Effects of purposeful soccer heading on circulating small extracellular vesicle concentration and cargo

BackgroundConsidering the potential cumulative effects of repetitive head impact (HI) exposure, we need sensitive biomarkers to track short- and long-term effects. Circulating small extracellular vesicles (sEVs) (<200 nm) traffic biological molecules throughout the body and may have diagnostic value as biomarkers for disease. The purpose of this study was to identify the microRNA (miRNA) profile in circulating sEVs derived from human plasma following repetitive HI exposure.MethodsHealthy adult (aged 18–35 years) soccer players were randomly assigned to one of 3 groups: the HI group performed 10 standing headers, the leg impact group performed 10 soccer ball trapping maneuvers over 10 min, and the control group did not participate in any soccer drills. Plasma was collected before testing and 24 h afterward, and sEVs were isolated and characterized via nanoparticle tracking analysis. Next-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs, and candidate microRNAs were analyzed via quantitative polymerase chain reaction. In silico target prediction was performed using TargetScan (Version 7.0; targetscan.org) and miRWalk (http://mirwalk.umm.uni-heidelberg.de/) programs, and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney (HEK) 293T/17 cells.ResultsPlasma sEV concentration and size were not affected across time and group following repetitive HI exposure. After 24 h, the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p, miR-423-5p, and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p, miR-144-5p, miR-221-5p, and miR-22-3p. Analysis of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA levels. To our knowledge, miR-7844-5p is a previously unknown miRNA. We identified 8 miR-7844-5p mRNA targets: protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B), LIM and senescent cell antigen-like domains 1 (LIMS1), autophagy-related 12 (ATG12), microtubule-associated protein 1 light chain 3 beta (MAP1LC3B), integrin subunit alpha-1 (ITGA1), mitogen-activated protein kinase 1 (MAPK1), glycogen synthase kinase 3β (GSK3β), and mitogen-activated protein kinase 8 (MAPK8).ConclusionCollectively, these data indicate repetitive HI exposure alters plasma sEV miRNA content, but not sEV size or number. Furthermore, for the first time we demonstrate that previously unknown miR-7844-5p targets mRNAs known to be involved in mitochondrial apoptosis, autophagy regulation, mood disorders, and neurodegenerative disease.     

Gender differences in adolescents’ choice of heroes and admired adults in five countries

Seven hundred and sixty-eight adolescents from five countries and regions (USA, Spain, Hong Kong, Qatar, and Malaysia), aged 13–19 (M?=?15.78; SD?=?1.28) years, responded to a questionnaire designed to determine who was their most admired famous adult or hero. Male heroes clearly outnumbered admired females (73.3% vs. 26.7%). There was a pattern of same-sex choices, but it was more likely for girls to choose male heroes than for boys to choose females. Over half of the admired adults were athletes, and movie, television, and music stars. Regarding the personally known adults, there was a more balanced choice of males and females, with parents as the most frequent choice. Results suggest that society continues to fail in providing an adequate supply of female role models.     

Unsettling a sacred relationship: The mother–daughter–man romantic love triangle in telenovelas

Telenovelas are serialized melodramatic love stories whose happy endings are postponed by intrigues and obstacles. The main source of these impediments is also the basic building block of every telenovela: the love triangle. Because they unsettle the mother–daughter relation, mother–daughter–man triangles can be risky. But they can be successful too. This study examines the production, representation, consumption, and social regulation of the mother–daughter–man love triangle in three telenovelas: Ciudad Bendita (2006, Venevisión-Venezuela), Doña Bárbara (2008, Telemundo-USA), and La Mujer Perfecta (2010, Venevisión-Venezuela). Located under the umbrella of cultural studies, the study uses a multimethod approach that includes textual and ethnographic methods. The analysis underscores the writing and production challenges of this particular love triangle, considers the fit, or lack thereof, of the mother–daughter dyad with the virgin/whore dichotomy present in the majority of telenovelas, and fleshes out the nuances of audience reception of this type of triangle.     

International football tournaments,emotional entrainment and the reproduction of symbolic boundaries. A case study in Germany

Understanding the social consequences of major soccer events is important for social science researchers and policy-makers alike. On the one hand, socially integrative effects are ascribed to these events. On the other hand, they are suspected of increasing the devaluation of minorities and disadvantaged groups. Sociological theories in a Durkheimian tradition suggest that the emotional entrainment that goes along with football-related rituals might play a role. We thus investigated the effects of the World Cup 2010 on the derogation of minorities and disadvantaged groups in Germany and hypothesized that the emotional entrainment is a predictor of changes in derogation. Results of our naturalistic study show significant increases in derogative attitudes after the World Cup. Contrary to our expectations, emotional entrainment is not associated with this increase. We discuss possible alternative explanations, in particular the influence of public discourse.     

Sighting horizons of teaching in higher education

This conceptual paper tackles the matter of teaching in higher education and proposes a concept of ‘horizons of teaching’. It firstly offers an overview of the considerable empirical literature around teaching—especially conceptions of teaching, approaches to teaching and teaching practices—and goes on to pose some philosophical and social theoretical considerations that open further the territory around teaching in university. Against this background, we propose the concept of ‘horizons of teaching’. Horizons of teaching provide a context in which it makes sense for teachers to give themselves to the teaching enterprise and to go on giving themselves to teaching. Horizons include diverse and intricate layers at both micro- and macro-levels that interact in a permanent and dynamic way; they involve persons and collectivities; and they concern structures and agency. The paper concludes by proposing that horizons of teaching configure and delineate curricula and the pedagogical relationship in a way that might contain a revolutionary potentiality in recasting teaching in higher education.     

The relationship between motivation to read and reading comprehension in chilean elementary students

This study examined the role of reading motivation in reading comprehension achievement of 1070 Chilean third, fourth, and fifth-grade students enrolled in public and private schools. Students were assessed in Spanish reading comprehension and were administered the Motivation to Read Profile from Gambrell, Palmer, Codling and Mazzoni (1996), at the beginning and end of the school year. Results showed that motivation to read at the beginning of the school year was significantly associated with gains in reading comprehension skills. When disaggregating motivation into self-concept and value of reading, only self-concept of reading significantly predicted gains in reading comprehension. Moderation analyses showed that students that started the year with lower reading comprehension and higher motivation to read, had significantly better reading comprehension at the end of the school year, than their peers who started with lower reading motivation. The pedagogical implications are discussed.

     

Sport education-based irregular teaching unit and students’ physical activity during school recess

Abstract

The aim of the study was to compare the effect of a Sport Education-based irregular teaching unit on the high-school students’ physical activity (PA) during school recess. A sample of 91 adolescents (45 girls) aged 13–16?years old met the exclusion criteria. The six classes were cluster-randomly assigned to the Irregular Sport Education group (Sport Education methodology with competitions in recess), Traditional Sport Education group (Sport Education methodology with competitions in Physical Education lessons), or to the control group (non-intervention). The students’ PA during school recess periods were objectively assessed by GT3X accelerometers. The results of the repeated-measures nested analysis of variance showed that the Sport Education-based irregular teaching unit significantly improved the students’ PA during recesses (p?<?0.001). The competitions phase of the Sport Education model performed at school recesses seems to be a valuable strategy for increasing students’ PA contributing to the achievement of the daily recommendations.     

“Nobody Really Wants to be Called Bossy or Domineering”

This article examines talks given by 12 female media professionals at a Southern US university’s center on women in communication between 2013 and 2015 to identify the influence of hegemonic masculinity in industry speak about women and professionalism in the fields of journalism, advertising, and public relations. This paper applies a feminist critique of discussions about “work–life balance,” “leaning in,” “emotion,” and language about the role of technology and innovation in women’s careers, to argue that inherent in these discussions about media professionalism are traits that perpetuate binary notions of feminine–masculine traits of the workplace. As a whole, these messages fail to account for notions of intersectionality and perpetuate inequality and masculine power for future professionals.     

‘I'm ready for a new chapter’: The voices of young people with autism spectrum disorder in transition to post-16 education and employment

This study explores the views and experiences of 12 young people with autism spectrum disorder (ASD) in transition to post-16 education and employment, in light of the changes introduced by the new special educational needs and disability (SEND) legislation in England. The extension of provision until the age of 25, and the introduction of person-centred education, health and care (EHC) plans, have given a significant place to the views of young people with SEND and their families. The views, wishes and aspirations of young people must be captured in the newly developed plans, reflecting the statutory requirement for local authorities to systematically record these in a biopsychosocial way, focusing on participation and well-being. Twelve semi-structured interviews were conducted with young people with ASD attending specialist settings or receiving specialist support under the new EHC plans. These were analysed inductively, through thematic analysis. The findings suggest that at the time of transition, young people with ASD want to become increasingly more independent, present ambivalent feelings about their future and acknowledge the relevance of support systems in their lives. Implications for practice and future research are discussed, in light of the new English policy context.