Design and evaluation of soluble ocular drug insert for controlled release of ciprofloxacin hydrochloride

Purpose: Soluble ocular inserts of ciprofloxacin hydrochloride were prepared with the aim of achieving once a day administration. Design: Drug reservoir was prepared using natural hydrophilic polymer viz. gelatin while rate-controlling membrane was prepared using hydrophobic ethyl cellulose. Ocular inserts were evaluated for their physicochemical parameters like thickness, weight uniformity, drug content, percent moisture loss, and percent moisture absorption. The in vitro drug release studies were carried out using Bi-chambered donar receiver compartment model. Since targeted prolong release was observed in formulation CF2 and CF5, these formulations were further subjected to in vivo drug release study using rabbits as an animal model. In vitro drug release kinetic data was treated according to Zero, First, and Higuchi kinetics to access the mechanism of drug release. Results: Correlation between in vitro and in vivo drug release was found to be strong revealing the efficacy of the formulation. Conclusion: Formulation CF5 has achieved target of present study such as increase residence time, prolong drug release, reduction in frequency of administration, and, thus may improve the patient compliance.     

Heat transfer performance evaluation for turbulent flow through a tube with twisted wire brush inserts

In the present study, the heat transfer performance and friction factor characteristics in a circular tube fitted with twisted wire brush inserts were investigated experimentally. The twisted wire brush inserts were fabricated with four different twisted wire densities of 100, 150, 200, and 250 wires per centimeter by winding a 1 mm diameter of the copper wire over a 5 mm diameter of two twisted iron core-rods. Heat transfer and friction factor data in tubes were examined for Reynolds number ranging from 7,200 to 50,200. The results indicated that the presence of twisted wire brush inserts led to a large effect on the enhancement of heat transfer with corresponding increase in friction factor over the plain tube. The Nusselt number and friction factor of using the twisted wire brush inserts were found to be increased up to 2.15 and 2.0 times, respectively, than those over the plain tube values. Furthermore, the heat transfer performance was evaluated to assess the real benefits of using those type of inserts and the performance was achieved 1.85 times higher compared to the plain tube based on the constant blower power. Finally, correlations were developed based on the data generated from this work to predict the heat transfer, friction factor, and thermal performance factor for turbulent flow through a circular tube fitted with the twisted wire brush inserts in terms of wire density (y), Reynolds number (Re), and Prandtl number (Pr).     

饰品耳坠金属架多工位级进模设计

针对饰品耳坠金属架尺寸小、折弯部分相对主体部分所占比例过大等问题,制定了合理的零件排样方案,设计了一副多工位级进模,将模具中的压型凹模镶块设计成浮动形式,解决了零件弯曲角度超过90°后脱料困难的问题。实践证明,模具结构合理,成形件质量良好,生产效率较高,对同类零件的模具设计有一定参考价值。     

聚合物微流控芯片模具制造关键技术研究进展

成型微通道型腔镶块的加工是聚合物微流控芯片模具制造的核心问题。介绍了国内外微流控芯片模具镶块加工技术的发展状况,分析了各种加工技术的适用范围与发展前景。研究表明,微流控芯片模具镶块制造技术对精密注射成型技术的发展具有一定的推动作用。     

塑料上盖注射模设计

针对塑料上盖带有倒扣、侧凹坑、斜孔和表面质量要求高等特点,合理地选择了分型面和浇口形式,设计了镶拼式成型零件、弹簧侧抽芯机构以及斜推杆和推杆联合推出机构,解决了塑件脱模困难等问题,满足了塑件质量要求。     

加Ti箔中间层的钼-钼扩散焊接

在1 000℃、10 MPa、60 min的工艺条件下,添加5μm的Ti箔作为中间层材料,进行钼-钼基体之间的真空扩散焊接。利用扫描电镜(SEM)观察接头界面形貌,并利用其自带的X射线能谱仪对界面元素扩散情况和中间层区域的元素成分进行测试和分析。结果表明,添加Ti箔作中间层实现钼-钼真空扩散焊接时,Ti原子和Mo原子能够实现良好的扩散,界面区域均为Mo-Ti固溶体,界面焊合率100%。     

从反井钻机多刃镶齿盘形滚刀的发展谈标准的修订

介绍了反井钻机多刃镶齿盘形滚刀的技术发展概况,通过对滚刀主要破坏形式的分析、滚刀适用范围变化、以及技术的发展,阐述标准修订的相关内容。     

液压支架立柱缸体不锈钢镶套修复

为解决缸体修复利用,研究制定出不锈钢滚压复合镶套工艺技术方法。计算分析了镶套修复液压支架立柱缸体的可行性与可靠性;得出镶套修复缸体的最小壁厚、缸孔最大极限尺寸、安全系数、不锈钢套最大厚度等关键技术参数及计算分析方法。制定工艺路线,试制出样机,进行了试验室试验。实现不锈钢与合金结构钢性能的复合优化。批量投入综采面生产应用表明:工作性能稳定,使用寿命提高近2倍,经济技术效益显著。同时,为拓展不锈钢滚压复合镶套工艺技术方法的应用空间,打下了可靠的技术理论基础。     

内插松弛扭带波节管的流动与传热特性的数值模拟

采用RNG k-ε数值模拟方法研究一种新型内插松弛扭带波节管（CLT）的流动与传热特性。将数值模拟结果与自建实验台的实验结果进行了对比验证;比较了CLT和内插松弛扭带光管（SLT）的传热性能差异;考察了CLT中扭率和余隙比对流动和传热特性的影响规律。研究结果表明CLT相比于传统的SLT,传热性能最多提高1.17倍,综合传热性能的绝对数值最多增加0.15。CLT的综合传热性能随着扭率的增加而增加,而增加的幅度却逐渐减小,高Reynolds数时减小的程度更加显著。同时,综合传热性能随着余隙比的增大而降低并且降低的幅度也逐渐减小,在低Reynolds数时明显降低,而在高Reynolds数时略微降低。综合考虑,低Reynolds数时应该选择余隙比低的扭带,而高Reynolds数时则应选择余隙比高的扭带。     

覆盖件修边镶块随形曲面的优化处理方法

为了解决符形类修边镶块刃口面、空刀面等随形曲面创建效率低的问题,提出了一种局部型面裁剪法,仅使用镶块所在位置处的局部型面去裁剪镶块实体,避免对整个型面进行数据搜索处理,解决了完整型面裁剪法耗时过长的问题,使单个镶块的设计效率提高约100%。同时,为了改善非符形类修边镶块随形曲面质量,提出了一种分段式扫略作面法,采用标记法识别曲线的曲率剧变区域,据此将曲线分为多段,进行对应扫略作面再缝合,可解决整体式扫略作面法产生的曲面局部扭曲问题。并通过实例进行效率和质量的对比分析,说明了两种方法的有效性。