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1.
Katia Varani Fabrizio Vincenzi Silvia Pasquini Irene Blo Simona Salati Matteo Cadossi Monica De Mattei 《International journal of molecular sciences》2021,22(2)
Mesenchymal stem cells (MSCs) are the main cell players in tissue repair and thanks to their self-renewal and multi-lineage differentiation capabilities, they gained significant attention as cell source for tissue engineering (TE) approaches aimed at restoring bone and cartilage defects. Despite significant progress, their therapeutic application remains debated: the TE construct often fails to completely restore the biomechanical properties of the native tissue, leading to poor clinical outcomes in the long term. Pulsed electromagnetic fields (PEMFs) are currently used as a safe and non-invasive treatment to enhance bone healing and to provide joint protection. PEMFs enhance both osteogenic and chondrogenic differentiation of MSCs. Here, we provide extensive review of the signaling pathways modulated by PEMFs during MSCs osteogenic and chondrogenic differentiation. Particular attention has been given to the PEMF-mediated activation of the adenosine signaling and their regulation of the inflammatory response as key player in TE approaches. Overall, the application of PEMFs in tissue repair is foreseen: (1) in vitro: to improve the functional and mechanical properties of the engineered construct; (2) in vivo: (i) to favor graft integration, (ii) to control the local inflammatory response, and (iii) to foster tissue repair from both implanted and resident MSCs cells. 相似文献
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Carmen J. Pastor-Maldonado Juan M. Surez-Rivero Suleva Povea-Cabello Mnica lvarez-Crdoba Irene Villaln-García Manuel Munuera-Cabeza Alejandra Surez-Carrillo Marta Talavern-Rey Jos A. Snchez-Alczar 《International journal of molecular sciences》2020,21(22)
The aim of this review is to shed light over the most recent advances in Coenzyme Q10 (CoQ10) applications as well as to provide detailed information about the functions of this versatile molecule, which have proven to be of great interest in the medical field. Traditionally, CoQ10 clinical use was based on its antioxidant properties; however, a wide range of highly interesting alternative functions have recently been discovered. In this line, CoQ10 has shown pain-alleviating properties in fibromyalgia patients, a membrane-stabilizing function, immune system enhancing ability, or a fundamental role for insulin sensitivity, apart from potentially beneficial properties for familial hypercholesterolemia patients. In brief, it shows a remarkable amount of functions in addition to those yet to be discovered. Despite its multiple therapeutic applications, CoQ10 is not commonly prescribed as a drug because of its low oral bioavailability, which compromises its efficacy. Hence, several formulations have been developed to face such inconvenience. These were initially designed as lipid nanoparticles for CoQ10 encapsulation and distribution through biological membranes and eventually evolved towards chemical modifications of the molecule to decrease its hydrophobicity. Some of the most promising formulations will also be discussed in this review. 相似文献
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Biocatalysis offers a broad spectrum of possible ecological and economic advantages over conventional chemical catalysis processes, e.g., lower energy consumption and high enantio selectivity. The focus of this work is on gas-liquid reactions. These are of great importance in the chemical and biochemical industry and subject of current research since they are often limited by mass transfer or show low selectivity. Different suitable biocatalytically gas-liquid reaction systems were tested in capillary reactor designs in order to obtain information about the interaction between reaction and fluid mechanics. Furthermore, an optical measuring method was established. The experiments were performed in batch mode in a glass beaker with a flow cuvette for UV/Vis measurement of product concentration. 相似文献
7.
Norris Fran H.; Murphy Arthur D.; Baker Charlene K.; Perilla Julia L.; Rodriguez Francisco Gutiérrez; Rodriguez José de Jesús Gutiérrez 《Canadian Metallurgical Quarterly》2003,112(4):646
Prevalence rates of trauma and posttraumatic stress disorder (PTSD) were estimated from a probability sample of 2,509 adults from 4 cities in Mexico. PTSD was assessed according to Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 1994) criteria using the Composite International Diagnostic Interview (CIDI; WHO, 1997). Lifetime prevalence of exposure and PTSD were 76% and 11.2%, respectively. Risk for PTSD was highest in Oaxaca (the poorest city), persons of lower socioeconomic status, and women. Conditional risk for PTSD was highest following sexual violence, but nonsexual violence and traumatic bereavement had greater overall impact because of their frequency. Of lifetime cases, 62% became chronic; only 42% received medical or professional care. The research demonstrates the importance of expanding the epidemiologic research base on trauma to include developing countries around the world. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Examined the theory that chronic migraine headaches can lead to permanent changes in brain function in 71 female college students. Ss were 20 classic migraineurs, 27 common migraineurs, and 24 controls. No significant group differences were found on the Halstead Reitan Neuropsychological Test Battery and additional memory tests. Classic migraineurs had significantly higher scores than common migraineurs on the Hysteria and Paranoia scales of the Minnesota Multiphasic Personality Inventory (MMPI) and significantly higher scores than the controls on Hypochondriasis and Hysteria scales. Explanations for the lack of cognitive deficits in this group are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Emergency department status boards: user-evolved artefacts for inter- and intra-group coordination 总被引:1,自引:1,他引:0
Robert L. Wears Shawna J. Perry Stephanie Wilson Julia Galliers James Fone 《Cognition, Technology & Work》2007,9(3):163-170
Large, easily viewed status boards are commonly used in some healthcare settings such as emergency departments, operating
theaters, intensive care units, and inpatient wards. Because these artefacts were developed by front-line users, and have
little to no supervisory or regulatory control, they offer valuable insights into the theories of work and hazard held by
those users. Although the status boards case were locally developed over many years for within-group coordination, they have
also become useful for between-group coordination across organizational boundaries. In this paper, we compare and contrast
the use of such status boards in two disparate settings: a US emergency department, and a UK pediatric ward, and note striking
similarities in their form and usage, despite the large differences in setting. 相似文献
10.
Annie I. Anton Julia B. Eart Matthew W. Vail Neha Jain Carrie M. Gheen Jack M. Frink 《Security & Privacy, IEEE》2007,5(1):45-52
Healthcare institutions typically post their privacy practices online as privacy policy documents. We conducted a longitudinal study that examines the effects of HIPAA's enactment on a collection of privacy policy documents for a fixed set of organizations over a four-year period. We present our analysis of 24 healthcare privacy policy documents from nine healthcare Web sites, analyzed using goal mining, a content-analysis method that supports extraction of useful information about institutions' privacy practices from documents. We compare our results to our pre-HIPAA study of these same institutions' online privacy practices and evaluate their evolution in the presence of privacy laws 相似文献