Rheological and drug‐release behaviour of a scleroglucan gel matrix at different drug loadings

The aim of this study was to investigate the drug‐loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2 % w/w scleroglucan gel matrix loaded with 0, 0.02, 0.04, 0.06, 0.2 and 0.4 % w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled‐stress rotational‐shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi‐empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04–0.06 % w/w Th range a plasticizing effect and in the 0.2–0.4 % w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug‐release kinetics. Copyright © 2005 Society of Chemical Industry     

交联透明质酸的降解及其释药性能

用己二酸二酰肼（ADH）对透明质酸（HA）进行化学修饰，制备交联透明质酸（HA-ADH）薄膜。粘度法测试表明HA-ADH是一种可降解的生物材料，并且与HA相比，HA．ADH的降解速率减慢。在此基础上，研究了以疏水性的替硝唑（TDZ）和亲水性的头孢唑啉钠（CEZ）为模拟药物的HA-ADH药物载体薄膜的释药性能。紫外-可见（UV-Vis）吸收光谱检测表明，HA-ADH是一种疏水性药物TDZ的优良缓释制荆，这是由于TDZ的疏水性和HA-ADH薄膜的缓慢溶胀和降解性能的结合而得到的，药物的释放主要受扩散机制控制。     

螺栓角钢钢节点的三维非线性有限元分析

对螺栓角钢钢节点半刚性连接采用非线性有限元分析方法 ,对连接中的主要构件的顶部、底部、腹板角钢、高强螺栓、梁翼缘、柱翼缘和柱翼缘加劲肋进行三维非线性有限元精细模拟 ,针对有无柱加劲肋、有无腹板角钢等几种连接的情况进行比较分析 ,探讨了螺栓角钢半刚性连接的受力性能。     

NdFeB永磁靶材溅射模拟

运用SRIM2006软件对Nd2Fe14B靶溅射过程进行了模拟,并就入射离子的入射能量和角度进行了分析,得到溅射产额与入射离子能量、入射角度以及溅射靶材的一般规律:1)溅射产额随着入射离子能量的增加而增加,在低能量区域增加很快,到了高能量区域增加变缓;2)溅射产额随着入射离子入射角度的增大逐渐增大,且在70°~80°出现极大值,如当入射离子的入射角度为75°,入射离子能量为7 keV时,溅射产额可达4.398(原子.离子–1);3)溅射原子的摩尔比与靶材原子摩尔比存在一定偏差,导致薄膜成分与靶材成分不一致。     

绒类织物增光增艳整理

选用多功能复合型绒类织物增光增艳整理剂FSR－2，对纯棉条绒织物进行光泽整理，讨论了光泽剂、交联剂及工艺条件对整理效果的影响，得出了最佳的增光增艳整理工艺。     

Synthesis of TiO<Subscript>2</Subscript> Hybrid Molecular Imprinted Polymer for Ethofumesate Linked by Silane Coupling Agent

TiO₂ hybrid molecular imprinted polymer (MIP) for ethofumesate using methacrylic acid (MAA) as the functional monomer and silane coupling agent 3-(trimethoxysilyl) propylmethacrylate (KH570) as organic–inorganic connective bridge was synthesized via photo-excitation method. Hydrogen bond was proved to act between MAA and ethofumesate for pre- and post-polymerization binding properties as testified by UV spectrometric method. KH570 modified TiO₂ nanoparticles were prepared via sonochemical reaction, which can accelerate hydrolysis, increase collision chance for the reactive system and improve the dispersion of the nanoparticles. Scanning electron microscope (SEM), transmission electron microscope (TEM), binding and the adsorption kinetics experiments as well as thermogravimetric analysis (TGA) were employed for characterization. The results indicated that the hybrid MIP revealed a larger surface area and more ordered imprinting cavities with improved thermal stability compared to organic-only MIP. Furthermore, faster adsorption kinetics and enhancive adsorption capacity were achieved, which made it promising in chemical sensor applications.     

陶瓷减水剂、助磨剂、增强剂的发展现状、趋势及展望

阐述了陶瓷行业所用添加剂的分类，以及目前国际上主要生产陶瓷添加剂的厂家及主要产品，详细介绍了陶瓷坯体减水剂、助磨剂、增强剂的种类、应用、性能特点和它们与陶瓷材料的作用机理，并对陶瓷添加剂的发展前景进行了展望。     

有机羧酸钠盐对PET结晶和熔融行为的影响

采用差示扫描量热仪研究了5种具有不同取代基的苯甲酸钠盐作为结晶成核剂对聚对苯二甲酸乙二醇酯（HET）结晶和熔融行为的影响，并同滑石粉进行了对比。结果表明，成核剂的加入能明显改变PET的结晶和熔融行为。苯甲酸钠、对苯二甲酸甲酯单羧酸钠和对羟基苯甲酸钠提高既汀的熔融结晶温度（Tc）分别达22．93、21．7和19．37℃，但使PET降解严重；对苯酚钠甲酸钠能够提高Tc达17．75℃且对PET相对分子质量影响很小；对苯二甲酸二钠成核作用最差。低于滑石粉。此外，成核剂的成核能力越强，PET双熔融峰中的低温峰顶温度就越高。     

阴离子表面活性剂测定方法的探讨

本文对“阴离子表面活性剂的测定方法”进行探讨,优化了显色剂、萃取剂的用量及萃取频率等分析条件,有效地降低了方法的检出浓度,提高了分析精度及准确度,节约大量试剂。本法最低检出浓度的0.019mL/L。     

Investigation of Centreline Segregation and Centreline Porosity in CC ‐ Slabs

Improvements of solidification processing in conventional or near net shape casting depend on sophisticated methods of macroscopic examination of central unsoundness and inhomogeneity of the cast material. As long as remarkable deviations referring to the quality features exist between the slab centre and the bulk material such methods should be looked after. Two semi‐macroscopic methods of segregation analysis are discussed in this paper: firstly, the potential of the emission spectral analysis combined with sectioning of a sample and secondly, the computer aided micro‐probe analysis. Both methods are restricted to small local areas. The proneness of elements and steel grades with respect to micro‐ and macrosegregation as well as distribution‐ and segregation coefficients are determined. The effect of a diffusion anneal on homogenisation of segregation is studied. Last not least the precipitation of sulphides, phosphides or carbonitrides is estimated. Ultrasonic detection of the central unsoundness of conventional slabs or thin slabs is a new approach towards a quantitative macroscopic examination. The sample size is 400 mm x 300 mm x 30 mm. To achieve a low ultrasonic noise using a 5 MHz‐transducer the samples are heat treated for grain refinement. “Dog bone porosity”, macroscopic topographical misfit between the upper and lower solidifying shells, periodical corner cracks or systematic transverse centre cracks are detected. Obviously, segregations do not reflect the ultrasonic beam. However, it can be presumed that an interrelation exists between porosity and segregation, although these might be locally apart from each other. This new ultrasonic test of the central unsoundness of continuous cast (c.c.) slabs gives valuable arguments to machine builders and maintenance people to decide on the right concepts for strand guidance, support rollers and secondary cooling. Soft reduction can be optimized and variations in casting speed counteracted by dynamic means. R&D service of this kind can help steelmakers when decisions are impending to build new casting machines or revamp old ones.