Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups

Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The anti liver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the anti hepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an anti hepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an anti hepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group".     

幼儿泛发性扁平黄瘤1例

患儿女，2岁，头面部黄色斑片1年半，渐累及躯干、外阴。皮肤科情况：头面部、躯干、外阴可见多发大小不一的黄色斑片，约绿豆至豌豆大小，边界清，表面光滑，未见丘疹、斑丘疹、鳞屑、萎缩、糜烂、坏死等。腹部皮损组织病理示：真皮上部可见弥漫泡沫细胞浸润，伴有淋巴细胞浸润。诊断：泛发性扁平黄瘤。     

『望子成龙』背后,请找到你自己

2月份后,精神心理科的门诊量大增,“高三党”和学生家长越来越多,多是因为高考将近,家长们希望医生能够帮孩子调整到合适的应考状态.满满是这些孩子中,最为乖巧的一个.     

汪机佚书《本草会编》内容特点探究

明朝徽州祁门人汪机编撰的《本草会编》早已亡佚，但借助从李时珍《本草纲目》中辑出的71条，发现《本草会编》的内容有纠错、解释、心得、评议、摘引、置疑等特点，这些正是得到李时珍肯定的主要内容。     

静息态功能磁共振在血管性轻度认知障碍研究中的 应用进展

血管性认知障碍作为脑血管病致残结果之一，其发病率仅次于AD，成为与年龄相关的认 知障碍和痴呆的第二大原因。目前血管性痴呆尚无有效的治疗措施，而血管性轻度认知障碍（VaMCI） 作为血管性痴呆的早期阶段被认为是临床上治疗、预防痴呆的关键时期，也是当今血管性认知障碍研 究的热点。近年来静息态功能磁共振成像技术的快速发展及其在认知领域的广泛应用使我们更加深入 的了解VaMCI 患者在神经结构、功能、代谢等方面的变化，为早期诊断、评估疾病严重程度及治疗效果 带来了新的希望。将静息态功能磁共振用于该病并将其与神经心理学评估结合用来诊断VaMCI将会成 为未来的趋势。     

A novel surgical technique to prevent post-enucleation conjunctival cyst:conjunctival staining with methylthioninium

Dear Editor,Conjunctival cyst of the orbit acquired from enucleation is an infrequent but serious complication;which can occur in 3%-7%of patients,more commonly after a secondary procedure;.The most common manifestations are the inability to retain the external prosthesis.     

初产妇实施母乳喂养集束化管理的效果研究

目的 探讨实施母乳喂养集束化管理对提高初产妇母乳喂养知识和母乳喂养率的效果。方法 选取庐江县人民医院产科2016年7月至2018年6月收治的200例初产妇为研究对象，按照入院时间先后将前100例设为对照组，后100例设为观察组。对照组实施母乳喂养的常规宣教及护理，观察组实施母乳喂养集束化管理，观察两组产妇分娩后24小时、48小时、72小时、3个月及6个月的母乳喂养率，比较两组产妇出院前1天的母乳喂养知识得分。结果 观察组在分娩后24小时、48小时、72小时、3个月及6个月的母乳喂养率高于对照组，差异有统计学意义（P<0.05），观察组母乳喂养知识得分为（86.67±5.16）分，高于对照组的（78.38±4.57）分，差异有统计学意义（P<0.05）。结论 实施母乳喂养集束化管理能提高初产妇母乳喂养率，并提高初产妇的母乳喂养知识。