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Li?Wang Ainiwaer?Aikemu Ayiguli?Yibulayin Shuli?Du Tingting?Geng Bo?Wang Yuan?Zhang Tianbo?JinEmail author Jie?YangEmail author 《BMC genetics》2015,16(1):66
Background
Drug response variability observed amongst patients is caused by the interaction of both genetic and non-genetic factors, and frequencies of functional genetic variants are known to vary amongst populations. Pharmacogenomic research has the potential to help with individualized treatments. We have not found any pharmacogenomics information regarding Uygur ethnic group in northwest China. In the present study, we genotyped 85 very important pharmacogenetic (VIP) variants (selected from the PharmGKB database) in the Uygur population and compared our data with other eleven populations from the HapMap data set.Results
Through statistical analysis, we found that CYP3A5 rs776746, VKORC1 rs9934438, and VKORC1 rs7294 were most different in Uygur compared with most of the eleven populations from the HapMap data set. Compared with East Asia populations, allele A of rs776746 is less frequent and allele A of rs7294 is more frequent in the Uygur population. The analysis of F-statistics (Fst) and population structure shows that the genetic background of Uygur is relatively close to that of MEX.Conclusions
Our results show significant differences amongst Chinese populations that will help clinicians triage patients for better individualized treatments.2.
Study on the mechanism of the interaction between acteoside and pepsin using spectroscopic techniques 下载免费PDF全文
Yifeng Fang Hong Xu Liangliang Shen Fengwen Huang Shadaiti Yibulayin Songyang Huang Shengli Tian Zhangli Hu Zhendan He Fangrong Li Yinong Li Kai Zhou 《Luminescence》2015,30(6):859-866
The interaction of acteoside with pepsin has been investigated using fluorescence spectra, UV/vis absorption spectra, three‐dimensional (3D) fluorescence spectra and synchronous fluorescence spectra, along with a molecular docking method. The fluorescence experiments indicate that acteoside can quench the intrinsic fluorescence of pepsin through combined quenching at a low concentration of acteoside, and static quenching at high concentrations. Thermodynamic analysis suggests that hydrogen bonds and van der Waal's forces are the main forces between pepsin and acteoside. According to the theory of Förster's non‐radiation energy transfer, the binding distance between pepsin and acteoside was calculated to be 2.018 nm, which implies that energy transfer occurs between acteoside and pepsin. In addition, experimental results from UV/vis absorption spectra, 3D fluorescence spectra and synchronous fluorescence spectra imply that pepsin undergoes a conformation change when it interacts with acteoside. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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