中、日、韩三国中医药SCI论文计量分析

以SCIE平台为数据来源,从发文量、被引情况、语种、期刊、学科、机构、国际合作等方面,对SCIE平台收录的1996—2015年中国、日本、韩国发表的中医药领域论文进行计量分析。我国SCI论文的发文总量、被引总量大幅领先日本、韩国,篇均被引次数近年来与日本、韩国持平。超过97%的论文以英语发表。发文量Top 10期刊影响因子主要分布在1~3分左右,以替代医学、药理/药学、化学领域期刊为主。药理学/药剂学、化学、生物化学/分子生物学是中医药SCI论文发文量最大的领域,其发文量、被引次数高于替代医学。中国科学院系统、综合性大学是中医药科研的重要力量,且论文篇均被引次数普遍高于中医药院校。中国的国际合作率低于日本、韩国。国际合作论文的被引次数高于非国际合作论文的被引次数。我国中医药科研水平与日本、韩国接近,但在规模上更具优势。中药学是中医药研究领域的优势学科。与中国科学院系统、综合性大学相比,我国中医药院校的科研影响力需要进一步提高。我国中医药科研国际合作率偏低,需要加强中医药国际科研合作实力。     

重复经颅磁刺激对截瘫后脊髓兴奋性作用的实验研究

目的观察重复经颅磁刺激对脊髓损伤大鼠脊髓兴奋性的影响并探讨其机制。方法利用重物撞击法制备成年SD大鼠T10脊髓损伤模型，造模8周后脊髓损伤磁刺激组给予0．5Hz阈上强度经颅定位磁刺激，每天500个脉冲，共4周。另设脊髓损伤组及正常对照组。各组大鼠不同时点行后肢F波检测，观察F与M波幅比值；免疫组化法观察5-羟色胺（5-HT）在脊髓损伤区头尾端的变化情况。结果脊髓损伤后8周F波幅增高，M波幅恒定，与正常对照组比较，F／M波幅比值明显升高（P〈0．01）；磁刺激后，F／M波幅比值降低，与脊髓损伤组比较有非常显著性差异（P〈0．01）；脊髓损伤8周时，损伤头、尾端5-HT密度明显降低（P〈0．01）；磁刺激后，损伤头、尾端表达均明显升高（P〈0．01）。结论重复经颅磁刺激可以降低慢性下胸段脊髓不全损伤大鼠脊髓兴奋性，其机制可能与通过残存5-HT能下行传导束增加递质分泌，改善脊髓上位中枢对脊髓损伤尾端的控制有关。     

Vertebral Body Infarct and Ventral Cauda Equina Enhancement: Two Confirmatory Findings of Acute Spinal Cord Infarct

Two valuable confirmatory MRI findings of acute spinal cord infarct are highlighted and discussed: concomitant vertebral body infarct and ventral cauda equina nerve root enhancement.     

Novel multifunctional polyethylene glycol-transactivating-transduction protein-modified liposomes cross the blood-spinal cord barrier after spinal cord injury

The blood-spinal cord barrier (BSCB) prevents many macromolecular agents from passing through to reach sites of injury in the spinal cord. This study evaluated the ability of a novel multifunctional liposome modified with polyethylene glycol (PEG) and transactivating-transduction protein (TAT) containing an iron core to cross the BSCB using a rat model of spinal cord injury. Rats were examined daily for a period of three days after spinal cord injury and injection of either the multifunctional modified liposome or control formulations using a 3.0 T magnetic resonance imaging spectrometer. A low signal was observed in the T2-weighted images. Prussian blue staining and flame atomic absorption spectrophotometry revealed that significantly more iron accumulated around the lesion site in the experimental group than the control groups (P?<?0.05). The findings from this study suggest that this multifunctional liposome carrier can cross the BSCB to accumulate around the lesion site.     

Effects of wheelchair training on [Vdot]O2 kinetics in the participants with spinal-cord injury

Purpose.?We tested the hypothesis that, in eight participants (seven males, one female; 46.5 ± 8.3 years) with spinal-cord injury (complete lesions, T7-L1), the effects of exercise training on pulmonary O₂ uptake ([Vdot]O₂) on- and off- kinetics would appear early in this pilot study.

Methods.?The subjects underwent the wheelchair-training program (3 day/w, 30 min/day, and 50% HRreserve), and were evaluated before training (“time 0”, T0), and after 7 (T7), 15 (T15), 30 (T30), and 60 (T60) days of training. Breath-by-breath peak [Vdot]O₂ was determined during the incremental exercise until their exhaustion. At another day following the incremental exercise, the subjects performed three repetitions of a constant exercise at 50% peak [Vdot]O₂ workload so that [Vdot]O₂ could be determined for both on- and off-kinetics.

Results and conclusion.?Peak [Vdot]O₂ showed a tendency to increase with training; the increases became significant at T30. The time constants (τ₂) during “phase II” of the [Vdot]O₂ on-kinetics were 62.4 ± 13.0 (s) (T0), 51.2 ± 8.7 (T7), 46.1 ± 7.4 (T15), 45.0 ± 7.2 (T30), and 43.4 ± 6.4 (T60); a significant difference compared to T0 was observed from T7 onward. The same pattern of change as a function of training was described for the [Vdot]O₂ off-kinetics. It is concluded that in SCI participants, the acceleration of [Vdot]O₂ kinetics at the onset of exercise was observed over a short term.     

国内学者眼科领域系统评价和Meta分析在SCI期刊的发表情况

目的 统计分析目前国内学者在SCI期刊发表的眼科领域系统评价和Meta分析论文情况，为今后发表此类研究提供参考。设计 描述性研究。研究对象 在PubMed、EMBASE及Cochrane library三大数据库中收录的所有眼科领域的系统评价和Meta分析论文。方法 系统检索PubMed、EMBASE及Cochrane library三大数据库。检索时，限定研究对象为人类，语言为英语，检索时间截止到2017年1月30日。通过阅读标题、摘要及全文，排除重复及不相关研究，将最终符合条件的研究按作者来源、发表年限、疾病类型等进行归类分析。主要指标 作者来源、发表年限、疾病类型。 结果 三大数据库共检索到10 551条题录（PubMed 4214，EMBASE 6155，Cochrane library 182）。排除重复及不相关研究后，最终符合条件的系统评价和Meta分析442篇。此类研究最早发表于2004年，按年发表量排名，前三名分别是：2015（100篇，22.62%）、2014（91篇，20.59%）、2016（90篇，20.36%）。共有来自52个城市的作者参与发表过此类研究，前三名城市分别是：上海（95篇，21.49%）、北京（45篇，10.18%）、广州（38篇，8.60%）。共有126种杂志发表此类研究，前三名杂志分别是：PLoS One (79篇，17.87%)、Molecular Vision（16篇，3.62%）、BMC Ophthalmology（15篇，3.39%）。研究内容以视网膜疾病最多，前三名疾病分别是：视网膜疾病（168篇，38.01%）、青光眼（95篇，21.49%）、屈光手术（47篇，10.63%）。定性系统评价17篇（3.85%），Meta分析425篇（96.15%）。在Meta分析中干预性研究177篇，观察性研究248篇，后者以基因相关研究（137篇）、危险因素（84篇）为主。结论 国内学者在眼科领域系统评价发表量逐年增多，作者主要集中于国内大城市，尤其是上海和北京，研究热点主要是视网膜疾病、青光眼，非干预性研究发表量已超越干预性研究，其中以基因相关研究及危险因素研究为主。