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The SARS-CoV-2 pandemic has created a great demand for a better understanding of the spread of viruses in indoor environments. A novel measurement system consisting of one portable aerosol-emitting mannequin (emitter) and a number of portable aerosol-absorbing mannequins (recipients) was developed that can measure the spread of aerosols and droplets that potentially contain infectious viruses. The emission of the virus from a human is simulated by using tracer particles solved in water. The recipients inhale the aerosols and droplets and quantify the level of solved tracer particles in their artificial lungs simultaneously over time. The mobile system can be arranged in a large variety of spreading scenarios in indoor environments and allows for quantification of the infection probability due to airborne virus spreading. This study shows the accuracy of the new measurement system and its ability to compare aerosol reduction measures such as regular ventilation or the use of a room air purifier.  相似文献   
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Context: The administration of pharmabiotics is a promising alternative to antimicrobial drugs for the treatment and/or prevention of female urogenital infections.

Objective: To design pharmabiotic formulations including bioactive ingredients of microbial origin combined with non-microbial substances and then to evaluate the stability of the combinations during freeze-drying and storage.

Materials and methods: Different formulations including Lactobacillus gasseri CRL 1263, Lactobacillus salivarius CRL 1328, salivaricin CRL 1328 (a bacteriocin) and non-microbial compounds (lactose, inulin and ascorbic acid) were assayed, and the ingredients were freeze-dried together or separately. The formulations were stored in gelatin capsules at 4?°C for 360?d.

Results: The viability of lactobacilli was affected to different extents depending on the strains and on the formulations assayed. L. salivarius and ascorbic acid were successfully combined only after the freeze-drying process. Salivaricin activity was not detected in formulations containing L. gasseri. However, when combined with ascorbic acid, lactose, inulin or L. salivarius, the bacteriocin maintained its activity for 360?d. The selected microorganisms proved to be compatible for their inclusion in multi-strain formulations together with lactose, inulin and ascorbic acid. Salivaricin could be included only in a L. salivarius CRL 1328 single-strain formulation together with non-microbial substances.

Conclusions: This study provides new insights into the design of urogenital pharmabiotics combining beneficial lactobacilli, salivaricin CRL 1328 and compounds with different functionalities.  相似文献   
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This paper discusses the future requirements of integrated construction management systems and the need to support the management of large volumes of information on several levels. The solution proposes a combination of an efficient user interface and methods to partially automate the creation of the required information through access to stored information from past projects. The research follows the path being established for integrated construction management systems that rely on a standard representation of the industry's information requirements. By exploring the comprehensive aspects of construction planning for an integrated construction management system, the research demonstrates the usefulness of applying sound information representation structures. Through the application of case-based reasoning, the research advances the concepts of planning tools as they apply to integrated systems. The resulting prototype construction management system has the primary characteristic of assisting the user in the manipulation of information in order to generate the initial information requirements of an integrated construction management system.  相似文献   
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The corrosion properties of TiCN, TiCN – AlN, and (TiCN – AlN) – (Fe – Cr) ceramics as well as those of the individual components TiN and TiC in a 3% NaCl solution have been investigated. The kinetics and the mechanism of anode dissolution of metals and oxidation of specimens have been studied by using polarization curves, chemical and x-ray phase analyses, Auger electron spectroscopy, and scanning electron microscopy (SEM). TiCN and TiCN – AlN composites have been found to be the most corrosion-resistant. The presence of a metallic binder in the titanium carbon nitride somewhat decreases the corrosion resistance of the ceramics. On the whole, however, the ceramics developed boast a significantly higher corrosion resistance than that of structural steel.  相似文献   
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This paper presents a summary of the mechanical features and the medium term operating experience from three small horizontal axis wind energy conversion systems covering a range of 500 to 5000 Watt, intented for rural and isolated communities. These turbines have a new regulator which reduces gyroscopic loads, is easy to adjust and could be manufactured stronger and in smaller sizes than the conventional tail vanes. It is concluded that is feasible to build cheaps and reliable wind turbine generators with an acceptable efficiency employing common-use elements, but is needed a careful and optimized design.  相似文献   
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This paper presents the development of a generic framework for asset maintenance management. The framework has been presented in the form of an IDEF0 process model. The process model served to illustrate the interaction and dependencies among a diverse set of knowledge areas. In this framework, outputs from one management process become inputs to another in a subsequent hierarchy. The structure of the framework model exhibited the characteristics of flexibility and robustness. Updates in knowledge can be accommodated within the framework through incorporating new management processes and/or activities, as well as establishing new sequencing logic for these processes and/or activities. In a supporting effort to the development of the framework model, the writers have objectively reviewed the general capabilities of three commercially available software applications that are known within the asset management (AM) industry. These three applications, while encompassing a wide selection of capabilities, represent a typical selection of information technology (IT) tools and techniques that are widely used in strategic AM practices. The objective of this review is to study the operational characteristics and functionalities, and to assess the capability of software interoperability, of a representative sample of IT tools known within the AM industry.  相似文献   
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