A Novel Feature Extraction Method with Feature Selection to Identify Golgi-Resident Protein Types from Imbalanced Data

The Golgi Apparatus (GA) is a major collection and dispatch station for numerous proteins destined for secretion, plasma membranes and lysosomes. The dysfunction of GA proteins can result in neurodegenerative diseases. Therefore, accurate identification of protein subGolgi localizations may assist in drug development and understanding the mechanisms of the GA involved in various cellular processes. In this paper, a new computational method is proposed for identifying cis-Golgi proteins from trans-Golgi proteins. Based on the concept of Common Spatial Patterns (CSP), a novel feature extraction technique is developed to extract evolutionary information from protein sequences. To deal with the imbalanced benchmark dataset, the Synthetic Minority Over-sampling Technique (SMOTE) is adopted. A feature selection method called Random Forest-Recursive Feature Elimination (RF-RFE) is employed to search the optimal features from the CSP based features and g-gap dipeptide composition. Based on the optimal features, a Random Forest (RF) module is used to distinguish cis-Golgi proteins from trans-Golgi proteins. Through the jackknife cross-validation, the proposed method achieves a promising performance with a sensitivity of 0.889, a specificity of 0.880, an accuracy of 0.885, and a Matthew’s Correlation Coefficient (MCC) of 0.765, which remarkably outperforms previous methods. Moreover, when tested on a common independent dataset, our method also achieves a significantly improved performance. These results highlight the promising performance of the proposed method to identify Golgi-resident protein types. Furthermore, the CSP based feature extraction method may provide guidelines for protein function predictions.     

复杂电感电路在不同频率特性下本质安全性研究的技术实现

为了探讨不同频率特性下复杂电感电路的本质安全性,利用信号发生器产生不同频率的信号,经功率放大、调压后,作为实验电路的电源,设计出新的实验电路。该电路是研究不同频率特性下复杂电感电路本质安全性的技术基础。     

刍议综采设备对发展高产高效矿井的意义

通过对国内外综采技术发展状况的对比以及对实例的分析,充分论证了综采设备对发展高产高效矿井的意义,并对综采设备的发展提出了一些建议.     

刮板输送机便携式工况测试仪的研究

介绍了便携式刮板输送机工况测试仪的主要研究内容,简要说明了其设计思路、工作原理以及在国家级煤矿掘进机械质量监督检测中心的电机试验台上和便携式刮板输送机工况测试仪进行的对比试验情况。     

纺织品用驱蚊率的测试方法及其装置

阐述了防蚊与驱蚊的差别,介绍了几种常用的实验室驱蚊率测试装置,设计了一种新的适合纺织品用驱蚊率的测试装置,并介绍了测试方法。     

蓄能器在某动力装置流体冲击试验系统中的应用

为验证某动力装置在实际高压流体冲击力作用下能否正常工作,需用一套模拟实际冲击过程的试验装置进行试验研究,其中的蓄能器用于模拟实际冲击源,提供高压流体冲击力。选用压力罐作为蓄能器,通过计算确定蓄能器参数,以达到模拟冲击系统所需要的条件。     

Self-heating activation energy and specific heat capacity of sulphide mixtures at low temperature

Energy of activation (E_a) and specific heat capacity (C_p) for mixtures of sulphide minerals that on their own do not self-heat (SH), sphalerite/pyrite, pyrite/galena, chalcopyrite/galena and sphalerite/galena, were determined using a self-heating apparatus at temperatures below 100 °C in the presence of moisture. The mixtures all gave E_a ranging from 22.0 to 27.8 kJ mol⁻¹, similar to the range reported for Ni- and Cu-concentrates. The E_a is close to that for partial oxidation of H₂S which adds to the contention that the partial oxidation of H₂S contributes to SH of sulphides at low temperature. The C_p values ranged from 0.152 to 1.071 JK⁻¹ g⁻¹ as temperature rose from 50 °C to 80 °C, similar to the reported findings on Ni- and Cu-concentrates. The role of galvanic interaction in promoting SH is tested by examining correlations with the rest potential difference of the sulphides in the mixture.     

35kV、110kV建筑变电所设计的几个问题

简要介绍10～110kV建筑变电所的新设备及新技术,详细介绍10～35kV低电阻接地系统接地电阻的选择、接地故障保护的设置与整定。     

防爆电器产品检测中接地保护与内部导线连接问题的探讨

主要探讨了接地保护和内部连接问题,指出了检测中应注意的问题。     

液力偶合器的应用

文章简述了液力偶合器调速装置的工作原理、结构、特点和应用范围.20t/h抛煤机链条炉鼓、引风机风量调节,由挡板式改造为液力偶合器调节后,节电效果显著.