自身免疫性感音神经性聋的内耳代谢与电生理研究

为探讨自身免疫性感音神经性聋（ＡＳＨＬ）的内耳病理生理学机制，采用听觉电生理技术和酶组织化学方法，观察ＡＳＨＬ模型动物的内耳生理功能与组织内主要酶活性的变化。结果示：听视经复合动作电位和耳蜗微音器电位阈值明显升高，内淋巴电位（包括负相）幅值均有不同程度的降低，并与血管纹和内淋巴囊局部组织内Ｎａ＾＋－Ｋ＾＋－ＡＴＰ酶和琥珀酸脱氢酶活性改变之间的相关性。表明自身免疫性内耳损伤，进而造成组织内相关酶代谢     

喉部癌肉瘤的临床特征

喉部癌肉瘤为一种罕见的病变。为探讨其临床特征，报告诊治１例的临床资料，并结合文献复习，就该病的病理特点、临床表现、治疗及预后进行讨论。     

孕妇下生殖道解脲脲原体感染与妊娠结局关系的探讨

应用聚合酶链反应技术，对２１６例妊娠１２－３７周孕妇的宫颈阴道分泌物和其中１０９例有孕妇分娩时的羊水进行解脲脲原体ＤＮＡ检测，同时临床观察２１６例孕妇的妊娠结局。结果：宫颈阴道分泌物ＵＵ ＤＮＡ阳性率为４３．０６％，宫颈阴道ＵＵ ＤＮＡ阳性组对应的羊水ＵＵ检出率明显高于阴性组，两组平均孕周，平均出生体重，平均Ａｐｇａｒ评分以及胎儿窘迫，早产，剖宫产，低出生体重儿，低Ａｐｇａｒ评分和瘭生儿畸形的发五     

反相高效液相色谱法测定肠炎宁片中槲皮素的含量

用反相高效液相色谱法对肠炎宁片槲皮素的含量进行测定，建立了肠炎宁片中槲皮素含量测定的条件。固定相柱为Ｓｈｉｍ－ＰａｃｋＣＬＣ－ＯＤＳ４．６ｍｍ×１５０ｍｍ；流动相为甲醇－水－磷酸（５５:４４.６:0４）；检测波长２５４ｎｍ。方法平均回收率及ＲＳＤ分别为９９．６％和１．０１％。     

电针加颈动脉注药治疗脑梗塞临床疗效观察

选脑梗塞患者１６０例，随机分为两组。观察组采用电针加颈动脉注药治疗，对照组单用颈动脉注药治疗。结果表明，两组治疗脑梗塞均有肯定疗效，而电针加颈动脉注药疗效明显优于单纯颈动脉注药。     

黄芪毛状根对造血系统功能的作用

本实验研究了黄芪毛状根对动物造血系统的作用,采用灌服给予黄芪毛状根5～20 g/kg,每日1次,连续5～12天,可提高失血性贫血小鼠的红细胞数、网织红细胞数,增加溶血性贫血小鼠的红细胞数、血红蛋白值、红细胞压积值,可对抗环磷酰胺、X射线所致小鼠的白细胞数和骨髓有核细胞数的下降。实验提示黄芪毛状根有促进造血系统功能的作用,其作用基本上与天然黄芪相似。     

嗓音频谱分析中／a／,／i／音采样的比较

应用486微型计算机和北京邮电大学通用信号谱分析系统分别对30例青年女性喉病患者和36例健康对照组的/a/、/i/音嗓音信号进行频谱分析,比较其相对信噪比,结论是在频谱分析中用/a/音采样较/i/音更易检出病态嗓音.     

妊高征孕妇血浆硒水平与红细胞内谷胱甘肽过氧化物酶的关系

目的 探讨妊高征孕妇血浆中硒浓度与红细胞内谷胱甘肽过氧化物酶的关系.方法 应用原子吸收法及细胞化学发光检测法测定49例妊高征孕妇(妊高征组)和34例正常孕妇(正常妊娠组)血浆中硒的水平及红细胞内谷胱甘肽过氧化物酶(GSH-PX)的浓度.结果 妊高征组血浆硒水平及红细胞内GSH-PX浓度明显低于正常妊娠组,而且孕妇血浆中硒水平与红细胞内GSH-PX浓度之间呈直线回归关系,即随着血浆硒水平的升高,红细胞内GSH-PX也升高.结论 孕妇血浆硒水平与红细胞内GSH-PX浓度与妊高征的发病有一定的关系.     

Toxic cardiogenic shock in a patient receiving weekly 24-h infusion of high-dose 5-fluorouracil and leucovorin

A 54-year-old man was treated with weekly 24-h infusion of high-dose 5-fluorouracil (2600 mg/m2) and leucovorin (100 mg/m2) for metastatic colon cancer. At first, he tolerated the treatment well and no significant toxicity was identified. After a total of eight courses of treatment, a stable disease was observed, but mild shortness of breath was found on occasion. The patient had no previous history of cardiac disease and the heart performance assessed by left ventricular ejection fraction before treatment was normal. Unfortunately, acute pulmonary edema with lethal cardiogenic shock occurred during the ninth course of treatment, in spite of intensive medical treatment. The chest X-ray showed extreme cardiomegaly. Repeated assessment of his heart function by echocardiogram and ventricular ejection fraction revealed a very poor cardiac performance. Toxic cardiogenic shock during weekly 24-h infusion of high-dose 5-fluorouracil and leucovorin is extremely rare. To the best of our knowledge, no case has been reported in the English literature. We report a case and the relevant literature about the incidence, clinical picture and possible pathophysiology on 5-fluorouracil-related cardioxicity is reviewed.