BNP联合Tei指数对AECOPD患者右心功能的评价作用

目的:探讨血清脑钠肽(BNP)联合彩色多普勒超声心动图测定右心室Tei指数对评价慢性阻塞性肺疾病急性加重期(AECOPD)患者右心室功能的价值。方法:96例AECOPD患者入选观察组,85例健康体检人员为对照组,分别测定对照组、观察组及观察组缓解期患者血清BNP与右心室Tei指数。结果:观察组患者的血清BNP高于对照组和观察组缓解期,差异均有统计学意义(P<0.05)。观察组患者缓解期血清BNP高于对照组,差异有统计学意义(P<0.05)。观察组患者的Tei指数高于对照组和观察组缓解期,差异均有统计学意义(P<0.05)。观察组缓解期患者的Tei指数高于对照组,差异有统计学意义(P<0.05)。观察组患者的血清BNP与Tei指数正相关(γ=0.89,P=0.007);观察组患者的Tei指数与FEVl(%)、FEVl/FVC负相关(γ=-0.87,-0.89,P=0.015)。结论:血清BNP与右心室Tei指数可全面准确地评价AECOPD患者的右心室功能状态。     

上皮钙粘素-链接素复合体与头颈部肿瘤关系的研究进展

E-钙粘素是一种细胞-细胞间粘附分子，与链接素结合形成复合体既介导同种细胞间粘附反应，又可通过β链接素调控细胞周期进程，在肿瘤的生成、浸润和转移中发挥重要作用。在头颈部肿瘤中已经发现E-钙粘素-链接素复合体表达明显下调，本就该复合体在肿瘤发生、发展中的作用及它的表达与头颈部肿瘤的关系进行综述。     

淋巴结传染性单核细胞增多症一例

1　病例患者男 ,2 0岁 ,以发热伴咽部不适9天入院。患者自述 9天前踢球后自觉发热 ,伴咽部不适 ,鼻塞、流涕 ,偶有干咳。体检 :体温 37.8℃ ,皮肤无黄染 ,扁桃体轻度肿大 ,咽部充血 ,双侧颈部及腹股沟可及多枚肿大淋巴结 ,双肺 (一 ) ,肝肋下未及 ,脾肋下 1cm。实验室检查 :白细胞 13× 10 9/L ,淋巴细胞 6 5 .8% ,红细胞 4 .5 2× 10 12 /L ,单核细胞 0 .7× 10 9/L。血涂片 :粒红系增生活跃 ,巨核细胞数量增多 ,成熟淋巴细胞 2 5 % ,可见异型淋巴细胞。血生化 :谷丙转氨酶 5 4 2U/L ,谷草转氨酶 5 13U/L。各项抗体检查 :患者发病第 9天…     

ERG基因及其与前列腺癌关系

因属于ETS转录因子家族,在很多肿瘤中高表达,与肿瘤的血管生成、转移、浸润、抑制凋亡有关,ERG基因在前列腺癌中主要受TMPRSS2-ERG融合基因的调节。近一半以上的前列腺癌病例表达TMPRSS2-ERG融合基因,其中ERG基因可能是前列腺癌的重要标志物,它的检测有助于前列腺癌的诊断和治疗方法的选择。TMPRSS2-ERG融合基因的存在还会影响前列腺癌病人的预后。本文就ERG基因的生物学特征、作用机制、TMPRSS2-ERG的融合机制以及ERG基因与前列腺癌的诊断、治疗和预后的关系作一综述。     

β-防御素在慢性鼻-鼻窦炎和正常鼻黏膜中的表达

近年来研究表明，鼻黏膜及黏膜下腺体中存在大量的免疫活性细胞并分泌大量的生物活性分子，如各类白介素、溶菌酶、抑菌肽等。研究这些生物活性分子对如何提高鼻腔黏膜的防御功能及慢性鼻-鼻窦炎的防治有重要意义。人类β-防御素（human β-defensins，hBD），包括hBD-1和hBD-2是近几年发现的广泛分布于口腔、呼吸道、胃肠道、泌尿道黏膜上皮及黏膜下腺体组织的重要蛋白质分子，     

肾混合性上皮间质肿瘤和成人囊性肾瘤的临床病理学观察

Objective To study the clinicopathologie features,immunophenotype and differential diagnosis of mixed epithelial and stromal tumor of kidney ( MEST) and adult cystic nephroma ( CN).Methods Five cases of MEST and 4 cases of CN were retrospectively analyzed.Immunohistochemical study was carried out and the literature was reviewed.Results All of the five patients with MEST were females.Their median age was 45 years.For CN,there were 3 males and 1 female and their median age was 41 years.All patients presented with loin pain and hematuria.On gross examination,MEST was well-circumscribed but non-encapsulated.There was no evidence of haemorrhage or necrosis.Three of the cases were solid in nature.One was composed of a mixture of solid and cystic elements,while the remaining case showed a multicystic cut surface bridged by thick fibrous septa.On the other hand,CN were well-circumscribed and encapsulated.They were multiloculated cystic in nature.The cystic spaces were separated by thin septa and there was no significant solid or necrotic component.Histologically,MEST consisted of proliferation of cystically dilated glands admixed with spindly stromal cells with various cellularity and growth patterns.Both the glandular and stromal elements were well-differentiated with no cytologic atypia identified.The glandular structures in 2 of the cases were partially lined by endometrial or tubal epithelium.In contrast,the thin-walled cystic spaces in CN were lined by a single layer of epithelium.Immunohistochemical　study showed that the epithelial cells were positive for pan-cytokeratin and epithelial membrane antigen.The spindle cells in MEST expressed vimentin (5/5 ) ,smooth muscle actin (3/5 ),desmin (4/5 ),CD10 (5/5),estrogen receptor (4/5) and progesterone receptor (4/5).They were negative for HMB45,CD34,CD117 and S-100 protein.On the other hand,the spindle cells in CN were variably positive for vimentin (4/4),smooth muscle actin (4/4),desmin (1/4),estrogen receptor (3/4) and progesterone receptor (1/4).They were negative for CD10,HMB45,CD34,CD117 and S-100 protein.Conclusions Both MEST and CN are uncommon renal neoplasm.Most of them run a benign clinical course.The stromal cells in MEST show smooth muscle or myofibroblastic differentiation.Areas demonstrating Miillerian features also existed in some cases.MEST and CN share overlapping histological and immunohistochemical features,and may represent spectrum of the same group of lesions.     

脑卒中急性期中医证治研究分析

通过206例脑卒中急性期病人回顾性研究分析,探讨脑卒中急性期中医证候的有关诊断与病机。结果按照传统中医证候诊断,有20％病人难于下中风诊断,认为中医中风诊断应临床症候与头颅CT扫描结果结合。中风病人肝阳暴亢型及阴虚风动型所占比例较高,其他证的肝阳上亢型或肝肾阴虚型病人要关注预防中风的治疗。中医中风病理复杂,体现在风、痰、炎、虚、气、血六端。中经络主要为小病灶,中脏腑主要为大病灶,中医治疗中风病要抓住在综合措施治疗的研究。     

咽部肌上皮瘤一例

咽部肌上皮瘤一例沈朋汪审清任国平患者女，４２岁。半个月来咽异物感，自已照镜时发现口咽部有一肿物。平时无咯血，无咽痛，无吞咽及呼吸困难。检查见右侧腭咽弓处有一约２．５ｃｍ×３．０ｃｍ×１．０ｃｍ的椭圆形实质性肿块，基底宽。肿块上起软腭游离缘，下接近舌根...     

额窦及筛窦粘液囊肿38例分析

我院自1984～1995年收治额窦、筛窦粘液囊肿38例。男18例，女20例。年龄17～79岁。平均47岁。左侧ZI例，右侧17例。粘液囊肿位于额窦11例，额筛窦12例，筛窦15例。症状以头痛、鼻塞多见，其次流涕、头昏、头胀、嗅觉减退。有症状者占52．6％（20／38）。鼻部检查多以鼻中甲肥大或息肉样变多见，或有中鼻道饱满，中鼻道息肉及嗅裂“赘生物”等。有体征者占55．3％（21／38）。眼部症状以突眼，内肌部肿胀为多见。有的伴视力减退、眼痛、流泪、复视、甚至失明。眼部症状占89.5％（10／38）。体征以眼球移位，内毗部们及肿块多见。此外，眼球…