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排序方式: 共有131条查询结果,搜索用时 15 毫秒
1.
Manuel Gentiluomo Alice Luddi Annapaola Cingolani Marco Fornili Laura Governini Ersilia Lucenteforte Laura Baglietto Paola Piomboni Daniele Campa 《International journal of molecular sciences》2021,22(8)
Over the past decade, telomeres have attracted increasing attention due to the role they play in human fertility. However, conflicting results have been reported on the possible association between sperm telomere length (STL) and leukocyte telomere length (LTL) and the quality of the sperm parameters. The aim of this study was to run a comprehensive study to investigate the role of STL and LTL in male spermatogenesis and infertility. Moreover, the association between the sperm parameters and 11 candidate single nucleotide polymorphisms (SNPs), identified in the literature for their association with telomere length (TL), was investigated. We observed no associations between sperm parameters and STL nor LTL. For the individual SNPs, we observed five statistically significant associations with sperm parameters: considering a p < 0.05. Namely, ACYP2˗rs11125529 and decreased sperm motility (p = 0.03); PXK˗rs6772228 with a lower sperm count (p = 0.02); NAF1˗rs7675998 with increased probability of having abnormal acrosomes (p = 0.03) and abnormal flagellum (p = 0.04); ZNF208˗rs8105767 and reduction of sperms with normal heads (p = 0.009). This study suggests a moderate involvement of telomere length in male fertility; however, in our analyses four SNPs were weakly associated with sperm variables, suggesting the SNPs to be pleiotropic and involved in other regulatory mechanisms independent of telomere homeostasis, but involved in the spermatogenic process. 相似文献
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Inside Cover: Looking for Efficient G‐Quadruplex Ligands: Evidence for Selective Stabilizing Properties and Telomere Damage by Drug‐Like Molecules (ChemMedChem 4/2015) 下载免费PDF全文
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Elena Samoylova William Dallari Marco Allione Francesca Pignatelli Lara Marini Roberto Cingolani Alberto Diaspro Athanassia Athanassiou 《Materials Science and Engineering: B》2013,178(10):730-735
Fatigue resistance of the photochromic diarylethene molecules 1,2-bis[2-methylbenzo[b]thyophen-3-yl]-3,3,4,4,5,5-hexafluoro-1-cyclopentene embedded in three different acrylic polymers is studied upon multiple coloration–decoloration cycles. The resistance to photofatigue is found to be different in the three polymeric materials when one-photon excitation was used for the reversible photoconversion experiment. In particular, the photochromic molecules lose their photoisomerization ability faster if they are embedded in poly(methyl methacrylate) (PMMA) with respect to poly(ethyl methacrylate-co-methyl acrylate) (PEMMA) and poly(ethyl methacrylate) (PEMA). We propose several explanations based on the physico-chemical properties of the matrix and of the photochromic molecules. In the case of two-photon excitation, which is necessary for 3D optical writing, the fatigue resistance is found to be poorer than in the one-photon case. The accelerated photodegradation can be assigned to the non-linear nature of interaction between the polymeric composite material and light. 相似文献
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Wide bandgap nitride semiconductors have recently attracted a great level of attention owing to their direct bandgaps in the
visible to ultraviolet regions of the spectrum as emitters and detectors. Moreover, this material system with its favorable
hetero-junctions and transport properties began to produce very respectable power levels in microwave amplifiers. If and when
the breakdown fields achieved experimentally approach the predicted values, this material system would also be very attractive
for power switching devices. In addition to the premature breakdown, high concentration of defects, and inhomogeneities, a
number of scientific challenges remain including a clear experimental investigation of polarization effects. In this paper,
following a succinct review of the progress that has been made, spontaneous and piezoelectric polarization effects and their
impact on sample device-like hetero-structures will be treated.
Received: 5 April 1999 / Reviewed and accepted: 19 April 1999 相似文献
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Frascerra V. Calabi F. Maruccio G. Pompa P.P. Cingolani R. Rinaldi R. 《Nanotechnology, IEEE Transactions on》2005,4(5):637-640
Electron transfer through the redox metalloprotein azurin immobilized on Au (111) by its disulphide bridge is studied by scanning tunneling microscopy (STM) in buffer solution and (for the first time) in air. STM analysis gives evidences of a stable and robust binding of the molecules in both cases. Bright spots, associated with azurin molecules, are clearly visible in STM images. The image contrast of adsorbed azurin is highly affected by the bias potential with proteins visible only for some well-defined voltage values. This experimental demonstration of the possibility to induce tunneling through azurin in air could disclose very interesting perspectives for the development of protein-based hybrid nanodevices operating in nonliquid environments. 相似文献
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