城市区域多物流无人机协同任务分配

针对城市区域多无人机协同物流任务分配问题, 综合考虑不同无人机性能、物流时效性、飞行可靠性等影响因素, 以经济成本、时间损失和安全风险最小为目标函数, 构建多无人机协同物流任务分配模型。因问题规模大、求解复杂度高, 设计改进的量子粒子群算法进行求解。首先，为增强粒子遍历性和多样性, 采用均匀化级联Logistic映射进行粒子初始化; 其次，为避免算法陷入局部最优解, 引入基于高斯分布的粒子变异方式; 最后，为提高算法运行效率, 运用自适应惯性权重方法对粒子赋值。仿真实验结果表明，所构建的模型能够实现任务分配多目标优化, 贴近城市区域无人机物流配送实际; 所提算法与传统量子粒子群算法和遗传算法相比, 任务分配代价分别下降了5.9%和6.3%;并进一步对参数权重设置进行分析, 当3个子目标函数权重系数分别为0.225、0.275和0.500, 种群规模为150时, 算法规划的结果最优。     

土壤肥料学实验课程的教学改革与实践

为全面培育卓越农林人才，提高教学培养质量，本研究结合土壤肥料学的课程内容、教学特点及实验方法，对存在的问题进行了剖析，并结合实际针对存在问题做出了相应改革，适时调整《土壤肥料学》实验课程内容和形式。通过删减验证性实验内容，增设综合性实验，传统部分教学内容实现网络化等三方面对该课程的实验课部分进行了改革与实践，以期提高学生综合运用所学《土壤肥料学》的相关知识来解决生产实际问题的能力。     

第十二种孤独——从《复活节游行》解读理查德·耶茨“孤独的女性”主题

发表于1976年的《复活节游行》是美国现代作家理查德·耶茨的"女性小说"。在作品中,耶茨从一个男性作家的视角,细致入微地描写了上世纪70年代美国都市普通家庭两姐妹,用犀利但满含怜悯的笔触展示了以主人公艾米莉一家为代表的孤独的女性群体,是作家在其短篇小说集《十一种孤独》之后所描述的"第十二种孤独"——女性孤独。从孤独的女性主题着手,以《复活节游行》的分析为突破口,结合存在主义探讨作家对女性孤独的理解,并试图找到破解现代人孤独的钥匙。     

几个广义Apostol-Bernoulli、Apostol-Euler多项式之间的关系式

利用发生函数理论结合某些运算技巧,推出了几个广义Apostol-Bernoulli多项式、广义Apostol-Euler多项式之间的关系式.多个参数出现在等式中,非常工整.在关系式中选取适当的参数,就可以得到已有的著名的关于广义Bernoulli多项式、广义Euler多项式之间的关系式,从而深化和推广了对Bernoulli数、Euler数、Bernoulli多项式、Euler多项式的相关研究结果.     

兰州黄河岸边卵石层大吨位桩基自平衡法试验研究

对兰州深安黄河大桥进行桩基自平衡法试验。在对黄河岸边的岩土层进行桩基试验时,对桩基的极限侧阻力和端阻力标准值的取值提出建议,并在兰州地区进行自平衡法桩基试验时,对桩基侧摩阻力的取值提出建议。     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

The modernity of Dedekind’s anticipations contained in What are numbers and what are they good for?

Archive for History of Exact Sciences - We show that Dedekind, in his proof of the principle of definition by mathematical recursion, used implicitly both the concept of an inductive cone from an...