Coagulation Profile in Persons with Long-standing Spinal Cord Injury

ABSTRACT

Acute spinal cord injury (SCI) is associated with a marked propensity to thromboembolism and a variety of coagulation abnormalities. However, data on blood coagulation profiles in patients with uncomplicated long-standing SCI are limited. These data were studied here. Eight men with uncomplicated chronic SCI and nine able-bodied normal men were studied. Plasma activities and/or antigen concentrations of high molecular weight kininogen (HMWK) and of factors XII, XI, IX, VIII, VII, X, V, II and XIII as well as von Willebrand factor (vWF), fibrinogen and fibronectin were measured by appropriate functional and or immunological assays. The SCI group exhibited normal values for factors XII, IX, VIII, vWF, VII, X and V as well as HMWK, vWF and fibronectin concentration. However, they showed slight reductions in plasma factor XI activity, factor XIII antigen concentration and modest increases in fibrinogen and factor II concentrations. No correlation was found between the parameters studied and either the duration or the level of injury.

In conclusion, in contrast to acute SCI, the coagulation profile in uncomplicated chronic SCI is noted to be largely normal with only a few minor alterations of questionable clinical significance. (J Am Paraplegia Soc; 17: 133–135)     

Aquatic,deep water peak VO2 testing for individuals with spinal cord injury

Objective: To determine the reliability of peak VO₂ testing for individuals with spinal cord injury (SCI) in deep water and on land; and to examine the relationship between these two testing conditions.

Design: Reliability study.

Setting: Comprehensive rehabilitation center in Baltimore, MD, USA.

Participants: 17 participants (13 men, 4 women) with motor complete and incomplete SCI. Participants were randomized into either aquatic or arm cycle ergometer first measurements.

Intervention: Pilot study to assess peak VO₂.

Outcome measures: Peak VO₂ measured with metabolic cart in supported deep water with the addition of Aquatrainer® connection, and on land with arm cycle ergometer. Two trials were conducted for each condition with 48?h separating each test.

Results: Peak oxygen consumption reliability was statistically significant for both conditions, aquatic (r?=?0.93, P?<?0.001) and arm cycle ergometry (r?=?0.96, P?<?0.001). Additionally, aquatic and arm cycle peak VO₂ correlation existed (r?=?0.72, P?<?0.001). For these 17 participants, lower extremity motor score influenced supported, deep water peak VO₂, B?=?0.57, P?<?0.02, whereas age, sex, and weight did not impact deep water or ergometer values.

Conclusion: Determining peak VO₂ for individuals with SCI is highly reproducible for arm cycle ergometry and in deep water assessment. Additionally, aquatic, deep water peak VO₂ testing is valid when compared to arm cycle ergometry. Although the peak VO₂ relationship between deep water and arm cycle ergometry is high, variance in the two conditions does exist. Therefore, it is important to assess peak VO₂ via the same exercise modality utilized in the treatment intervention.     

早期康复治疗对脊髓损伤患者日常生活活动能力的影响

目的 探讨脊髓损伤（SCI）后早期康复对患者日常生活活动能力（ADL）的影响。方法 对50例SCI患者进行早期康复治疗，观察ADL的改善情况。结果 经2个月康复治疗，患者的Barthel指数及功能独立性测评（FIM）评分与治疗前有显著性差异（P〈0．05），ADL提高。结论 早期康复训练可有效提高SCI患者的ADI。     

国内外哮喘临床研究现状比较——基于SCI论文的计量分析

文章采用文献计量学方法,对1997~2009年哮喘临床研究领域发表在SCI上的研究论文进行了统计和数据挖掘,分别从论文发表的年代?地区?机构?学科和作者分布进行了分析,并就国内外的研究状况进行了比较,通过对被SCI收录的哮喘方面的研究论文的数量及引用情况?期刊分布和学科分布等因素的统计分析,揭示出国内外哮喘研究的现状和差距,以期为国内的哮喘研究提供参考?     

1999-2008年SCI收录广东省与北京、上海等五省市医学论文比较

为了解广东省内医疗机构的科研发展情况,以SCI数据库为统计源,统计广东省与北京市、上海市、江苏省、浙江省、山东省六省市的医学院校、医学研究所、医院等医疗机构1999-2008年10年间被SCI收录的医学论文,并分析和对比了这些论文每年的被引频次和学科构成.     

全脊髓毁损术治疗截瘫后神经痛的临床研究

目的 探讨全脊髓毁损术对治疗脊髓损伤截瘫后顽固性神经痛方法的可行性、安全性和有效性.方法 14例脊髓损伤后神经痛患者经过磁共振检查和体格检查确定损伤平面,在其上1~2个节段,应用CT引导定位经椎板穿刺至脊髓进行持续射频热凝治疗.结果 所有患者均毁损成功,除1例在治疗后3年疼痛复发进行二次脊髓毁损治疗后疼痛消失外,其余患者均无疼痛发生,其有效率为92.9%.结论 全脊髓毁损对于治疗脊髓损伤截瘫后神经痛可做到安全,有效和准确具有临床实用价值.     

高压氧与带血供周围神经移植修复鼠脊髓损伤的研究

目的探索联合应用高压氧与带血供周围神经移植修复脊髓损伤的作用。方法将40只雌性Wistar成年鼠分为A、B两组,A组为单纯带血供的正中神经移植修复脊髓损伤;B组为带血供的正中神经移植后给予高压氧治疗。结果在组织学、神经传导速度及移植神经内再生轴突形态计量分析诸方面,效果明显好于A组。结论带血供周围神经是修复脊髓损伤较为理想的移植材料,高血氧能够提高带血供周围神经移植修复脊髓损伤的能力。