Reducing sample size needed for cox-proportional hazards model analysis using more efficient sampling method

Abstract

In general, survival data are time-to-event data, such as time to death, time to appearance of a tumor, or time to recurrence of a disease. Models for survival data have frequently been based on the proportional hazards model, proposed by Cox. The Cox model has intensive application in the field of social, medical, behavioral and public health sciences. In this paper we propose a more efficient sampling method of recruiting subjects for survival analysis. We propose using a Moving Extreme Ranked Set Sampling (MERSS) scheme with ranking based on an easy-to-evaluate baseline auxiliary variable known to be associated with survival time. This paper demonstrates that this approach provides a more powerful testing procedure as well as a more efficient estimate of hazard ratio than that based on simple random sampling (SRS). Theoretical derivation and simulation studies are provided. The Iowa 65+ Rural study data are used to illustrate the methods developed in this paper.     

Role of Random Capacity Risk and the Retailer in Decentralized Supply Chains with Competing Suppliers

This research considers a supply chain under the following conditions: (i) two heterogeneous suppliers are in competition, (ii) supply capacity is random and pricing is endogenous, (iii) consumer demand, with and without an intermediate retailer, is price dependent. Specifically, we examine how uncertainty in supply capacity affects optimal ordering and pricing decisions, supplier and retailer profits, and the incentives to reduce such uncertainty. When two suppliers sell through a monopolistic retailer, supply uncertainty not only affects the retailer's diversification strategy for replenishment, but also changes the suppliers’ wholesale price competition and the incentive for reducing capacity uncertainty. In this dual‐sourcing model, we show that the benefit of reducing capacity uncertainty depends on the cost heterogeneity between the suppliers. In addition, we show that a supplier does not necessarily benefit from capacity variability reduction. We contrast this incentive misalignment with findings from the single‐supplier case and a supplier‐duopoly case where both suppliers sell directly to market without the monopolistic retailer. In the latter single‐supplier and duopoly cases, we prove that the unreliable supplier always benefits from reducing capacity variability. These results highlight the role of the retailer's diversification strategy in distorting a supplier's incentive for reducing capacity uncertainty under supplier price competition.     

Estimates for cell counts and common odds ratio in three-way contingency tables by homogeneous log-linear models with missing data

Missing observations often occur in cross-classified data collected during observational, clinical, and public health studies. Inappropriate treatment of missing data can reduce statistical power and give biased results. This work extends the Baker, Rosenberger and Dersimonian modeling approach to compute maximum likelihood estimates for cell counts in three-way tables with missing data, and studies the association between two dichotomous variables while controlling for a third variable in \( 2\times 2 \times K \) tables. This approach is applied to the Behavioral Risk Factor Surveillance System data. Simulation studies are used to investigate the efficiency of estimation of the common odds ratio.     

On quantiles estimation based on different stratified sampling with optimal allocation

This work considers the problem of estimating a quantile function based on different stratified sampling mechanism. First, we develop an estimate for population quantiles based on stratified simple random sampling (SSRS) and extend the discussion for stratified ranked set sampling (SRSS). Furthermore, the asymptotic behavior of the proposed estimators are presented. In addition, we derive an analytical expression for the optimal allocation under both sampling schemes. Simulation studies are designed to examine the performance of the proposed estimators under varying distributional assumptions. The efficiency of the proposed estimates is further illustrated by analyzing a real data set from CHNS.     

Managing Disruptions in Decentralized Supply Chains with Endogenous Supply Process Reliability

Supply disruptions are all too common in supply chains. To mitigate delivery risk, buyers may either source from multiple suppliers or offer incentives to their preferred supplier to improve its process reliability. These incentives can be either direct (investment subsidy) or indirect (inflated order quantity). In this study, we present a series of models to highlight buyers’ and suppliers’ optimal parameter choices. Our base‐case model has deterministic buyer demand and two possibilities for the supplier yield outcomes: all‐or‐nothing supply or partial disruption. For the all‐or‐nothing model, we show that the buyer prefers to only use the subsidy option, which obviates the need to inflate order quantity. However, in the partial disruption model, both incentives—subsidy and order inflation—may be used at the same time. Although single sourcing provides greater indirect incentive to the selected supplier because that avoids order splitting, we show that the buyer may prefer the diversification strategy under certain circumstances. We also quantify the amount by which the wholesale price needs to be discounted (if at all) to ensure that dual sourcing strategy dominates sole sourcing. Finally, we extend the model to the case of stochastic demand. Structural properties of ordering/subsidy decisions are derived for the all‐or‐nothing model, and in contrast to the deterministic demand case, we establish that the buyer may increase use of subsidy and order quantity at the same time.     

On kernel density estimation based on different stratified sampling with optimal allocation

Kernel density estimation is probably the most widely used non parametric statistical method for estimating probability densities. In this paper, we investigate the performance of kernel density estimator based on stratified simple and ranked set sampling. Some asymptotic properties of kernel estimator are established under both sampling schemes. Simulation studies are designed to examine the performance of the proposed estimators under varying distributional assumptions. These findings are also illustrated with the help of a dataset on bilirubin levels in babies in a neonatal intensive care unit.     

Increased Fisher’s information for parameters of association in count regression via extreme ranks

The article details a sampling scheme which can lead to a reduction in sample size and cost in clinical and epidemiological studies of association between a count outcome and risk factor. We show that inference in two common generalized linear models for count data, Poisson and negative binomial regression, is improved by using a ranked auxiliary covariate, which guides the sampling procedure. This type of sampling has typically been used to improve inference on a population mean. The novelty of the current work is its extension to log-linear models and derivations showing that the sampling technique results in an increase in information as compared to simple random sampling. Specifically, we show that under the proposed sampling strategy the maximum likelihood estimate of the risk factor’s coefficient is improved through an increase in the Fisher’s information. A simulation study is performed to compare the mean squared error, bias, variance, and power of the sampling routine with simple random sampling under various data-generating scenarios. We also illustrate the merits of the sampling scheme on a real data set from a clinical setting of males with chronic obstructive pulmonary disease. Empirical results from the simulation study and data analysis coincide with the theoretical derivations, suggesting that a significant reduction in sample size, and hence study cost, can be realized while achieving the same precision as a simple random sample.     

A simpler approach for mediation analysis for dichotomous mediators in logistic regression

Mediation is a hypothesized causal chain among three variables. Mediation analysis for continuous response variables is well developed in the literature, and it can be shown that the indirect effect is equal to the total effect minus the direct effect. However, mediation analysis for categorical responses is still not fully developed. The purpose of this article is to propose a simpler method of analysing the mediation effect among three variables when the dependent and mediator variables are both dichotomous. We propose using the latent variable technique which in turn will adjust for the necessary condition that indirect effect is equal to the total effect minus the direct effect. An intensive simulation study is conducted to compare the proposed method with other methods in the literature. Our theoretical derivation and simulation study show that the proposed approach is simpler to use and at least as good as other approaches provided in the literature. We illustrate our approach to test for the potential mediators on the relationship between depression and obesity among children and adolescents compared to the method in Winship and Mare using National children health survey data 2011–2012.