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Study on Syndrome Element Characteristics and Its Correlation with Coronary Angiography in 324 Patients with Coronary Heart Disease 总被引:1,自引:0,他引:1
Objective: Recently, a new traditional Chinese medicine differentiation theory "Syndrome Element(SE)" has been raised. In this study, the main syndrome element types and their correlations with the results of coronary angiography (CAG) in patients with coronary heart disease (CHD) were investigated. Methods: Epidemiology cross-sectional study method was employed and 324 patients with CHD were enrolled, and their syndrome element types as well as the CAG results were analyzed. The correlations among syndrome element types, Gensini score, and the number of abnormal branches were also analyzed based on the distribution characteristics of syndrome element and coronary angiography results in the 324 cases. Results:According to their occurrence frequency in 324 CHD patients, the top eight major heart syndrome elements were Xin (心) blood stasis (85.8%), Xin qi deficiency (79.6%), Xin heat blockage (41.1%), Xin phlegm with turbid fluid (38.0%), Xin qi stagnation (24.7%), Xin yang deficiency (18.9%), Xin yin deficiency (17.5%) and Xin cold coagulation (4.4%), respectively, which suggested that Xin blood stasis and Xin qi deficiency were the two most common syndrome elements. Also, as coronary artery Gensini score increased, the changing trend of the syndrome element was "Xin yang deficiency with blood stasis" to "Xin phlegm obstruction with heat blockage" to "Xin yin deficiency with blood stasis" to "Xin qi deficiency with blood stasis" to "Xin cold coagulation with phlegm and turbid fluid, "Xin cold coagulation with blood stasis" to "Xin deficiency of qi, yin and yang". As the number of abnormal branches increased, the syndrome element changing trend was simultaneous occurrence of cold and heat syndrome" to "Xin qi and yang deficiency with blood stasis" to "Xin retention of phlegm with turbid fluid" to "Xin cold coagulation in the heart meridian", "Xin deficiency of both qi and yin". The result of this study shows that 相似文献
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对1 022例血瘀证患者基于对应相关方法的客观量化研究 总被引:1,自引:0,他引:1
目的应用对应相关方法对不同类型和不同疾病血瘀证进行病证结合客观量化研究。方法用临床流行病学方法,病证结合研究不同血瘀证类型和不同疾病血瘀证和临床症状的关系,然后用SAS软件中的多元对应相关统计学方法进行分析。结果①初步得出不同类型血瘀证和不同疾病的血瘀证与临床症状和体征的相关性,并赋予相关系数。②得出不同类型的血瘀证和不同疾病血瘀证与临床症状和体征的差异和共同点。结论气虚血瘀证是不同类型血瘀证和不同疾病血瘀证的核心病理基础,但不同类型血瘀证和不同疾病血瘀证又有各自的特点。 相似文献
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目的:运用网络药理学及分子对接分析交泰丸治疗心律失常的作用机制。方法:通过中药系统药理学数据库与分析平台(TCMSP)与BATMAN数据库检索黄连、肉桂的活性成分和靶基因,利用GeneCards数据库检索得到与心律失常相关的靶基因,采用Cytoscape软件绘制交泰丸的“活性成分-作用靶点”网络图,采用STRING数据库构建交泰丸治疗心律失常的蛋白质-蛋白质相互作用(Protein Protein Interaction,PPI)网络图,将PPI网络图导入Cytoscape,采用DAVID数据库对药物-疾病交集靶点进行基因本体(Gene Ontology,GO)富集分析和京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG) 通路富集分析,使用Autodock Vina和Pymol进行分子对接。结果:共收集到交泰丸31个有效成分及其556个成分靶点;心律失常相关靶点2 205个;药物成分和疾病的共有靶点174个;使用Cytoscape拓扑分析得到小檗浸碱、表小檗碱、黄藤素、黄柏酮、小檗碱等20个核心成分,PPI网络得到ALB、AKT1、MAPK3、VEGFA、SRC等15个关键核心靶点。生物信息学富集分析中共获取821个GO条目,109条KEGG通路,主要涉及PI3K-AKT信号通路、Rap1信号通路、cAMP信号通路、甲状腺激素信号通路、HIF-1信号通路等。分子对接结果表明,度值排名前5的主要活性成分与核心靶点(ALB、AKT1、MAPK3、VEGFA、SRC)有较强的亲和力。结论:该研究揭示了交泰丸可能通过调控细胞代谢、降低氧化刺激、改善血管重塑等方面治疗心律失常,为后续研究交泰丸治疗心律失常提供一定的中药药理依据。 相似文献
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目的:基于网络药理学和分子对接技术,探讨强力定眩片治疗高血压的作用机制。方法:使用中药系统药理学数据库与分析平台(TCMSP)、中药分子作用机制的网络药理学在线分析工具(BATMAN-TCM)平台检索强力定眩片活性成分,使用Swiss Target Prediction数据库,对活性成分进行靶点预测。通过GeneCards、在线人类孟德尔遗传数据库(OMIM)、治疗靶点数据库(TTD)得到高血压相关靶点,整合药物靶点和疾病靶点,获取交集靶点。使用Cytoscape软件构建药物-活性成分-作用靶点-疾病网络图,筛选核心成分。利用STRING平台构建蛋白质-蛋白质相互作用(PPI)网络,筛选核心蛋白。使用MCODE对PPI网络进行蛋白聚类分析。利用DAVID数据库进行京都基因与基因组百科全书(KEGG)通路富集分析,Hiplot分析平台进行基因本体(GO)富集分析,再使用Autodock Vina和Pymol实现核心成分-核心蛋白的分子对接。结果:检索得到强力定眩片活性成分44个,作用靶点679个,疾病相关靶点2 367个,药物与疾病的交集靶点305个。KEGG分析显示,交集基因主要富集于PI3K-AKT信号通路、Ras信号通路、Rap1信号通路、钙信号通路、cAMP信号通路、HIF-1等信号通路。GO富集分析显示,交集基因主要富集于循环系统调控过程、血管管径调节、MAPK级联正向调节、血压调节等过程。分子对接结果显示,主要核心成分与核心蛋白均有较好的结合活性。结论:强力定眩片可能通过调控肾素-血管紧张素-醛固酮系统、血管平滑肌收缩、氧化应激、钙离子通道等方式,起到降低血压的功效。 相似文献
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