医学博士生英文SCI论文写作课程的开设

在医学院校博士生中开设英文SCI论文写作课十分必要。第三军医大学在该课的课程设置上以学习者的需求为导向,确立了符合学习者实际情况的课程目标、课程内容、教学模式等。同时,采取了＂以写促学＂的课堂教学模式和＂课堂教学＂与＂课外讲座＂相结合的立体化研究生英文SCI论文写作课程体系,为医学院校优化该课程的设置提供了借鉴。     

SCI分析工具在抑郁症研究中的应用

以Web of Science网络数据库为数据来源,对1999/2008科学引文索引扩展版（SCI-E）收录的抑郁症研究论文进行统计分析,得出抑郁症研究的研究进展以及抑郁症研究的核心著者、核心期刊.     

2003-2007年SCI收录SARS相关文献的分析研究

利用PubMed数据库检索2003—2007年SCI收录的SARS相关文献,对其年度文献数量变化、国家和地区分布、主要研究机构等进行分析研究,探讨SARS文献的分布规律、研究现状和发展趋势,以期为我国的SARS相关研究工作提供参考。     

脊髓损伤患者泌尿系感染细菌学特征及对策

本文分析脊髓损伤患者泌尿系感染的病原菌构成及耐药状况。对 1998年 1月至 1999年 6月住院SCI患者中段尿进行培养、病原菌鉴定及药敏试验。结果显示 4 56株病原菌中 G-杆菌与 G 球菌之比为 9.36∶1。G-杆菌耐药率依次是铜绿假单胞菌、阴沟肠杆菌和大肠杆菌。金葡菌的耐药率 6 2 %。根据 SCI患者泌尿系感染病原菌特点及耐药机制的不断变迁 ,合理选择抗菌药物并综合运用其它治疗手段控制感染十分重要。     

Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia

We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy.     

The crossed phrenic phenomenon

The cervical spine is the most common site of traumatic vertebral column injuries. Respiratory insufficien-cy constitutes a significant proportion of the morbidity burden and is the most common cause of mortality in these patients. In seeking to enhance our capacity to treat specifically the respiratory dysfunction follow-ing spinal cord injury, investigators have studied the "crossed phrenic phenomenon", wherein contraction of a hemidiaphragm paralyzed by a complete hemisection of the ipsilateral cervical spinal cord above the phrenic nucleus can be induced by respiratory stressors and recovers spontaneously over time. Strength-ening of latent contralateral projections to the phrenic nucleus and sprouting of new descending axons have been proposed as mechanisms contributing to the observed recovery. We have recently demonstrat-ed recovery of spontaneous crossed phrenic activity occurring over minutes to hours in C1-hemisected unanesthetized decerebrate rats. The specific neurochemical and molecular pathways underlying crossed phrenic activity following injury require further clarification. A thorough understanding of these is nec-essary in order to develop targeted therapies for respiratory neurorehabilitation following spinal trauma. Animal studies provide preliminary evidence for the utility of neuropharmacological manipulation of sero-tonergic and adenosinergic pathways, nerve grafts, olfactory ensheathing cells, intraspinal microstimulation and a possible role for dorsal rhizotomy in recovering phrenic activity following spinal cord injury.     

Evaluation of manual wheelchairs by individuals with spinal cord injuries

Purpose.?The aim of this study was to investigate how adults with spinal cord injury assess their satisfaction regarding various aspects and use of their manual wheelchair.

Method.?The Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST 2.0) together with seven additional questions was sent to 205 adults with SCI.

Results.?One hundred and twenty-four responses were available. The QUEST 2.0 showed a high level of satisfaction with manual wheelchair properties. However, the respondents were less satisfied with the services offered. Ease of use and comfort were identified as most important. Eighty-nine percent of the respondents rated their level of satisfaction as ‘quite satisfied’ or ‘very satisfied’ in ease of using a manual wheelchair compared with 68% of the respondents that were ‘quite satisfied’ or ‘very satisfied’ with the level of comfort. A greater satisfaction of ease in propulsion indoors compared with sitting comfort in various activities was found.

Conclusions.?A discrepancy was shown between users not being as satisfied with comfort in sitting in various activities as opposed to satisfaction with propulsion. This indicates the need for increased knowledge and developments concerning individual solutions, incorporating comfort as well as ease of use of a manual wheelchair.     

移植胚鼠神经干细胞对大鼠脊髓损伤后红核神经元损伤的影响

目的研究神经干细胞(NSCs)移植对大鼠脊髓损伤(SCI)后红核神经元的作用。方法5-溴脱氧尿嘧啶核苷(BrdU)法标记处于对数生长期的NSCs,采用电控脊髓损伤打击装置制作大鼠脊髓损伤模型。实验分为3组:NSCs组、SCI组和假手术组(Sham组)。SCI后3 d进行NSCs移植,用免疫组化法观察移植细胞的存活及迁移情况,用辣根过氧化物酶(HRP)逆行示踪技术标记红核神经元,并用四甲基联苯胺(TMB)呈色反应显示红核脊髓束神经元的存活情况,用行为学(BBB)评分法观察大鼠瘫痪肢体的恢复情况。结果在损伤脊髓区域可检测到BrdU标记的阳性NSCs,中脑HRP标记红核神经元数目明显多于SCI组(P<0.01),BBB评分亦明显高于SCI组(P<0.01)。结论体外培养的胚胎大鼠NSCs在移植到脊髓损伤区域后可存活和迁移,对SCI后中脑红核神经元具有保护作用,从而促进了大鼠肢体功能的恢复。