全文获取类型
收费全文 | 2416篇 |
免费 | 96篇 |
国内免费 | 1篇 |
学科分类
工业技术 | 2513篇 |
出版年
2023年 | 14篇 |
2022年 | 13篇 |
2021年 | 47篇 |
2020年 | 38篇 |
2019年 | 41篇 |
2018年 | 56篇 |
2017年 | 52篇 |
2016年 | 66篇 |
2015年 | 60篇 |
2014年 | 77篇 |
2013年 | 120篇 |
2012年 | 118篇 |
2011年 | 116篇 |
2010年 | 97篇 |
2009年 | 106篇 |
2008年 | 114篇 |
2007年 | 97篇 |
2006年 | 88篇 |
2005年 | 56篇 |
2004年 | 57篇 |
2003年 | 47篇 |
2002年 | 64篇 |
2001年 | 44篇 |
2000年 | 26篇 |
1999年 | 45篇 |
1998年 | 154篇 |
1997年 | 95篇 |
1996年 | 54篇 |
1995年 | 50篇 |
1994年 | 45篇 |
1993年 | 49篇 |
1992年 | 30篇 |
1991年 | 9篇 |
1990年 | 26篇 |
1989年 | 16篇 |
1988年 | 24篇 |
1987年 | 27篇 |
1986年 | 18篇 |
1985年 | 26篇 |
1984年 | 26篇 |
1983年 | 20篇 |
1982年 | 19篇 |
1980年 | 14篇 |
1979年 | 15篇 |
1978年 | 11篇 |
1977年 | 15篇 |
1976年 | 15篇 |
1975年 | 15篇 |
1974年 | 12篇 |
1973年 | 14篇 |
排序方式: 共有2513条查询结果,搜索用时 168 毫秒
1.
Matteo Di Giosia Alice Soldà Markus Seeger Andrea Cantelli Fabio Arnesano Maria I. Nardella Vincenzo Mangini Francesco Valle Marco Montalti Francesco Zerbetto Stefania Rapino Matteo Calvaresi Vasilis Ntziachristos 《Advanced functional materials》2021,31(20):2101527
Fullerenes are candidates for theranostic applications because of their high photodynamic activity and intrinsic multimodal imaging contrast. However, fullerenes suffer from low solubility in aqueous media, poor biocompatibility, cell toxicity, and a tendency to aggregate. C70@lysozyme is introduced herein as a novel bioconjugate that is harmless to a cellular environment, yet is also photoactive and has excellent optical and optoacoustic contrast for tracking cellular uptake and intracellular localization. The formation, water-solubility, photoactivity, and unperturbed structure of C70@lysozyme are confirmed using UV-visible and 2D 1H, 15N NMR spectroscopy. The excellent imaging contrast of C70@lysozyme in optoacoustic and third harmonic generation microscopy is exploited to monitor its uptake in HeLa cells and lysosomal trafficking. Last, the photoactivity of C70@lysozyme and its ability to initiate cell death by means of singlet oxygen (1O2) production upon exposure to low levels of white light irradiation is demonstrated. This study introduces C70@lysozyme and other fullerene-protein conjugates as potential candidates for theranostic applications. 相似文献
2.
3.
4.
I. Belda X. Llorà E. Giralt 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2006,10(4):295-304
One of the goals of computational chemistry is the automated de novo design of bioactive molecules. Despite significant progress
in computational approaches to ligand design and efficient evaluation of binding energy, novel procedures for ligand design
are required. Evolutionary computation provides a new approach to this design issue. This paper presents an automated methodology
for computer-aided peptide design based on evolutionary algorithms. It provides an automatic tool for peptide de novo design,
based on protein surface patches defined by user. Regarding the restrictive constrains of this problem a special emphasis has been made on the design of the
evolutionary algorithms implemented. 相似文献
5.
6.
O Bernard B Chachuat A Hélias B Le Dantec B Sialve J-P Steyer L Lardon P Neveu S Lambert J Gallop M Dixon P Ratini A Quintabà S Frattesi J M Lema E Roca G Ruiz J Rodriguez A Franco P Vanrolleghem U Zaher D J W De Pauw K De Neve K Lievens D Dochaine O Schoefs H Fibrianto R Farina V Alcaraz Gonzalez V Gonzalez Alvarez P Lemaire J A Martinez F Esandi O Duclaud J F Lavigne 《Water science and technology》2005,52(1-2):457-464
The TELEMAC project brings new methodologies from the Information and Science Technologies field to the world of water treatment. TELEMAC offers an advanced remote management system which adapts to most of the anaerobic wastewater treatment plants that do not benefit from a local expert in wastewater treatment. The TELEMAC system takes advantage of new sensors to better monitor the process dynamics and to run automatic controllers that stabilise the treatment plant, meet the depollution requirements and provide a biogas quality suitable for cogeneration. If the automatic system detects a failure which cannot be solved automatically or locally by a technician, then an expert from the TELEMAC Control Centre is contacted via the internet and manages the problem. 相似文献
7.
In this work, we examine the effect of small additions of cationic quaternary ammonium salts (QAS) of different molecular weight on the rheology of an industrial ceramic suspension deflocculated with sodium polyacrylate and sodium metasilicate. The observed shear thinning behaviors obey the typical power law of fluid rheology. In order to characterize the rheological behavior of these slurries, three new parameters are introduced: a low shear rate consistency index and two transient viscosities, distant from the equilibrium, after increasing and decreasing the shear rates. These parameters vary with polyacrylate molecular weight and on additions of small quantities of QAS, which we found to be useful for decreasing the slurry viscosity. 相似文献
8.
Berrin-Wasserman Stacy; Winnick Wilma A.; Borod Joan C. 《Canadian Metallurgical Quarterly》2003,17(3):429
Does sentence generation and/or stimulus emotionality enhance verbal memory in patients with neurological impairment? This question was addressed by testing 40 patients with unilateral stroke (20 with left-brain and 20 with right-brain damage) and 20 healthy control participants for recall and recognition of 48 target words. During encoding, emotional and nonemotional words were either presented in sentences (read condition) or used to form sentences (generate condition). Both word emotionality and generative processing improved memory performance in all groups. The authors suggest that a similar influence (i.e., cognitive activation) underlies both of these memory-enhancing effects, although the putative origins of the 2 effects are quite different. Neuropsychological underpinnings and clinical implications of these phenomena are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
Sood Johanna R.; Cisek Edward; Zimmerman Joan; Zaleski Ellen H.; Fillmore Herbert H. 《Canadian Metallurgical Quarterly》2003,48(1):44
Objective: To replicate and extend P. A. Lichtenberg and colleagues' (1996) cross-disciplinary intervention to improve physical and mental health among older adults. Participants: 14 depressed older adults (6 treatment, 8 control). Setting: The short-term rehabilitation unit of an urban nursing home. Intervention: Occupational therapists were trained to treat depression using pleasant events and cognitive-behavioral therapies. Outcome Measures: Geriatric Depression Scale, the Short Form-12, and the Multi-Level Assessment Instrument: Activities of Daily Living. Results: No significant group differences were found in physical or mental health. However, more control group members (75%) than treatment group members (33%) were depressed at study completion. Conclusions: The treatment of depressive symptoms can be integrated with a nonmental health treatment modality. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
10.
GM Gazzaniga G Angelini G Pastorino E Santoro M Lucchini ML Dal Prà 《Canadian Metallurgical Quarterly》1993,78(3):271-275
Four hundred forty-six patients with Tourette Syndrome (TS) and/or their parents completed a 52-item self-report survey about vocal and motor tics, and the frequency of associated co-morbid conditions of aggression, obsessions and compulsions, attentional problems, sleep disturbance, mood disturbance, anxiety, and self-mutilative behaviours which have been frequently reported in the literature on TS. Respondents also responded to an open-ended question regarding the most disabling aspects of TS. Results were analyzed within two age groups; under 18 years of age (N = 245) and 18 years of age or older (N = 177). Tics and associated conditions were the most frequently reported disabling aspect by both age groups. Subjects under age 18, however, reported significantly more frequent problems with hyperactivity, temper control, aggressive behaviours and sleepwalking than adults with TS. 相似文献