2种贴面材料在不同粘接系统下粘接强度的对比研究

目的:比较2种不同贴面材料与3种不同的瓷贴面粘接系统粘接后的粘接强度。方法:应用3种不同的瓷贴面粘接系统(Panavia F、Variolink Veneer、RelyX Veneer),将经过相同处理的离体牙和2种不同的贴面材料(IPS e.max铸瓷和CERAM-AGE聚合瓷)粘接,每组中随机选取一半试件(n=8)37℃水浴24 h,另一半(n=8)冷热循环5 000次后测试其剪切强度,电镜下观察断裂模式。结果:IPS e.max铸瓷组和CERAMAGE聚合瓷组中Variolink Veneer粘接系统在37℃水浴24 h后或5 000次冷热循环后都表现出了最高的粘接强度(P<0.05),所有试件在经过5 000次冷热循环后的粘接强度除Panavia F组外都有明显下降。结论:对于IPS e.max铸瓷和CERAMAGE聚合瓷,Variolink Veneer粘接系统的粘接强度高于Panavia F和RelyXVeneer粘接系统。     

低氧条件下骨形态发生蛋白2对骨整合的调控

在低氧状态下,骨量丢失、骨组织再生延迟,骨组织损伤后愈合缓慢甚至不愈合,种植手术后骨整合延迟;而骨形态发生蛋白(BMP)2为成骨细胞分化的中心调控因子,无论是单一的还是组合的BMP2皆参与了软骨形成和骨形成过程。本文就低氧环境下骨组织的反应,BMP2对骨整合过程中成骨细胞和破骨细胞的影响,骨整合过程中BMP2与血管内皮生长因子间的相互作用,低氧作用于BMP2的机制等研究进展作一综述。     

Two novel variants in PLOD1 causing hydrocephalus in female newborn with kyphoscoliotic Ehlers-Danlos syndrome

The kyphoscoliotic Ehlers-Danlos syndrome (kEDS) is a rare autosomal recessive connective tissue disorder characterized by hyperextensible skin and joints, kyphoscoliosis, and severe muscle hypotonia at birth. Causal variants have been identified in PLOD1 resulting in lysyl hydroxylase deficiency responsible for kEDS. However, the detailed phenotype of kEDS during the perinatal period is still poorly recognized. Here, we describe a case of a female newborn presenting with prenatal hydrocephalus and severe hypotonia after birth with two novel compound heterozygous variants, c.2T > C (p.?) and c.1462del (p. Arg488Glyfs*9) in the PLOD1 gene. Our case suggests that in addition to the reported phenotype during the neonatal period, prenatal hydrocephalus should also be differentially diagnosed to exclude the potential of kEDS.     

Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort

Purpose

Recent genome-wide association studies have identified a number of inflammatory bowel diseases (IBD) susceptibility loci in White populations. The aim of our study was to evaluate whether these susceptibility loci also existed in a Chinese Han IBD population.

Methods

Peripheral blood DNA samples from groups of patients with Crohn’s disease (CD) (n?=?48), ulcerative colitis (UC) (n?=?49), and healthy controls (n?=?50) were genotyped for eight genes. Then, an extended analysis of the relationship between genotype and phenotype was performed.

Results

NOD2-P268S (P?=?0.025) was found to contribute susceptibility to CD in the Chinese population. IL23R-rs11805303 was detected to confer a strong protective effect against UC (P?=?0.010), whereas PTPN2-rs2542151 was significantly associated with an increased risk of UC (P?=?0.001). Further phenotype–genotype analysis revealed that P268S was associated with early age of onset (P?=?0.028), ileal disease (P?=?0.003), and enteric cavity narrowing (P?=?0.007).

Conclusions

The study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.     

Giant lymphatic malformations of the mediastinum in children: report of three cases

Lymphatic malformations are vascular malformations and consist of masses of abnormal lymphatic channels. They are uncommon in the mediastinum. We report three cases of giant mediastinum lymphatic malformations in children. One case developed two episodes of cardiopulmonary arrests, and the other two were first diagnosed and treated as pneumonia. They all recovered well after surgery. The diagnosis is rather important in lymphatic malformations. A delay in diagnosis of mediastinum lymphatic malformation increases the risk of death and prolonged clinical course. Thus, mediastinum lymphatic malformations should be kept in mind as a differential diagnosis of pneumonia and mass in the neck.     

Compromised white matter microstructural integrity after mountain climbing: evidence from diffusion tensor imaging

The aim of the present study was to investigate cerebral microstructural alterations after single short-term mountain climbing. Voxel-based morphometry (VBM) analysis of gray matter (GM) and white matter (WM) volumes and Tract-Based Spatial Statistics (TBSS) analysis of WM fractional anisotropy (FA) based on MRI images were carried out on 14 mountaineers before and after mountain climbing (6206?m). In addition, verbal and spatial 'two-back' tasks and serial reaction time task were also tested. No significant changes were detected in total and regional volumes of GM, WM, and cerebral spinal fluid after mountain climbing. Significant decreased FA values were found in the bilateral corticospinal tract, corpus callosum (anterior and posterior body, splenium), reticular formation of dorsal midbrain, left superior longitudinal fasciculus, right posterior cingulum bundles, and left middle cerebellar peduncle. In all the above regions, the radial diffusivity values tended to increase, except in the left superior longitudinal fasciculus the change was statistically significant. There were no significant changes in the two cognitive tests after mountain climbing. These findings indicate that short-term high-altitude exposure leads to disturbances mainly in cerebral WM, showing compromised fiber microstructural integrity, which may clarify the mechanisms underlining some cognitive and motor deficits tested previously.     

正常人心踝动脉硬化指数与吸烟的相关性: 539例分析

目的观察吸烟因素与动脉硬化的相关性。方法将539例31-65岁的健康男性分为吸烟组与不吸烟组。采用无创伤肢体动脉硬化检测仪分别检测两组的心踝动脉硬化指数（CAVI）。结果吸烟组CAVI阳性率显著高于不吸烟组（21．7％vs5．3％;P=0．000）。按5岁进行年龄分组,每个年龄段吸烟组CAVI值均高于同年龄段不吸烟组。（P〈0．05）。按每日吸烟量分组,吸烟量大CAVI值偏高,且差异均有统计学意义（P〈0．05）。按年龄分组,烟龄长者CAVI值增高,但差异无统计学意义（P〉0．05）。按吸烟指数分组结果显示,CAVI测量值随吸烟指数的增大而增大。结论CAVI与吸烟具有相关性。     

精神分裂症患者复发危险因素流行病学调查分析

目的：探讨影响精神分裂症复发的危险因素,为早期防治精神分裂症复发提供依据。方法采用队列研究的方法,将确诊的185例精神分裂症患者进行跟踪随访2年,收集可能影响复发的危险因素,采用单因素和多因素lo-gistic回归分析影响复发的危险因素。结果精神分裂症2年复发率为41．6％;多因素分析结果显示：偏执型（ OR＝5．501）、生活及就业压力过重（OR＝2．392）、有不良生活事件（OR＝3．452）、社会偏见歧视（OR＝3．532）、家庭支持差（OR＝4．035）、药物治疗依从性差（OR＝6．883）。结论偏执型、生活及就业压力过重、有不良生活事件、社会偏见歧视、家庭支持差、药物治疗依从性差是精神分裂症复发的独立危险因素,应针对这些因素制定干预措施。     

减重代谢手术对肥胖症患者生活质量影响的Meta分析

背景　肥胖症已经成为全球流行病,对人类的健康造成了一定的威胁。临床实践证据表明减重代谢手术（MBS）可以有效治疗肥胖症及其相关并发症,提高患者的生活质量。但MBS术后并非所有患者可取得很好的减重疗效和生活质量的提高。目的　系统评价MBS对肥胖症患者生活质量的影响。方法　计算机检索PubMed、CENTRAL、CINAHL、EMBase、中国知网（CNKI）、中国生物医学文献数据库（CBM）、万方数据知识服务平台等数据库,检索时间为建库至2019年6月。检索MBS（MBS组）及非手术治疗（非手术治疗组）对肥胖症患者生活质量影响的随机对照试验（RCT）,两名研究者按照纳入及排除标准独立筛选文献、提取资料、质量评价后,使用RevMan 5.3软件进行Meta分析。结果　共纳入7篇文献,共351例体质指数（BMI）≥27.5 kg/m2伴或不伴有2型糖尿病的肥胖症患者。Meta分析结果显示,MBS组患者生理健康评分〔加权标准差（WMD）=19.98,95%CI（11.64,28.31）,P<0.000 01〕及其中的生理功能〔WMD=42.20,95%CI（15.37,69.03）,P=0.002〕、生理职能〔WMD=27.67,95%CI（16.97,38.37）,P<0.000 01〕、躯体疼痛〔WMD=42.94,95%CI（16.60,69.29）,P=0.001〕、一般健康状况评分〔WMD=39.52,95%CI（26.60,52.45）,P<0.000 01〕高于非手术治疗组;MBS组患者心理健康评分〔WMD=13.89,95%CI（9.09,18.68）,P<0.000 01〕及其中的活力〔WMD=23.54,95%CI（17.76,29.31）,P<0.000 01〕、社会功能评分〔WMD=55.97,95%CI（45.53,66.42）,P<0.000 01〕高于非手术治疗组;MBS组患者生活质量总评分高于非手术治疗组〔标准化均数差（SMD）=1.35,95%CI（0.80,1.90）,P<0.000 01〕。结论　MBS可以在一定程度上提高肥胖症患者的生活质量,但在情感职能和精神健康方面没有改善,仍需要通过开展大样本、高质量、长期的RCT予以验证。