is carried out by a combined use of the PCA-SOM algorithm. Comparatively to the conventional PCA method, this new technique is characterised by the performant indexes that give an accurate evaluation of the process variability and its impact on the product quality. As shown in the different simulation results, the proposed approach gives a global evaluation and improves considerably the performance of computed indexes used for the evaluation of the controlled process.