肝内胆管结石并发肝内胆管癌的研究进展

肝内胆管结石合并肝内胆管癌,由于难于早期发现,根治性切除机会较少,预后不佳.本文结合国内外文献,就肝内胆管结石合并肝内胆管癌基础及临床研究进展作一综述.     

腹腔镜肾囊肿去顶减压术1例

腹腔镜肾囊肿去顶减压术１例张斌１张炳远１董胜国２病人，女，５５岁。因间断性腹痛５年入院。查体：中年女性，发育正常，营养良好，腹部平坦，全腹未触及肿块，双侧肾脏触诊未见明显异常，双肾区无叩痛。Ｂ超检查诊断为：左肾下极囊肿，大小约５．１ｃｍ×４．４ｃｍ．...     

经腹膜外与经腹腔切除原发性腹膜后肿瘤的对比研究

目的　总结经腹膜外和经腹腔切除原发性腹膜后肿瘤的优缺点 ,探讨最佳手术途径。方法回顾性分析原发性腹膜后肿瘤切除术 4 6例 ,其中经腹腔途径 (transabdominalapproach ,TAA)手术 2 6例 ,为TAA组 ,经腹膜外途径 (extraperitonealapproach ,EPA)手术 2 0例 ,为EPA组。 结果术后并发症发生率EPA组 (2 / 2 0 )比TAA组 (11/ 2 6 )低 (P <0 0 5 ) ,EPA组输血量 4 0 0 (QR∶70 0 )ml少于TAA组 80 0 (QR∶180 0 )ml(u =2 136 85 ,P <0 0 5 ) ,手术时间EPA组 (2 0 5± 6 0 )min短于TAA组(2 5 9± 110 )min(t=2 12 74 ,P <0 0 5 ) ,术后住院天数EPA组 (13± 4 )d少于TAA组 (18± 8)d(t =2 95 33,P <0 0 1) ,差异均有显著意义。结论EPA是原发性腹膜后肿瘤简便安全的手术途径。     

三镜联合分期手术与腹腔镜手术治疗老年胆总管结石合并胆囊结石患者疗效对比研究*

目的 探讨采用三镜联合分期手术与全腹腔镜同期手术治疗老年结石性胆道梗阻并发不同程度急性胆管炎患者的效果。方法 回顾性分析青岛市第三人民医院收治的老年胆总管结石伴急性胆管炎合并胆囊结石患者75例,其中35例观察组患者在入院后急诊行ERCP术,取出胆总管结石或留置胆管支架引流,择期再次入院行腹腔镜胆囊切除术(LC)或LC联合腹腔镜下胆总管取石术(LCBDE),40例对照组患者入院后急诊行LC联合LCBDE术。结果 观察组两次手术时间显著长于对照组(P＜0.05),但术中出血量显著少于对照组(P<0.05);手术后观察组WBC计数、NEUT百分比、血清CRP和PCT水平均显著低于对照组(P＜0.05);术后,观察组血清脑钠肽(BNP)和CK水平分别为(427.0±327.0)pg/ml和(95.0±30.0)U/L,显著低于对照组【分别为(944.0±648.0)pg/ml和(149.0±67.0)U/L,P<0.05】,而血清肌钙蛋白(TNT)和乳酸脱氢酶(LDH)水平分别为(62.8±54.5)pg/ml和(272.0±48.0)U/L,显著高于对照组【分别为(30.5±17.1)pg/ml和(229.0±32.0)U/L,P＜0.05】。结论 采用三镜联合分期手术治疗老年重症急性胆管炎患者,特别是合并有心肌损伤或心功能下降患者能顺利康复,不影响心功能。     

三种二孔法腹腔镜胆囊切除术的临床应用

我们于2005年5月至2007年12月对48例患者实行不同方法的二孔法腹腔镜胆囊切除术,效果满意,现报告如下.     

Transwell侵袭实验测定M受体对胆管癌细胞侵袭的影响

Objective To explore the experiment condition and method for the application of in vitro in vasive Transwell chamber and to observe muscarinicreceptor stimulant and muscarinicreceptor antagonist's influence to cholangiocarcinoma's invasiveness.Methods Two hundred microliter cell suspension of various concentrations(0.5×105/mL,1.0×105/mL,1.5×105/mL and 2.0×105/mL)was added into the upper chamber of the Transwell chamber,and the cells were allowed to penetrate the matrigel for 12,18,24and 48 hours respectively.The numbers was gotten as the invasive cells on the under surface of the membrane.After optimal cell concentration and time were gotten,pilocarpine of various concentrations(0 mmol/L,0.1 mmol/L,0.3 mmol/L and 0.5 mmoL/L)was added into the upper chamber of the Transwell chamber,then the cells on the matrigel were stained and counted.So did the cells when atropine of various concentrations(0.01 mmol/L,0.01 mmol/L,0.05 mmoVL and 0.1 mmol/L)were added into the upper chamher of the Transwell chamber in according to pilocarpine of various concentrations(0 mmol/L,0.3 mmol/L,0.3 mmol/L and 0.3mmol/L).Results With the increase of the time and cell concentrations，the cells couts that penetrated the matrigel increased，while the increase tended to he stable when the culture time exceeded 36 hous and the cell concentration Was over 1.0×105/mL.By adding pilocarpine,there were significant differences between the control and experimental groups(P＜0.05)，but there were no significant differences in experimental groups with various concentrations.There were no significant differences in blank group and experimental groups with atropine added(P＞0.05).When added pilocarpine and atropine,there were significant differences between blank and experimental groups(P＜0.05)，but there were no significant differences in experimental groups with various concentrations.Conclusions Thirty-six hours as invasive time,and one cell concentration 1.0 × 105/mL were optimal to test invasion abilities of cholangiocarcingma cells to different medicines or reagents.There is the possibility that museariniereceptor exists in cholangiocarcinoma cells，and may play an important role in cholangiocarcinoma's invasiveness and metastasis.     

肝门部胆管癌合并重度黄疸者行肝叶切除后并发症的诊治

肝门部胆管癌由于其独特的解剖位置和生物学行为,在根治性手术中50%～100%需要联合肝叶切除[1].对合并重度黄疸的病人(血清总胆红素>171 μmol/L)行联合肝叶切除,其术后并发症诊治情况目前国内未见单独报道.     

腔镜胆囊切除术后钛夹胆总管内游走一例

自1987年法国的Moure首次在人体用腹腔镜方法切除胆囊成功后,腹腔镜逐渐成为胆囊切除的标准术式,腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)后发生钛夹游走是罕见的并发症,Onghena等在1992年首先报道.现将我们治疗的一例报告如下.     

腹腔镜技术对不明原因腹水的诊断价值

①目的 探讨诊断性腹腔镜技术对不明原因腹水的诊断价值。②方法 对56例经多种影像学检查难以明确病因的腹水病人行诊断性腹腔镜检查。③结果 腹腔镜检查病人无手术并发症，52例病人得到明确诊断，诊断明确率达92．8％。④结论 诊断性腹腔镜技术可作为不明原因腹水病人安全准确的诊断方法。