胃大部切除术后致食道贲门粘膜撕裂症1例

1　病例介绍患者男 ,5 2岁 ,因胃十二指肠溃疡瘢痕性幽门梗阻行胃大部切除术。术中见胃窦部小弯侧有 2 cm× 2 cm溃疡 ,瘢痕波及幽门 ,幽门变形狭窄近于闭锁。术后 2 4 h病人频繁呃逆、上腹饱胀感、胃管引流不通畅。再次置管 ,病人剧烈恶心、干呕 ,胃管至食道下端贲门部时有大量鲜血自胃管引出 ,考虑为术后胃出血 ,给予止血等治疗。术后 2 8h病人呕吐约40 0 g鲜血及凝血块后休克。即补充血容量抗休克并急症行剖腹探查术。术中见胃内约 2 0 0 g条索样潴留物 ,清除后见贲门后壁有约 3cm长纵行裂口 ,深达粘膜下 ,有喷泉样活动出血。行细丝线连…     

疝环填充式无张力疝修补术在复发性腹股沟疝中的应用

传统的腹股沟疝修补术后复发率为5％～15％，复发的腹股沟疝术后再复发率升至20％～30％，为寻找合理的复发性腹股沟疝的手术方式，我们自1999年6月至2000年8月应用疝环充填式无张力疝修补术(mesh plug hernia repair，MPHR)治疗复发性腹股沟疝48例，取得了较好的效果，现总结如下。     

自体负载肿瘤抗原树突状细胞治疗大鼠甲状腺癌

Objective To investigate the immunotherapeutic effects of auto dendritic cells (DC) loaded with tumor lysates on rat transitional thyroid carcinoma. Methods After the thyroid tumor models in Wistar rats were successfully established, all rats were divided randomly into the treatment group and the control group. DC loaded with tumor lysates were injected into the tail vein of the rats in the treatment group, and the rats in control group, normal saline was injected into the tail vein. The levels of interleukin (IL)-12 and IL-8 in serum, the tumor weight and volume, and the life span of the rats were measured. Results The average tumor weight and volume, the life span, the levels of IL-12 and IL-8 in the treatment group and the control group were respectively (3. 56±0. 79) g vs (4. 97±0. 56) g, (3. 98±0. 84) cm3 vs (5.06±0.58) cm3, (36.0±3.0) days vs (28.0±3.2) days, (368.9±21.7) ng/L vs (227.7±13.4) ng/L, (218.9±19.3) ng/L vs (371.2±24. 1) ng/L. P values <0.01, <0.01, <0.05,<0.01, <0.01, respectively. Conclusion Auto DC loaded with tumor lysates can inhibit tumor growth and prolong the survival time of Wistar rats with thyroid carcinoma.     

善愈补片腹膜前间隙修补术在复发性腹股沟疝中的应用（附48例报告）

目的探讨善愈聚丙烯网片在复发性腹股沟疝中的应用。方法分析使用北京天助畅运公司的善愈补片腹膜前间隙修补48例复发性腹股沟疝的病例,观察手术时间、平均住院日、术后并发症及近期随访情况。结果48例患者全部治愈,手术时间35～95min,平均55min;术后切口轻微疼痛,有3例患者需口服药物止痛;阴囊浆液肿1例,尿潴留3例,术后住院时间平均为4．5d;术后均随访至今,无复发。结论善愈补片腹膜前间隙修补术是一种治疗复发疝的可靠方法,具有手术操作简单、安全,手术损伤小、并发症少和复发率低等优点。     

自体负载肿瘤抗原树突状细胞治疗大鼠甲状腺癌

目的 观察自体负载肿瘤抗原树突状细胞(DC)对大鼠甲状腺癌的治疗作用.方法 建立Wistar荷瘤大鼠动物模型,随机分为治疗组和对照组,治疗组静脉输入负载肿瘤抗原DC、对照组输入生理盐水,检测分析2组血清中自细胞介素(IL)-12、IL-8表达水平,以及瘤重、瘤体体积及大鼠存活.结果 治疗组与对照组瘤重、瘤体体积、存活期、IL-12及IL-8表达水平分别为:(3.56±0.79)g比(4.97±0.56)g、(3.98±0.84)cm3比(5.06±0.58)cm3、(36.0±3.0)d比(28.0±3.2)d、(368.9±21.7)ng/L比(227.7±13.4)ng/L和(218.9±19.3)ng/L比(371.2±24.1)ng/L(P值分别<0.01、<0.01、<0.05、<0.01、<0.01).结论 自体负载肿瘤抗原DC对甲状腺癌具有较好的抑瘤效应,可延长荷瘤鼠的生存期.     

开放式腹膜前间隙与完全腹膜外腹腔镜下疝修补术治疗比较分析

20世纪80年代中期以来,随着人们对腹股沟疝发病机制研究的不断深入,疝外科治疗发生了革命性的进步,尤其是近年来对腹膜前间隙的再认识,使疝修补无论是在腔镜修补领域还是在开放修补方面均进步甚世。     

自体负载肿瘤抗原树突状细胞治疗大鼠甲状腺癌

Objective To investigate the immunotherapeutic effects of auto dendritic cells (DC) loaded with tumor lysates on rat transitional thyroid carcinoma. Methods After the thyroid tumor models in Wistar rats were successfully established, all rats were divided randomly into the treatment group and the control group. DC loaded with tumor lysates were injected into the tail vein of the rats in the treatment group, and the rats in control group, normal saline was injected into the tail vein. The levels of interleukin (IL)-12 and IL-8 in serum, the tumor weight and volume, and the life span of the rats were measured. Results The average tumor weight and volume, the life span, the levels of IL-12 and IL-8 in the treatment group and the control group were respectively (3. 56±0. 79) g vs (4. 97±0. 56) g, (3. 98±0. 84) cm3 vs (5.06±0.58) cm3, (36.0±3.0) days vs (28.0±3.2) days, (368.9±21.7) ng/L vs (227.7±13.4) ng/L, (218.9±19.3) ng/L vs (371.2±24. 1) ng/L. P values <0.01, <0.01, <0.05,<0.01, <0.01, respectively. Conclusion Auto DC loaded with tumor lysates can inhibit tumor growth and prolong the survival time of Wistar rats with thyroid carcinoma.