Effect of 935-MHz phone-simulating electromagnetic radiation on endometrial glandular cells during mouse embryo implantation

This study examined the impact of 935MHz phone-simulating electromagnetic radiation on embryo implantation of pregnant mice.Each 7-week-old Kunming (KM) female white mouse was set up with a KM male mouse in a single cage for mating overnight after induction of ovulation.In the first three days of pregnancy,the pregnant mice was exposed to electromagnetic radiation at low-intensity (150 μW/cm2,ranging from 130 to 200 μW/cm2,for 2-or 4-h exposure every day),mid-intensity (570 μW/cm2,ranging from 400 to 700 μW/cm2,for 2-or 4-h exposure every day) or high-intensity (1400 μW/cm2,ranging from 1200 to 1500 μW/cm2,for 2-or 4-h exposure every day),respectively.On the day 4 after gestation (known as the window of murine embryo implantation),the endometrium was collected and the suspension of endometrial glandular cells was made.Laser scanning microscopy was employed to detect the mitochondrial membrane potential and intracellular calcium ion concentration.In high-intensity,2-and 4-h groups,mitochondrial membrane potential of endometrial glandular cells was significantly lower than that in the normal control group (P<0.05).The calcium ion concentration was increased in low-intensity 2-h group but decreased in high-intensity 4-h group as compared with the normal control group (P<0.05).However,no significant difference was found in mitochondrial membrane potential of endometrial glandular cells between low-or mid-intensity groups and the normal control group,indicating stronger intensity of the electromagnetic radiation and longer length of the radiation are required to inflict a remarkable functional and structural damage to mitochondrial membrane.Our data demonstrated that electromagnetic radiation with a 935-MHz phone for 4 h conspicuously decreased mitochondrial membrane potential and lowered the calcium ion concentration of endometrial glandular cells.It is suggested that high-intensity electromagnetic radiation is very likely to induce the death of embryonic cells and decrease the chance of their implantati     

妊娠合并上腹痛2例报道

上腹痛是妊娠期间常见症状,多见于急性胃肠道疾病,但一些妊娠期的并发症也会伴发上腹痛,如妊娠高血压综合征(HELLP综合征)以及妊娠期急性脂肪肝(acute fatty liver ofpregnancy,AFLP),故应该仔细辨别,以便能及早发现病情,及时终止妊娠,改善母儿预后。1临床资料病例:患者,岁,初产妇,因"停经个月,头痛伴上腹     

既往分娩史对剖宫产后阴道试产结局的影响

目的:探讨既往分娩史对剖宫产后阴道试产(TOLAC)患者成功率的影响。方法:回顾性分析2013年7月至2016年3月尝试TOLAC的瘢痕子宫孕妇的资料(妊娠≥28周),共506例,其中阴道分娩成功414例(TOLAC成功组),中转剖宫产92例(TOLAC中转剖宫产组)。比较两组前次剖宫产时间、剖宫产指征、阴道分娩史、新生儿存活情况等。结果:TOLAC中转剖宫产组的孕前体质量指数(BMI)及新生儿出生体质量大于TOLAC成功组(P0.05),两组平均妊娠间隔时间比较差异无统计学意义(P0.05),两组在妊娠间隔1年、1~2年、2~3年、3年的比例分别比较,差异无统计学意义(P0.05)。两组的前次剖宫产指征分别比较,差异均无统计学意义(P0.05)。TOLAC成功组有阴道分娩史患者比例明显高于TOLAC中转剖宫产组(P0.05),新生儿未存活的比较差异无统计学意义(P0.05)。结论:既往有阴道分娩史是TOLAC成功的有利因素,而既往分娩史的其他因素对TOLAC的成功率影响较小。     

胎膜早破与绒毛膜羊膜炎关系的临床分析

目的:研究胎膜早破与绒毛膜羊膜炎的临床关系。方法:收集我院2009-01～12的250例胎膜早破患者,计算其中绒毛膜羊膜炎的发生率,以及分析有关的导致绒毛膜羊膜炎的危险因素。结果:在250例胎膜早破患者中,绒毛膜羊膜炎的总发生率约为20%,其中在未足月的胎膜早破患者中,绒毛膜羊膜炎的发生率高于足月的胎膜早破患者,两者比较差异有显著性;既往有阴道炎的胎膜早破患者发生绒毛膜羊膜炎的机率高于无阴道炎的患者,两者比较差异有显著性,而患有妊娠期糖尿病的胎膜早破患者发生绒毛膜羊膜炎的机率并无增加。结论:胎膜早破的患者应该严格监测,积极行抗感染治疗,特别是既往有阴道炎的患者,阴道炎可以作为发生绒毛膜羊膜炎的一个独立的因素,在积极治疗的前提下及时终止妊娠,缩短分娩时间,改善母儿结局。     

剖宫产后再次妊娠阴道分娩意愿的影响因素探讨

目的:探讨剖宫产后再次妊娠患者阴道分娩意愿的相关影响因素。方法:选取2015年3月至2018年12月在昆明医科大学第一附属医院产科门诊进行首诊建档(通常在孕早期)的剖宫产后再次妊娠患者,在门诊护士的专业指导下进行问卷调查,分析影响瘢痕子宫患者阴道分娩意愿的影响因素。结果:收集调查问卷共1589份,其中愿意尝试TOLAC者1043例(65.64%)。家庭月收入>10000元[OR=0.63,95%CI(0.48~0.83)]和前次剖宫产指征为母亲要求[OR=0.59,95%CI(0.43~0.80)]降低了瘢痕子宫患者对TOLAC的接受度,而瘢痕子宫患者再次妊娠前了解TOLAC的利与弊[OR=3.93,95%CI(3.05~5.06)]可提升患者对TOLAC的接受度。结论:家庭收入高、前次剖宫产为母亲要求降低瘢痕子宫患者的阴道分娩意愿,而对TOLAC的了解认知可提升瘢痕子宫患者阴道分娩的意愿。     

妊娠反应与孕期抑郁的关联研究

  目的  探讨妊娠反应相关情况与孕期抑郁之间的关联。  方法  以在云南省3家医院进行产前检查的孕妇为研究对象,通过自制问卷收集孕妇信息,采用爱丁堡产后抑郁量表评定孕期抑郁。用卡方检验描述不同特征孕妇孕期抑郁发生情况,Logistic回归分析妊娠反应相关情况与孕期抑郁的关联。   结果  纳入6 075名孕妇,孕期抑郁的检出率为35.64%。单因素分析结果显示,不同年龄、婚姻状况、居住地、职业状况、家庭年收入、文化程度、孕期、反应剧烈程度、反应持续时间和现阶段反应是否结束的孕妇孕期抑郁发生,差异均具有统计学意义（P < 0.05）。多因素结果显示,妊娠反应剧烈程度剧烈、持续10周及以上和反应尚未结束的孕妇发生孕期抑郁的风险增高。   结论  妊娠反应的剧烈程度和持续时间、目前反应是否结束与孕期抑郁存在关联。应加强妊娠相关知识的普及,减少孕期抑郁的发生,提高孕妇的心理健康水平。