黄芪注射液治疗慢性肾小球肾炎的观察

目的黄芪注射液治疗慢性肾小球肾炎降尿蛋白,探讨降蛋白尿作用与患者T细胞亚群。某些细胞因子、免疫功能调节变化的关系。方法30例慢性肾小球肾炎患者静脉滴注黄芪注射液（含黄芪2g/ml）40ml/d,21d为一个疗程,测定24h尿蛋白定量,血CD3、CD4、CD8百分率,CD4/CD8比例,血SIL-2R、SIL-6R水平。结果 治疗后24h尿蛋白定量明显下降,从2328.10mg/24h降至1017.21mg/24h（P<0.01）。CD4明显下降从45.54到40.77（P<0.05）,CD8明显上升从25.33升至27.74（P<0.01）,CD4/CD8明显下降从2.56降至1.70,可溶性白介素2受体（SIL-2R）和可溶性白介素6受体（SIL-6R）亦明显下降,分别从673.08ng/L、43.22ng/L降到548.95ng/L、36.18ng/L（P<0.05）。结论 黄芪对细胞免疫有调节作用并能有效降低某些病理类型慢性肾小球肾炎的尿蛋白。     

LONG-TERM ADMINISTRATION OF RADIX TRIPTERYGII GLYCOSIDE IN A VARIETY OF GLOMERULONEPHRITIS

R啨ｓｕｍ啨　　 Objectif　 valuerl effetth啨ｒａｐｅｕｔｉｑｕｅｅｔｌｅｓｒ啨ａｃｔｉｏｎｓｉｎｄ啨ｓｉｒａｂｌｅｓｄｕｇｌｕｃｏｓｉｄｅｄｅｌａｒａｃｉｎｅｄｅＴｒｙｐｔｅｒｙｇｉｕｍＷｉｌｆｏｒｄｉｉｄａｎｓｌｅｔｒａｉｔｅｍｅｎｔ劋ｌｏｎｇｔｅｒｍ     

尿毒症高脂血症的治疗

尿毒症患者脂质代谢紊乱尿毒症的原发肾脏疾病虽不同,但发展到肾衰竭阶段,原有肾脏疾病对脂代谢似乎无多大影响,如慢性肾小球肾炎引起尿毒症患者的脂代谢变化与肾切除者相同,与多囊     

糖尿病肾的代谢改变与肾小球硬化

糖尿病性肾小球硬化系糖尿病的重要并发症,也是目前糖尿病死亡的主要原因之一。据估计,胰岛素依赖型糖尿病患者死于尿毒症占80%;心肌梗塞症占10%;其它占10%。因此,糖尿病肾小球硬化已引起国内外学者的普遍重视。本文就糖尿病时的肾代谢     

甲状旁腺激素与尿毒症

尿毒症病人表现全身各器官功能紊乱,呈现神经、消化、血液、循环、呼吸、泌尿等系统的多种症状和体征。这些症状和体征常被归咎于尿毒素。尿毒素究竟是什么?近几年来,由于使用现代化仪器,如气—液色谱、质谱法等,已从尿毒症血液分离到200多种代谢产物,其中100多种在尿毒症时特有或比正常值高。现认为主要是一些蛋白质的代谢产物,其中尤以胍类如甲基胍、胍基琥珀酸及一些未知结构的中分子物质的积聚尤为人们所注意,而尿素,肌酐、     

EFFECT OF LOW PROTEIN DIE'T ON WHOLE BODY NITROGEN METABOLISM IN PATIENTS WITH CHRONIC RENAL FAILURE

isN-glycine was administered orally as a tracer t0 3 patients with chronic renal failure (CRF) in the study of total body protein metabolism during the course of diet therapy. Five healthy subjects with matched age and sex served as controls. Patients on a diet providing l.2 g protein/kg/day had significantly low total nitrogen flux (Q), rates of total body pro- tein synthesis (S), catabolism (C) and S/Q, as com' pared with the controls. A reduction in daily protein intake t0 0.6 g/kg/day resulted in marked increase in all these parameters, approaching those of the con- trols. In normal subjects, low protein intake did not affect the total body protein turnover signfiicantly. The results suggest that the adaptive response to res- triction of protein intake is an efficient utilization of nitrogen entering the metabolic pool for anabolic purposes. This response becomes manifest and essen- tialin patients with CRF and forms the basis for low protein diet therapy.     

肾小球系膜细胞膜离子通道的研究进展

通过对近几年来膜片钳技术研究肾小球系膜细胞膜离子通道的回顾 ,阐述了系膜细胞膜离子通道的种类、特性及其调节的电生理机制 ,并介绍了系膜细胞膜离子通道在介导肾脏疾病 ,特别是糖尿病肾病中的重要作用。此外 ,还讨论了血管紧张素转换酶抑制剂和钙通道阻滞剂的肾脏保护作用与系膜细胞膜离子通道的关系。     

PATTERN OF SERUM TRYPTOPHAN IN CHRONIC RENAL FAILURE

Data on serum total (Trp) and free (fTrp) and bound (bTrp) tryptophan concentrations in patients with chronic renal failure were analysed. The results revealed marked decrease of serum Trp and bTrp, increase of fTrp concentrations and negative correlation between serum creatinine and bTrp/albumin ratio. The mechanism leading to these alterations is not clear. Increased serum fTrp concentration may play a role in causing uremic syndrome.     

成人型多囊肾病

成人型多囊肾是一种临床常见的遗传性肾脏疾病。病人多在30～40岁出现腰腹部胀痛、血尿、高血压、尿路感染及腹块等症状。病程进展较缓慢,常在四十多岁时引起终末期肾衰,最终死于尿毒症。由于本病可在任何年龄中发生,故有人提出了常染色体显性遗传多囊肾的名称,以此与常染色体隐性遗传的所谓婴儿型多囊肾相区别,而事实上,后者也偶可在成人