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排序方式: 共有2673条查询结果,搜索用时 31 毫秒
1.
Takashi Ohnishi Yuki Ogawa Kota Suda Miki Komatsu Satoko Matsumoto Harmon Mitsuru Asukai Masahiko Takahata Norimasa Iwasaki Akio Minami 《International journal of molecular sciences》2021,22(9)
Pyogenic spondylodiscitis can cause severe osteolytic and destructive lesions in the spine. Elderly or immunocompromised individuals are particularly susceptible to infectious diseases; specifically, infections in the spine can impair the ability of the spine to support the trunk, causing patients to be bedridden, which can also severely affect the physical condition of patients. Although treatments for osteoporosis have been well studied, treatments for bone loss secondary to infection remain to be elucidated because they have pathological manifestations that are similar to but distinct from those of osteoporosis. Recently, we encountered a patient with severely osteolytic pyogenic spondylodiscitis who was treated with romosozumab and exhibited enhanced bone formation. Romosozumab stimulated canonical Wnt/β-catenin signaling, causing robust bone formation and the inhibition of bone resorption, which exceeded the bone loss secondary to infection. Bone loss due to infections involves the suppression of osteoblastogenesis by osteoblast apoptosis, which is induced by the nuclear factor-κB and mitogen-activated protein kinase pathways, and osteoclastogenesis with the receptor activator of the nuclear factor-κB ligand-receptor combination and subsequent activation of the nuclear factor of activated T cells cytoplasmic 1 and c-Fos. In this study, we review and discuss the molecular mechanisms of bone loss secondary to infection and analyze the efficacy of the medications for osteoporosis, focusing on romosozumab, teriparatide, denosumab, and bisphosphonates, in treating this pathological condition. 相似文献
2.
Seung Han Ryu Seil Kim Young-Tae Kwon Young Ki Park Sung-Oong Kang Hong-Baek Cho Yong-Ho Choa 《应用聚合物科学杂志》2020,137(8):48390
Here, we report a facile approach to electrostatically couple the surface charges of graphite nanoplate (GNP) fillers and poly(methyl methacrylate) (PMMA) polymer particles using ethylene maleic anhydride (EMA) copolymer as an electrostatic coupling agent. Our strategy involved switching the intrinsic repulsive electrostatic interactions between the directly exfoliated GNPs fillers and the PMMA particles to attractive electrostatic surface interactions for preparing core(PMMA)-shell (GNP) precursor in order to optimizing 3-dimensionally dispersed polymer nanocomposite. As a result, the electrical conductivity of the composites dramatically increased by a factor of 16.7 in the EMA-coupled GNP/PMMA composites compared with that of the EMA-free GNP/PMMA composites. In addition, the percolation threshold was also notably reduced from 0.32 to 0.159 vol% after electrostatic coupling of the GNPs fillers and PMMA particles. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137, 48390. 相似文献
3.
This paper presents a low‐cost RF parameter estimation technique using a new RF built‐in self‐test (BIST) circuit and efficient DC measurement for 4.5 to 5.5 GHz low noise amplifiers (LNAs). The BIST circuit measures gain, noise figure, input impedance, and input return loss for an LNA. The BIST circuit is designed using 0.18 μm SiGe technology. The test technique utilizes input impedance matching and output DC voltage measurements. The technique is simple and inexpensive. 相似文献
4.
Woo Gon Kim Sung Ho Kim Woo Seog Ryu 《Journal of Mechanical Science and Technology》2002,16(11):1420-1427
The Monkman-Grant (M-G) and its modified parameters were evaluated for type 316LN and modified 9Cr-Mo stainless steels prepared
with minor element variations. Several sets of creep data for the two alloy systems were obtained by constant-load creep tests
in 550-650°C temperature range. The M-G parameters,m, m’,C, andC’ were proposed and discussed for the two alloy systems. Them value of the M-G relation was 0.90 in type 316LN steel and 0.84 in modified 9Cr-Mo steel. Them’, value of the modified relation was 0.94 in type 316LN steel and 0.89 in 9Cr-Mo steel. Although creep fracture modes and
creep properties between type 316LN and modified 9Cr-Mo steels showed a basic difference, the M-G and its modified relations
demonstrated linearity quite well. Them’ of modified relation almost overlapped regardless of the creep testing conditions and chemical variations in the two alloy
systems, and the parameterm’ was closer to unity than that of the M-G relation. 相似文献
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7.
T. Takeuchi T. Sasaki M. Hayashi K. Hamamoto K. Makita K. Taguchi K. Komatsu 《Photonics Technology Letters, IEEE》1996,8(3):361-363
A transceiver PIC consisting of a DFB-LD, a receiver PD and a Y-shaped branch waveguides is realized by in-plane bandgap energy controlled selective MOVPE. Both active and passive core layers are formed in one step selective growth, and complicated fabrication procedure is no longer required. More than 1 mW fiber coupled power and 7 GHz receiver bandwidth are obtained. The modulation and detection operations at 500 Mb/s are successfully demonstrated. 相似文献
8.
Hiroshi Ito Takehiko Ishiguro Tokutaro Komatsu Nozomu Matsukawa Gunzi Saito Hiroyuki Anzai 《Journal of Superconductivity and Novel Magnetism》1994,7(3):667-669
The superconducting transition of the organic compoundsκ-(BEDT-TTF)2 X is studied by resistive measurement in a magnetic field up to 10 T applied normal to the conducting plane. For the salts withX=Cu[N(CN)2]Br andX=CuCN[N(CN)2] the transition shows fanshaped broadening caused by superconductivity fluctuation. For theX=Cu(NCS)2 salt the resistivity shows a peak in the transition region in a magnetic field below 4 T.This phenomenon is suppressed in defect-reduced samples for intralayer conduction. We discuss this peak in relation to the thermal fluctuation on the Josephson junction structures in this salt. 相似文献
9.
A compact dipole antenna for the terrestrial digital multimedia broadcasting (TDMB) application is presented. The length of the antenna is about 0.06λ at the TDMB resonance frequency of 190 MHz. Miniaturization of the antenna is achieved by using meander structures and lumped elements. The proposed antenna has two resonance frequencies and covers the TDMB band from 174 MHz to 216 MHz in Korea. The antenna has good impedance bandwidth and radiation characteristics for the TDMB. The experimental results of the designed dipole antenna are presented and analyzed. 相似文献
10.
Advances in internet congestion control 总被引:1,自引:0,他引:1
Ryu Seungwan Rump Christopher Qiao Chunming 《Communications Surveys & Tutorials, IEEE》2003,5(1):28-39
In this survey, we first review the concept of congestion control with a focus on the Transmission Control Protocol⁄Internet Protocol (TCP⁄IP). We describe many recently proposed algorithms to combat congestion and improve performance, particularly active queue management (AQM) algorithms such as random early detection (RED) and its variants. We then survey control-theoretic analysis and design of TCP congestion control with an AQM scheme. In addition, we discuss three problems associated with AQM proposals: parameter setting, the insensitivity to the input traffic load variation, and the mismatch between macroscopic and microscopic behavior of queue length dynamics. As alternatives to AQM algorithms, we also survey architectural approaches such as modification of source or network algorithms, and economic approaches including pricing or optimization of allocated resources. Finally, we list many open issues that persist in the design, operation, and control of the Internet. 相似文献