Development of a Sexual Needs Rehabilitation Framework in Women Post–Spinal Cord Injury: A Study From Iran

Objective

To develop a sexual needs rehabilitation framework in women after spinal cord injury (SCI).

Mobility Device Quality Affects Participation Outcomes for People With Disabilities: A Structural Equation Modeling Analysis

Objective

To test the effect that indicators of mobility device quality have on participation outcomes in community-dwelling adults with spinal cord injury, traumatic brain injury, and stroke by using structural equation modeling.

Identification of pseudobulbar affect symptoms in the nursing home setting: Development and assessment of a screening tool

Pseudobulbar Affect (PBA) is a neurologic condition characterized by involuntary outbursts of crying and/or laughing disproportionate to patient mood or social context. Although an estimated 9% of nursing home residents have symptoms suggestive of PBA, they are not routinely screened. Our goal was to develop an electronic screening tool based upon characteristics common to nursing home residents with PBA identified through medical record data. Nursing home residents with PBA treated with dextromethorphan hydrobromide/quinidine sulfate (n = 140) were compared to age-, gender-, and dementia-diagnosis-matched controls without PBA or treatment (n = 140). Comparative categories included diagnoses, medication use and symptom documentation. Using a multivariable regression and best decision rule analysis, we found PBA in nursing home residents was associated with chart documentation of uncontrollable crying, presence of a neurologic disorder (e.g., Parkinson's disease), or by the documented presence of at least 2 of the following: stroke, severe cognitive impairment, and schizophrenia. Based on these risk factors, an electronic screening tool was created.     

Cervical spinal cord injury： tailoring clinical trial endpoints to reflect meaningful functional improvements

Cervical spinal cord injury （SCI） results in partial to full paralysis of the upper and lower extrem- ities. Traditional primary endpoints for acute SCI clinical trials are too broad to assess functional recovery in cervical subjects, raising the possibility of false positive outcomes in trials for cervical SCI. Endpoints focused on the recovery of hand and arm control （e.g., upper extremity motor score, motor level change） show the most potential for use as primary outcomes in upcoming trials of cervical SCI. As the field moves forward, the most reliable way to ensure meaningful clinical testing in cervical subjects may be the development of a composite primary endpoint that measures both neurological recovery and functional improvement.     

挤压伤脊髓腹角神经元NT-3表达的变化

运用免疫组化ＡＢＣ法探讨了脊髓挤压伤后不同时间腹角ＮＴ－３的表达变化。结果：对照组可见ＮＴ－３免疫反应阳性细胞分布于腹角的大神经元和少量小神经元,胞核、胞浆均染色。此外,亦见少量阳性胶质细胞。     

客观看待利用SCI进行科研成果评价

介绍了SCI数据库和利用其评价科研的优缺点，提供了合理的建议。     

脊髓损伤后导尿管留置时间对膀胱功能的影响

目的:探讨脊髓损伤后导尿管留置时间对患者膀胱功能的影响。方法:对70例脊髓损伤患者进行3个月的无菌间歇导尿,观察与比较导尿管留置时间不同患者膀胱容量的改变与泌尿系感染率。结果:脊髓损伤后导尿管留置时间大于4周的患者,其泌尿系感染率为95%,膀胱容量平均为295±73ml;导尿管留置不足4周患者的泌尿系感染率为35%,膀胱容量平均为455±103ml。两组间有显著性差异(P<0.05)。结论:脊髓损伤后,应尽可能早期拔除导尿管,进行间歇导尿,有利于患者膀胱功能的恢复及减少泌尿系感染的发生率。     

中韩针刺镇痛研究的文献计量学分析

利用SCI和Medline两个数据库,对其中收录的中韩两国作者发表的针刺镇痛文献,分别从文献数量、载文刊物影响因子、文献被引用次数、作者的文献产出量、机构间的合作、文献类型、采用RCT的强弱以及结论的倾向性等方面进行了统计比较,发现:①中国作者发表的文献量大于韩国,且发表时间早于韩国,但文献量的变化波动较大,而韩国作者的文献量变化却较为平稳;②中国作者的文献影响悬殊,韩国作者的文献影响较均衡;③中国作者文献产出量较高,韩国研究机构间的合作较多;④韩国作者在研究中基本保持有组织的怀疑态度,而中国作者有的则缺乏这样的态度。这些统计结果表明,中国针刺镇痛研究在走下坡路,而韩国的这一研究正在兴起;中国针刺镇痛研究的整体思路和特征对其长远发展是不利的。     

胚胎干细胞定向分化运动神经元的基因调控

本文着重就胚胎干细胞 (ESCs)定向诱导分化为脊髓运动神经元过程中两个重要阶段及相关基因的表达调控进行综述。运动神经元分化的基因调控研究将有利于阐明其发育和分化的模式 ,为其应用于脊髓损伤修复和运动神经元退行性疾病的替代治疗提供理论依据