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Sophie Bresch Björn Mieller Daniela Schönauer-Kamin Ralf Moos Timmy Reimann Fabien Giovannelli Torsten Rabe 《Journal of the American Ceramic Society》2021,104(2):917-927
Calcium cobaltite Ca3Co4O9, abbreviated Co349, is a promising thermoelectric material for high-temperature applications in air. Its anisotropic properties can be assigned to polycrystalline parts by texturing. Tape casting and pressure-assisted sintering (PAS) are a possible future way for a cost-effective mass-production of thermoelectric generators. This study examines the influence of pressure and dwell time during PAS at 900°C of tape-cast Co349 on texture and thermoelectric properties. Tape casting aligns lentoid Co349. PAS results in a textured Co349 microstructure with the thermoelectrically favorable ab-direction perpendicular to the pressing direction. By pressure variation during sintering, the microstructure of Co349 can be tailored either toward a maximum figure of merit as required for energy harvesting or toward a maximum power factor as required for energy harvesting. Moderate pressure of 2.5 MPa results in 25% porosity and a textured microstructure with a figure of merit of 0.13 at 700°C, two times higher than the dry-pressed, pressureless-sintered reference. A pressure of 7.5 MPa leads to 94% density and a high power factor of 326 µW/mK2 at 800°C, which is 11 times higher than the dry-pressed reference (30 MPa) from the same powder. 相似文献
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Daniela Frasca Maria Romero Alain Diaz Denisse Garcia Seth Thaller Bonnie B. Blomberg 《International journal of molecular sciences》2021,22(4)
Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence-associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper-metabolic profile necessary to support the increased immune activation of AT-derived B cells as compared to blood-derived B cells. This hyper-metabolic profile is needed for the secretion of the pro-inflammatory mediators (cytokines, chemokines, micro-RNAs) that fuel local and systemic inflammation. 相似文献
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Dr. Daniela Carbone Dr. Barbara Parrino Dr. Stella Cascioferro Camilla Pecoraro Prof. Elisa Giovannetti Dr. Veronica Di Sarno Dr. Simona Musella Dr. Giulia Auriemma Prof. Girolamo Cirrincione Prof. Patrizia Diana 《ChemMedChem》2021,16(3):537-554
A new series of topsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,2,4-oxadiazole moiety, was efficiently synthesized. All derivatives were pre-screened for antiproliferative activity against the National Cancer Institute (NCI-60) cell lines panel. The five most potent compounds were further investigated in various pancreatic ductal adenocarcinoma (PDAC) cell lines, including SUIT-2, Capan-1, and Panc-1 cells, eliciting EC50 values in the micromolar and sub-micromolar range, associated with significant reduction of cell migration. These remarkable results might be explained by the effects of these new topsentin analogues on epithelial-to-mesenchymal transition markers, including SNAIL-1/2 and metalloproteinase-9. Moreover, flow cytometric analysis after Annexin V-FITC and propidium iodide staining demonstrated that these derivatives enhanced apoptosis of PDAC cells. Keeping with these data, the PathScan intracellular signaling and ELISA array revealed cleavage of caspase-3 and PARP and a significant inhibition of GSK3β phosphorylation, suggesting this kinase as a potential downstream target of our novel compounds. This was further supported by a specific assay for the evaluation of GSK3β activity, showing IC50 values for the most active compounds against this enzyme in the micromolar range. 相似文献
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Domingue Catherine Lemieux Jean-Michel Grenon Martin Molson John Therrien René Lajoie Pierre-Luc Blessent Daniela 《Mine Water and the Environment》2019,38(3):497-506
Mine Water and the Environment - Water inflows through fracture networks are a major economic and safety issue in underground mines. Although pre-grouting of pilot holes during mine development... 相似文献