Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway

Obesity and hyperlipidemia are major risk factors for developing vascular diseases. Bee bread (BB) has been reported to exhibit some biological actions, including anti-obesity and anti-hyperlipidemic. This study aims to investigate whether bee bread can ameliorate vascular inflammation and impaired vasorelaxation activity through eNOS/NO/cGMP pathway in obese rats. Forty male Sprague-Dawley rats were randomly divided into four groups (n = 10/group), namely: control (normal group), obese rats (OB group), obese rats treated with bee bread (0.5 g/kg/day, OB/BB group) and obese rats treated with orlistat (10 mg/kg/day, OB/OR group). The latter three groups were given a high-fat diet (HFD) for 6 weeks to induced obesity before being administered with their respective treatments for another 6 weeks. After 12 weeks of the total experimental period, rats in the OB group demonstrated significantly higher Lee obesity index, lipid profile (total cholesterol, triglyceride, low-density lipoprotein), aortic proinflammatory markers (tumor necrosis factor-α, nuclear factor-κβ), aortic structural damage and impairment in vasorelaxation response to acetylcholine (ACh). Bee bread significantly ameliorated the obesity-induced vascular damage manifested by improvements in the lipid profile, aortic inflammatory markers, and the impaired vasorelaxation activity by significantly enhancing nitric oxide release, promoting endothelial nitric oxide synthase (eNOS) and cyclic guanosine monophosphate (cGMP) immunoexpression. These findings suggest that the administration of bee bread ameliorates the impaired vasorelaxation response to ACh by improving eNOS/NO/cGMP-signaling pathway in obese rats, suggesting its vascular therapeutic role.     

Al2O3/Yttria‐Stabilized Zirconia Hollow‐Fiber Membrane Incorporated with Iron Oxide for Pb(II) Removal

Removal by absorptive ceramic membranes can simultaneously absorb and separate metal ions from water. Alumina/yttria‐stabilized zirconia (Al₂O₃/YSZ) hollow‐fiber membranes, fabricated using phase inversion and sintering process, were deposited with iron oxide by an in‐situ hydrothermal process. The results showed that α‐Fe₂O₃ was produced and incorporated across the membranes. A reduction in flux was recorded with the deposition of α‐Fe₂O_3. However, it improved the adsorption capacity for heavy metal adsorption. The adsorption‐separation test demonstrated that the optimized membrane is able to completely remove Pb(II) ions after two hours.     

The availability of daylight from tropical skies—a case study of Malaysia

In Malaysia, no long-term daylight data are measured. It was only recently that the need to measure the availability of daylight became urgent when the importance of daylighting in buildings was rediscovered. The hourly daylight availability has been simulated for the Malaysian sky using daylight modelling techniques based on empirical and measured solar irradiation and cloud cover data. This paper presents the techniques involved in producing exterior illuminance data. These data were then compared with measured illuminance at Shah Alam and Bangi, Malaysia. The global illuminance levels are generally high, with values exceeding 80,000 lux at noon during the months when solar irradiation is highest. Even during the months when the ground receives less solar irradiation, the peak illuminance can reach 60,000 lux. Applications and uses of such data are in daylighting design, both for visual and thermal comfort, task illuminance and energy-conscious design of buildings. Recommendations are made at the end of the paper on the various climatic data that are required to be measured for overall daylighting design applications.     

Transition to turbulence in rotating-disk boundary layers—convective and absolute instabilities

This work is an experimental study of mechanisms for transition to turbulence in the boundary layer on a rotating disk. In one case, the focus was on a triad resonance between pairs of traveling cross-flow modes and a stationary cross-flow mode. The other was on the temporal growth of traveling modes through a linear absolute instability mechanism first discovered by Lingwood (1995, J Fluid Mech 314:373–405). Both research directions made use of methods for introducing controlled initial disturbances. One used a distributed array of ink dots placed on the disk surface to enhance a narrow band of azimuthal and radial wave numbers of both stationary and traveling modes. The size of the dots was small so that the disturbances they produce were linear. Another approach introduced temporal disturbances by a short-duration air pulse from a hypodermic tube located above the disk and outside the boundary layer. Hot-wire sensors primarily sensitive to the azimuthal velocity component, were positioned at different spatial (r,θ) locations on the disk to document the growth of disturbances. Spatial correlation measurements were used with two simultaneous sensors to obtain wavenumber vectors. Cross-bicoherence was used to identify three-frequency phase locking. Ensemble averages conditioned on the air pulses revealed wave packets that evolved in time and space. The space–time evolution of the leading and trailing edges of the wave packets were followed past the critical radius for the absolute instability, r _{c A} . With documented linear amplitudes, the spreading of the disturbance wave packets did not continue to grow in time as r _{c A} was approached. Rather, the spreading of the trailing edge of the wave packet decelerated and asymptotically approached a constant. This result supports the linear DNS simulations of Davies and Carpenter (2003, J Fluid Mech 486:287–329) who concluded that the absolute instability mechanism does not result in a global mode, and that linear-disturbance wave packets are dominated by the convective instability. In contrast, wave-number matching between traveling cross-flow modes confirmed a triad resonance that lead to the growth of a low azimuthal number (n = 4) stationary mode. At transition, this mode had the largest amplitude. Signs of this mechanism can be found in past flow visualization of transition to turbulence in rotating disk flows.     

Electrocoagulation technique in enhancing COD and suspended solids removal to improve wastewater quality.

This paper presents a preliminary study for the removal of COD and suspended solids in wastewater treatment by combining magnetic field and electrocoagulation (EC) technology. The experiments were carried out using batch apparatus and setup in the static method. Batch experiments with two monopolar iron (Fe) plate anodes and cathodes were employed as electrodes. Wastewater samples were prepared from milk powder with an initial COD of 1,140 mgL(-1) and suspended solids of 1,400 mgL(-1) and acidic conditions were employed (pH approximately 3). DC current was varied from 0.5-0.8 A and operating times were between 30 and 50 min. The results show that the effluent wastewater was very clear (turbidity approximately 9 NTU) and its quality exceeded the direct discharge standard. The suspended solids and COD removal efficiencies were as high as 30.6 and 75.5%, respectively. In addition, the experimental results also show that the electrocoagulation could neutralise the pH of wastewater.     

Shortcoming, problems and analytical comparison for flooding-based search techniques in unstructured P2P networks

Peer-to-Peer networks attracted a significant amount of interest because of their capacity for resource sharing and content distribution. Content distribution applications allow personal computers to function in a coordinated manner as a distributed storage medium by contributing, searching, and obtaining digital content. Searching in unstructured P2P networks is an important problem, which has received considerable research attention. Acceptable searching techniques must provide large coverage rate, low traffic load, and optimum latency. This paper reviews flooding-based search techniques in unstructured P2P networks. It then analytically compares their coverage rate, and traffic overloads. Our simulation experiments have validated analytical results.     

Mental imagery classification using one-dimensional convolutional neural network for target selection in single-channel BCI-controlled mobile robot

Neural Computing and Applications - This paper introduces the use of the one-dimensional convolutional neural network (1D-CNN) for end-to-end EEG decoding with application towards a BCI system with...     

Probing the Structural and Antimicrobial Study on a Sol–Gel Derived Velosef-Loaded Bioactive Calcium Magneso-Silicate Xerogel

Silicon - The nature of the opening silicate- based surface affects the chemical interaction, spectroscopic and antimicrobial efficiency. The aim of this approach was to evaluate the spectroscopic...     

Modern Template Design and Biological Evaluation of Cephradine-loaded Magnesium Calcium Silicate Nanocomposites as an Inhibitor for Nosocomial Bacteria in Biomedical Applications

Silicon - Magnesium calcium silicate nanostructures (MCSNS) loaded with (0.0, 0.6, 0.9, and 1.2 wt%) of Cephradine-drug consisting of mesoporous particles were functionally prepared by sol-gel...     

Synthesis and Characterization of Nano-Composite Alumina–Titania Ceramic Membrane for Gas Separation

A ceramic composite membrane was prepared using a commercial titania ceramic membrane coated by alumina oxide via a sol–gel technique where polyvinyl alcohol (PVA) was used as a binder. The characteristic of the membrane was analyzed in terms of the effect of PVA concentration and sintering temperature on viscosity, pore size, density, porosity and surface area of the membrane. Two vol% of PVA solution containing 4 g of PVA in 100 mL of water was adequate to achieve an appropriate porosity level to avoid cracks on the gel layer. Sol viscosity and pore size of the membrane essentially increased when the PVA concentration was increased. The density of the membrane increased as the sintering temperature increased. The porosity level however, decreased when the temperature was increased. The composite membrane was further characterized in terms of permeability of pure gas at low-temperature region (301 K) where an experimental platform has been developed to perform the permeability studies.