子宫颈上皮不典型增生与宫颈癌细胞超微结构的观察比较

光镜和电镜观察慢性宫颈炎上皮不典型增生42例,宫颈癌21例,正常对照7例。上皮不典型增生之一是位于深部的储备细胞增生,细胞的核质比大,细胞器少,分化较低。鳞状上皮不典型增生细胞特点是核质比增大,核形不整,核膜内陷,细胞器增多,桥粒和张力原纤维减少。鳞癌细胞的核质比更大,核膜内褶深,细胞器更多,桥粒和张力原纤维很少或消失,分化低的癌细胞尤明显。粘液性腺癌腺上皮深部可见储备细胞转化的癌细胞。     

LRH-A对人胎盘和妊娠大鼠脑垂体-卵巢-子宫及胎盘作用的研究

本文研究大剂量LRH-A对人早孕胎盘绒毛、大鼠的脑垂体、卵巢、子宫和胎盘的作用。实验结果表明,大剂量LRH-A可使妊娠大鼠子宫内膜、胎盘淤血坏死,胚胎发育停滞,黄体退变及局灶性坏死,黄体细胞3β-HSD酶活性显著减弱,但大鼠垂体促性腺激素细胞超微结构没有受到明显影响。LRH-A可促进体外培养人绒毛hCG的分泌,并损害绒毛上皮的组织结构。     

铅影响胚胎发育机理的实验研究

采用光镜、电镜、酶组织化学定性定量分析及原子吸收分光光度计等多种方法,系统地研究了孕鼠血铅浓度与胚胎毒性、母体代谢以及孕鼠脑垂体——卵巢——胎盘轴器官损害程度之间的关系。结果表明:当血铅浓度达亚中毒水平时(487.7μg/L±161.5μg/L),即表现明显胚胎毒性;同时孕鼠的卵巢、胎盘及全身代谢亦受到明显损害。这说明铅的胚胎毒性作用是通过影响母体代谢、卵巢内分泌功能、胎盘的生理功能以及对胚胎的直接毒性等综合作用的结果。     

HUMAN ANTIFE.RTILITY EFFECT OF GOSSYPOL CYTOLOGIC OBSERVATION OF SEMEN

Monthly semen samples of 28 fertile men treated with 15-20 mg/day enteric-coated gossy- pol tablets, formic acid gossypol or acetic acid gossypol were examined by light microscope and electron microscope until antifertility was reached. Some cases were also studied ultra- histochemically for adenosine triphosphatase activity. The controls were the subjects' own samples before treatment. By counting the morphologic changes of the spermatozoa, it was found that gossypol may cause marked 30% t0 69% increases in abnorma- lities l.5 months after the start of administration. Electron microscope showed that the heads of aberrant spermatozoa often presented with large vacuoles with membranous structures in the nu- clei and the acrosomes of some cells were abnor- mal or even completely lacking. The middle- pieces had irregularly arranged mitochondria and the cristae were decreased or even absent and the matrix became paler. The mitochondria were vacuolated. Control ATPase positive reac- tions on the outer and inner mitochondrial mem- branes were in general stronger than in the gossypol treated and the vacuolated mitochond- ria always were negative. As the drug took effect, the spermatogenic cells, mainly spermatids, were markedly increas- ed t0 10-100% and some spermatids had 2 t0 4 nuclei. Sertoli's cells were seen in the semen. In general, the higher the cell differentia- tion, the more gossypol sensitive it is.     

口服米非司酮配伍米索前列醇与阴道置米索前列醇终止妊娠蜕膜和胎盘超微结构的比较性研究

从超微结构水平，比较口服米非司酮配伍米索前列醇（米索）与单独阴道放置米索终止妊娠后蜕膜及胎盘超微结构的改变。将１２～２２孕周要求终止妊娠的孕妇１６例随机分为３组：组Ｉ（６例），口服米非司酮（５０ｍｇ，２次／日×２天）后加服米索（０．２ｍｇ／４ｈ）；组Ｉ（５例），阴道单独置米索（０．２ｍｇ／１２ｈ），组ＩＩ（５例）水囊引产作为正常对照。结果：组Ｉ与组Ｉ蜕膜及胎盘超微结构均有影响，其中，对蜕膜的影响组Ｉ较组ＩＩ更为明显，对胎盘绒毛滋养细胞的影响组Ｉ较组Ｉ更显著。表明米非司酮终止妊娠主要通过对孕激素作用的阻断而直接影响蜕膜；米索阴道用药则可能主要通过影响子宫血供而使胎盘绒毛结构发生明显改变。     

铅对孕鼠脑垂体—卵巢—胎盘轴及人绒毛毒性作用的研究

铅有胚胎毒作用,可致畸或流产及死胎,铅可经胎盘入胎体直接影响胚胎的发育,或通过对母体的影响而波及胚胎。但铅对胎盘毒作用的机制及其量效关系至今仍不甚明了。本文观察铅对孕鼠脑垂体-卵巢-胎盘轴的毒性作用和血铅浓度与这些器官损害程度之间的关     

STn抗原在子宫颈鳞状细胞肿瘤中的表达

ＳＴｎ抗原在子宫颈鳞状细胞肿瘤中的表达周先荣童夙明杜心谷ＳＴｎ抗原是Ｔｎ抗原的唾液酸形式，Ｔｎ抗原广泛存在于肺、结肠、膀胱等部位的肿瘤组织中，在正常组织仅有极微量表达［１］。因此，探索这些抗原在不同组织恶性转化过程中表达的改变，对了解细胞表面结构特征...     

血型相关性抗原和Sialy—Tn抗原在女性胎儿生殖器官的表达

应用免疫组织化学方法探讨Ｈ、Ｌｅｗｉｓ－ａ，Ｌｅｗｉｓ－ｂ，Ｌｅｗｉｓ－ｘ，Ｌｅｗｉｓ－ｙ，Ｓｉａｌｙｌ－Ｌｅｗｉｓ－ａ，Ｓｉａｌｙｌ－Ｌｅｗｉｓ－ｘ，Ｓｉａｌｙｌ－ｄｉｍｅｒｉｃ－Ｌｅｗｉｓ－ｘｉ和Ｓｕｉａｌｙｌ－Ｔｌ等９种糖抗原在人胎儿卵巢，子宫和阴道中的表达。卵巢卵母细胞的胞质中机见ＳＬｘ，Ｌａ及Ｌｂ抗原的表达，并随胎龄增长而增多。     

口服长效避孕药炔雌醚及其辅药对子宫内膜影响的电镜观察

环戊醚乙炔雌二醇(简称炔雌醚)与氯地孕酮或18甲基炔诺酮等配伍的长效口服避孕药,临床试用每月口服一次即可达到避孕效果。经过不断的改进与减量服用,克服了一些不良反应,成为一种简便有效的避孕药。Greenblatt等对服炔雌醚治疗的妇女子宫内膜进行组织学观察;每天服150微克炔雌醚,累积量至9.5～12毫克时,内膜出现轻度至腺囊型增生过长。