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排序方式: 共有1621条查询结果,搜索用时 672 毫秒
1.
Anna Stasiowicz Natalia Rosiak Ewa Tykarska Maciej Kozak Jacek Jenczyk Piotr Szulc Joanna Kobus-Cisowska Kornelia Lewandowska Anita Paziska Wojciech Paziski Judyta Cielecka-Piontek 《International journal of molecular sciences》2021,22(8)
Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood–brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase). 相似文献
2.
3.
Stawarz Sylwester Witek Natalia Kucharczyk Wojciech Bakar Mohamed Stawarz Magdalena 《International Journal of Mechanics and Materials in Design》2019,15(3):585-599
International Journal of Mechanics and Materials in Design - The present work investigates the ablative and thermal properties of an epoxy resin which was modified with titanium dioxide... 相似文献
4.
D. G. Pavel’ev N. V. Demarina Yu. I. Koshurinov A. P. Vasil’ev E. S. Semenova A. E. Zhukov V. M. Ustinov 《Semiconductors》2004,38(9):1105-1110
Characteristics of ohmic InGaAs contacts in planar diodes based on semiconductor superlattices with a small-area active region
(1–10 μm2) are studied. The diodes were formed on the basis of short (18 or 30 periods) heavily doped (1018 cm−3) GaAs/AlAs superlattices with a miniband width of 24.4 meV. The reduced resistance of the ohmic contact was equal to 2×10−7 Ω cm2 at room temperature. It is shown that the properties of fabricated planar diodes make it possible to use these diodes later
on in semiconductor devices that operate in the terahertz frequency region in a wide temperature range (4–300 K).
__________
Translated from Fizika i Tekhnika Poluprovodnikov, Vol. 38, No. 9, 2004, pp. 1141–1146.
Original Russian Text Copyright ? 2004 by Pavel’ev, Demarina, Koshurinov, Vasil’ev, Semenova, Zhukov, Ustinov. 相似文献
5.
L. G. Gerchikov Yu. A. Mamaev A. V. Subashiev Yu. P. Yashin D. A. Vasil’ev V. V. Kuz’michev A. E. Zhukov E. S. Semenova A. P. Vasil’ev V. M. Ustinov 《Semiconductors》2006,40(11):1326-1332
Photoemission of polarized electrons from heterostructures based on InAlGaAs/GaAs superlattices with minimum conduction-band offsets is investigated. The comparison of the excitation energy dependence of the photoemission polarization degree with the calculated spectra make it possible to determine the polarization losses at different stages of the photoemission. A maximum polarization of P = 91% and a quantum yield of 0.14% are close to the best results obtained for photocathodes on the basis of strained semiconductor superlattices. 相似文献
6.
A. N. Gudkov V. M. Zhivun A. V. Zvonarev V. V. Kovalenko A. B. Koldobskii Yu. F. Koleganov S. V. Krivasheev V. B. Pavlovich N. S. Piven' E. V. Semenova 《Atomic Energy》1989,66(2):115-118
Translated from Atomnaya Énergiya, Vol. 66, No. 2, pp. 100–103, February, 1989. 相似文献
7.
L. Ya. Karachinsky T. Kettler N. Yu. Gordeev I. I. Novikov M. V. Maximov Yu. M. Shernyakov N. V. Kryzhanovskaya A. E. Zhukov E. S. Semenova A. P. Vasil’ev V. M. Ustinov N. N. Ledentsov A. R. Kovsh V. A. Shchukin S. S. Mikhrin A. Lochmann O. Schulz L. Reissmann D. Bimberg 《Semiconductors》2005,39(12):1415-1419
Lasers based on InAs/InGaAs quantum dots grown on metamorphic (In,Ga,Al)As layers deposited by MBE on GaAs substrates exhibited emission near 1.5 μm with a differential quantum efficiency of about 50%. The narrow-stripe lasers operate in a single transverse mode and withstand continuous current density above 20 kA cm?2 without significant degradation. A maximum continuous-wave output power of 220 mW is obtained. Neither current nor beam filamentation was observed up to the highest pumping levels. 相似文献
8.
Natalia Andronova 《Polymer》2005,46(18):6746-6755
The synthesis and characterization of degradable polymeric networks for biomedical applications was performed. Cross-linked films of poly(ε-caprolactone) (PCL) and poly(1,5-dioxepan-2-one) (PDXO) having various mole fractions of monomers and different cross-link densities were successfully prepared using 2,2′-bis-(ε-caprolactone-4-yl) propane (BCP) as cross-linking agent. Reaction parameters were carefully examined to optimise the film-forming conditions. Networks obtained were elastomeric materials, easy to cast and remove from the mould. Effect of CL content and cross-link density on the final properties of the polymer network was evaluated. High CL content or degree of cross-linking led to increase in Young's modulus and decrease in elongation at break. An increase in crystalline domains in films having a higher CL content was observed by optical microscopy. A greater thermal stability was observed in films having a high CL content. The hydrophilicity of the materials could be tailored by changing the CL content. The surface of the films became rougher with higher CL content. 相似文献
9.
A novel approach is presented to calculate the sensitivities of the scattering parameters of microwave filters obtained with the full‐wave mode‐matching (MM) technique. Using only the MM simulation of the original network, the sensitivities of the scattering parameters with respect to all designable parameters are obtained. The adjoint network method (ANM) is applied to the generalized scattering matrices of the different filter components. This guarantees good accuracy of the calculated sensitivities. The implementation details are discussed for N‐resonator ridge waveguide filters. Excellent agreement is obtained between the sensitivities calculated using ANM and those obtained using the expensive central differences. © 2006 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2006. 相似文献
10.
The authors propose an approach to solving problems of deformation of nonsymmetrically loaded shells of revolution whose boundary contours are supported in the general case at individual points. The problem is substituted by a problem with the boundary conditions of the same type around the entire contour which contain unknown parameters determined from the condition of converting to zero the displacements at the support points. Consequently, the problem is reduced to integrating systems of conventional differential equations and solving a system of algebraic equations. The solution of a problem of the stressed state of a hyperbolic shell, supported at four points at the contour, is presented.
Translated from Problemy Prochnosti, No. 8, pp. 31–35, August, 1992. 相似文献