苦荞对大鼠实验性高脂血症的影响

对苦荞粉预防高脂肪所致大鼠高旨血症进行初步研究。将体重１６０－１８０ｇ的２７只雄性Ｗｉｓｔａｒ大鼠，随机分为对照组，高脂组，实验组，每组９只，３０ｄ后宰杀，测定总胆固醇，甘油三酯，游离脂肪酸。     

心血宝治疗原发性高血压和高脂血的临床研究

用玉瓶牌心血宝对130例病人(其中原发性高血压病人83例和高脂血病人115例)进行了为期4周的观察治疗。结果指出,心血宝的降压和降脂总有效率分别为89.16％和90.43％,收缩压和舒张压的降压幅度分别为17.09％和14.46％(P<0.01)。CH和TG的下降均值分别为2.00±0.78mmol/L和1.47±1.07mmol/L(P相似文献   

Serum lipids and anticonvulsants

The serum lipid levels of 200 epileptics (aged 20 to 40 years) undergoing long-term treatment with anticonvulsants were measured and compared with the levels of a normal population of the same age. The epileptics had higher serum lipid levels (especially of apolipoprotein B and HDL-cholesterol) but no higher incidence of hyperlipemias. A correlation between LDL-cholesterol and vitamin E has been found in epileptics, but it was not as significant as in normals. In male epileptics, positive correlations between the average daily dose of anticonvulsants (especially of those with a well-known enzyme-inducing effect) and triglycerides, cholesterol and LDL-cholesterol were found; in females there were no significant correlations.     

杨牧祥治疗高脂血症经验

高脂血症属中医痰浊、瘀血证范畴,与肝脾肾的功能失调相关,因脾失健运,痰瘀互结导致。杨老提出"从痰瘀论治",化痰降浊、活血化瘀治其标,健脾益气、强本清源治其本。每用皆获疗效。     

Adriamycin causes hyperlipemia as a consequence of nephrotoxicity

Adriamycin induced hyperlipemia: its features and mechanism(s) in rats were investigated. Massive hyperlipemia occurred 14–21 days after a single dose of adriamycin (7.5 mg/kg i.v.). All lipoprotein fractions were affected. Mild but significant changes in tissues were observed (liver and intestine triglycerides and kidney phospholipids were reduced). Lipid synthesis and secretion was decreased, as shown by the Triton WR1339 test 7 days after treatment, but subsequently returned to normal. Mitochondrial oxidation of long-chain fatty acids was markedly reduced in kidney, and a slight reduction was also observed in heart. Lipoprotein lipase activity was reduced in adipose tissue. These results suggest that adriamycin hyperlipemia is due to reduced lipid storage and utilization. Carnitine did not counteract hyperlipemia and proteinuria after adriamycin. Analogies to hyperlipemia following puromycin aminonucleoside-induced nephrotoxicity are discussed.     

山楂丹参合用调节血脂作用的实验研究

目的探讨山楂、丹参合用对血脂的调节作用.方法采用高脂饲料动物造模,空白组8只给予普通饲料喂养(空白对照组);高脂饲料组42只,饲以高脂饲料;将造模组随机分为5组,分别为模型组,舒降之组,山楂组,丹参组,山楂、丹参合用组。第14天后分别测定血清TC、TG、HDL-C、LDL-C含量;血浆SOD活性。结果山楂、丹参合用能降低TC、TG、LDL,升高HDL含量,有明显降低SOD活性作用.结论山楂、丹参合用有调节血脂作用。     

大豆异黄酮及其山楂复方对高脂血症大鼠血栓形成的影响

目的:探讨大豆异黄酮及其与山楂复方对高脂血症大鼠血栓形成的影响。方法:大鼠喂饲高脂饲料,同时灌服药物10周,试验结束时取血浆用于相关生化指标的测定。结果:高脂血症组大鼠ET-1、TXB2/6-keto-PGF1α、D-dimer和FDP均明显高于正常组。经大豆异黄酮和大豆异黄酮 山楂复方治疗ET-1、TXB2/6-keto-PGF1α、D-dimer和FDP不同程度低于模型组,NO水平高于模型组。结论:大豆异黄酮及其与山楂的复方具有抗高脂血症血栓形成作用,对高脂诱导的内皮功能有一定改善和修复作用。     

丹蛭降糖胶囊对2型糖尿病合并高脂血症患者纤维蛋白原水平的影响

目的进一步观察丹蛭降糖胶囊对2型糖尿病合并高脂血症患者纤维蛋白原水平的影响.方法采用丹蛭降糖胶囊对32例2型糖尿病患者的纤维蛋白原水平学指标进行了治疗前后的观察测定.结果丹蛭降糖胶囊不仅可显著改善2型糖尿病患者的血糖、血脂等,还可显著改善患者血浆纤维蛋白原水平.结论提示丹蛭降糖胶囊可以改善机体的纤维蛋白原水平,防止并发症的发生和发展.     

当归芍药散防治高脂血症的实验研究

【目的】观察当归芍药散对高脂血症的防治作用并初步探讨其作用机制。【方法】采用饲养法建立家兔高脂血症模型，观察当归芍药散对高脂家兔的血清脂质、肝脏脂质的影响。【结果】当归芍药散可以显著降低高脂血症模型家兔血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL—C）、载脂蛋白B100（ApoB100）水平，升高高密度脂蛋白（HDL—C）和载脂蛋白AI（ApoAI）水平，降低肝组织TC、TG，抑制脂质在肝脏的沉积。【结论】当归芍药散防治高脂血症的作用机制可能与以上因素密切相关。     

某高校13年来高血压、高脂血症与糖尿病的流行趋势及其相关性调查

目的了解高校高血压的人群患病率、高血压脂代谢异常与发生糖尿病的关系。方法通过回顾性调查自1989年以来记录的高血压、糖尿病防治情况及历年全院健康体检记录的血脂检查情况进行统计分析。结果我院高血压的患病率由1991年的10·74%升至2003年的14·68%(P<0·05);≥60岁人群的患病率由1991年的28·58%升至2003年的40·14%(P<0·05),且各年份≥60岁人群的患病率均明显高于全院教职工总的患病率(P<0·01),≥60岁的高血压患者占病人总数的比例由1991年的57·58%升至2003年的73·50%(P<0·05);糖尿病患者51·36%同时有高血压;高血压伴血脂异常和糖尿病者为18·56%。结论高校教职工特别是≥60岁人群高血压患病率有逐年增高的趋势,高血压并血脂异常及糖尿病的可能原因为胰岛素抵抗及高胰岛素血症。在降压治疗的同时应注意调脂治疗并预防高血压并发糖尿病的发生。